8DJ0
Crystal structure of NavAb L123T as a basis for the human Nav1.7 Inherited Erythromelalgia I848T mutation
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Ion transport protein | polymer | 257 | 29777.2 | 1 | UniProt (A8EVM5) Pfam (PF00520) Pfam (PF08016) In PDB | Aliarcobacter butzleri RM4018 | |
2 | A | 1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE | non-polymer | 678.9 | 5 | Chemie (PX4) | |||
3 | A | 3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE | non-polymer | 614.9 | 2 | Chemie (CPS) | |||
4 | water | water | 18.0 | 7 | Chemie (HOH) |
Sequence modifications
A: 1001 - 1239 (UniProt: A8EVM5)
PDB | External Database | Details |
---|---|---|
Met 983 | - | initiating methionine |
Asp 984 | - | expression tag |
Tyr 985 | - | expression tag |
Lys 986 | - | expression tag |
Asp 987 | - | expression tag |
Asp 988 | - | expression tag |
Asp 989 | - | expression tag |
Asp 990 | - | expression tag |
Lys 991 | - | expression tag |
Gly 992 | - | expression tag |
Ser 993 | - | expression tag |
Leu 994 | - | expression tag |
Val 995 | - | expression tag |
Pro 996 | - | expression tag |
Arg 997 | - | expression tag |
Gly 998 | - | expression tag |
Ser 999 | - | expression tag |
His 1000 | - | expression tag |
Thr 1123 | Leu 123 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 29777.2 | |
Non-Polymers* | Number of molecules | 7 |
Total formula weight | 4624.5 | |
All* | Total formula weight | 34401.7 |