8DJ0

Crystal structure of NavAb L123T as a basis for the human Nav1.7 Inherited Erythromelalgia I848T mutation

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A (A)	Ion transport protein	polymer	257	29777.2	1	UniProt (A8EVM5) Pfam (PF00520)	Aliarcobacter butzleri RM4018
2	B, C, D, E, F (A)	1,2-DIMYRISTOYL-SN-GLYCERO-3-PHOSPHOCHOLINE	non-polymer		678.9	5	Chemie (PX4) PubChem (26198) PubChem (87505) PubChem (5313082)
3	G, H (A)	3-[(3-CHOLAMIDOPROPYL)DIMETHYLAMMONIO]-1-PROPANESULFONATE	non-polymer		614.9	2	Chemie (CPS) PubChem (16396400) PubChem (18397788) PubChem (50987450) PubChem (51028881) PubChem (51028882) PubChem (177530666) PubChem (24883538) PubChem (44120060) PubChem (44450441) PubChem (53393728) PubChem (53229977) PubChem (107670) PubChem (71774074) PubChem (58528211) PubChem (90488808) PubChem (91746229) PubChem (91809267) PubChem (457060) PubChem (102565428) PubChem (122361936) PubChem (122362044) PubChem (3659871) PubChem (131632459) PubChem (133645855) PubChem (9895216) PubChem (10371606) PubChem (137704711) PubChem (146159681)
4	I (A)	water	water		18.0	7	Chemie (HOH)

Sequence modifications

A: 1001 - 1239 (UniProt: A8EVM5)

PDB	External Database	Details
Met 983	-	initiating methionine
Asp 984	-	expression tag
Tyr 985	-	expression tag
Lys 986	-	expression tag
Asp 987	-	expression tag
Asp 988	-	expression tag
Asp 989	-	expression tag
Asp 990	-	expression tag
Lys 991	-	expression tag
Gly 992	-	expression tag
Ser 993	-	expression tag
Leu 994	-	expression tag
Val 995	-	expression tag
Pro 996	-	expression tag
Arg 997	-	expression tag
Gly 998	-	expression tag
Ser 999	-	expression tag
His 1000	-	expression tag
Thr 1123	Leu 123	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	29777.2
Non-Polymers*	Number of molecules	7
	Total formula weight	4624.5
All*	Total formula weight	34401.7

*Water molecules are not included.