7QN6
| Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with nanobody Nb25 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | Authors: | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | Deposit date: | 2021-12-20 | Release date: | 2022-04-13 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QN7
| Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25 | Descriptor: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | Deposit date: | 2021-12-20 | Release date: | 2022-04-13 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QNE
| Cryo-EM structure of human full-length synaptic alpha1beta3gamma2 GABA(A)R in complex with Ro15-4513 and megabody Mb38 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ... | Authors: | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | Deposit date: | 2021-12-20 | Release date: | 2022-04-13 | Last modified: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QN8
| Cryo-EM structure of human full-length beta3delta GABA(A)R in complex with histamine and nanobody Nb25 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Gamma-aminobutyric acid receptor subunit beta-3, ... | Authors: | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | Deposit date: | 2021-12-20 | Release date: | 2022-04-13 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QN5
| Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with nanobody Nb25 | Descriptor: | 1,2-DIPALMITOYL-SN-GLYCERO-3-PHOSPHATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | Deposit date: | 2021-12-20 | Release date: | 2022-04-13 | Last modified: | 2022-05-04 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QNB
| Cryo-EM structure of human full-length beta3gamma2 GABA(A)R in complex with GABA and nanobody Nb25 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GAMMA-AMINO-BUTANOIC ACID, ... | Authors: | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | Deposit date: | 2021-12-20 | Release date: | 2022-04-13 | Last modified: | 2023-11-15 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QNC
| Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one, ... | Authors: | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | Deposit date: | 2021-12-20 | Release date: | 2022-04-13 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QND
| Cryo-EM structure of human full-length extrasynaptic beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 4,5,6,7-tetrahydro-[1,2]oxazolo[5,4-c]pyridin-3-one, ... | Authors: | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | Deposit date: | 2021-12-20 | Release date: | 2022-04-13 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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7QN9
| Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with GABA, histamine and nanobody Nb25 in a pre-open/closed state | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, DECANE, ... | Authors: | Sente, A, Desai, R, Naydenova, K, Malinauskas, T, Jounaidi, Y, Miehling, J, Zhou, X, Masiulis, S, Hardwick, S.W, Chirgadze, D.Y, Miller, K.W, Aricescu, A.R. | Deposit date: | 2021-12-20 | Release date: | 2022-04-13 | Last modified: | 2022-04-20 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604, 2022
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5AOH
| Crystal Structure of CarF | Descriptor: | POTASSIUM ION, Spore coat protein CotH | Authors: | Tichy, E.M, Hardwick, S.W, Luisi, B.F, C Salmond, G.P. | Deposit date: | 2015-09-10 | Release date: | 2017-01-25 | Last modified: | 2019-09-25 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | 1.8 angstrom resolution crystal structure of the carbapenem intrinsic resistance protein CarF. Acta Crystallogr D Struct Biol, 73, 2017
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5FT0
| Crystal structure of gp37(Dip) from bacteriophage phiKZ | Descriptor: | ARGININE, GP37, POTASSIUM ION | Authors: | Van den Bossche, A, Hardwick, S.W, Ceyssens, P.J, Hendrix, H, Voet, M, Dendooven, T, Bandyra, K.J, De Maeyer, M, Aertsen, A, Noben, J.P, Luisi, B.F, Lavigne, R. | Deposit date: | 2016-01-08 | Release date: | 2016-08-03 | Last modified: | 2017-03-22 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome. Elife, 5, 2016
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5FT1
| Crystal structure of gp37(Dip) from bacteriophage phiKZ bound to RNase E of Pseudomonas aeruginosa | Descriptor: | GP37, RIBONUCLEASE E | Authors: | Van den Bossche, A, Hardwick, S.W, Ceyssens, P.J, Hendrix, H, Voet, M, Dendooven, T, Bandyra, K.J, De Maeyer, M, Aertsen, A, Noben, J.P, Luisi, B.F, Lavigne, R. | Deposit date: | 2016-01-08 | Release date: | 2016-08-03 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.75 Å) | Cite: | Structural elucidation of a novel mechanism for the bacteriophage-based inhibition of the RNA degradosome. Elife, 5, 2016
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8B0J
| CryoEM structure of bacterial RNaseE.RapZ.GlmZ complex central to the control of cell envelope biogenesis | Descriptor: | GlmZ small RNA, RNase adapter protein RapZ, Ribonuclease E | Authors: | Islam, M.S, Hardwick, H.W, Chirgadze, D.Y, Luisi, B.F. | Deposit date: | 2022-09-07 | Release date: | 2022-10-05 | Last modified: | 2023-01-25 | Method: | ELECTRON MICROSCOPY (3.99 Å) | Cite: | Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis. Embo J., 42, 2023
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8B0I
| CryoEM structure of bacterial RapZ.GlmZ complex central to the control of cell envelope biogenesis | Descriptor: | GlmZ small regulatory RNA, RNase adapter protein RapZ | Authors: | Islam, M.S, Hardwick, H.W, Chirgadze, D.Y, Luisi, B.F. | Deposit date: | 2022-09-07 | Release date: | 2022-10-05 | Last modified: | 2023-01-25 | Method: | ELECTRON MICROSCOPY (4.28 Å) | Cite: | Structure of a bacterial ribonucleoprotein complex central to the control of cell envelope biogenesis. Embo J., 42, 2023
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5NBB
| Structure of the C-terminal domain of the Escherichia Coli ProQ RNA binding protein | Descriptor: | RNA chaperone ProQ | Authors: | Gonzales, G, Hardwick, S, Maslen, S, Skehel, M, Holmqvist, E, Vogel, J, Bateman, A, Luisi, B, Broadhurst, R. | Deposit date: | 2017-03-01 | Release date: | 2017-05-03 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structure of the Escherichia coli ProQ RNA-binding protein. RNA, 23, 2017
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5NB9
| Structure of the N-terminal domain of the Escherichia Coli ProQ RNA binding protein | Descriptor: | RNA chaperone ProQ | Authors: | Gonzales, G, Hardwick, S, Maslen, S, Skehel, M, Holmqvist, E, Vogel, J, Bateman, A, Luisi, B, Broadhurst, R. | Deposit date: | 2017-03-01 | Release date: | 2017-05-03 | Last modified: | 2023-06-14 | Method: | SOLUTION NMR | Cite: | Structure of the Escherichia coli ProQ RNA-binding protein. RNA, 23, 2017
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1W53
| Kinase recruitment domain of the stress phosphatase RsbU | Descriptor: | GLYCEROL, PHOSPHOSERINE PHOSPHATASE RSBU, XENON | Authors: | Delumeau, O, Dutta, S, Brigulla, M, Kuhnke, G, Hardwick, S.W, Voelker, U, Yudkin, M.D, Lewis, R.J. | Deposit date: | 2004-08-05 | Release date: | 2004-08-05 | Last modified: | 2015-03-25 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Functional and Structural Characterization of Rsbu, a Stress Signaling Protein Phosphatase 2C J.Biol.Chem., 279, 2004
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7Z6O
| X-Ray studies of Ku70/80 reveal the binding site for IP6 | Descriptor: | DNA (5'-D(*GP*TP*TP*TP*TP*TP*AP*GP*TP*TP*TP*AP*T)-3'), DNA (5'-D(P*AP*AP*AP*TP*AP*AP*AP*CP*TP*AP*AP*AP*AP*AP*C)-3'), INOSITOL HEXAKISPHOSPHATE, ... | Authors: | Varela, P.F, Charbonnier, J.B. | Deposit date: | 2022-03-14 | Release date: | 2023-08-30 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (3.7 Å) | Cite: | Structural and functional basis of inositol hexaphosphate stimulation of NHEJ through stabilization of Ku-XLF interaction. Nucleic Acids Res., 51, 2023
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7ZT6
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7AG8
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7OPL
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7OTM
| Cryo-EM structure of DNA-PKcs in complex with NU7441 | Descriptor: | 8-(dibenzo[b,d]thiophen-4-yl)-2-(morpholin-4-yl)-4H-chromen-4-one, DNA-dependent protein kinase catalytic subunit,DNA-PKcs | Authors: | Liang, S, Thomas, S.E, Blundell, T.L. | Deposit date: | 2021-06-10 | Release date: | 2022-01-12 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (3.33 Å) | Cite: | Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs. Nature, 601, 2022
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7OTP
| DNA-PKcs in complex with ATPgammaS-Mg | Descriptor: | DNA-dependent protein kinase catalytic subunit,DNA-PKcs, MAGNESIUM ION, PHOSPHOTHIOPHOSPHORIC ACID-ADENYLATE ESTER | Authors: | Liang, S, Thomas, S.E, Blundell, T.L. | Deposit date: | 2021-06-10 | Release date: | 2022-01-12 | Last modified: | 2022-02-09 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs. Nature, 601, 2022
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6XTX
| CryoEM structure of human CMG bound to ATPgammaS and DNA | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Cell division control protein 45 homolog, DNA (5'-D(P*TP*TP*TP*TP*TP*TP*TP*TP*TP*TP*T)-3'), ... | Authors: | Rzechorzek, N.J, Pellegrini, L. | Deposit date: | 2020-01-16 | Release date: | 2020-05-27 | Last modified: | 2020-07-15 | Method: | ELECTRON MICROSCOPY (3.29 Å) | Cite: | CryoEM structures of human CMG-ATP gamma S-DNA and CMG-AND-1 complexes. Nucleic Acids Res., 48, 2020
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7A2I
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