7QND

Cryo-EM structure of human full-length extrasynaptic beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25

Summary for 7QND

Entry DOI	10.2210/pdb7qnd/pdb
EMDB information	14075
Descriptor	Gamma-aminobutyric acid receptor subunit beta-3, Gamma-aminobutyric acid receptor subunit delta, Nanobody Nb25, ... (8 entities in total)
Functional Keywords	pentameric ligand-gated ion channel, neurotransmitter receptor, gaba receptor, membrane protein
Biological source	Homo sapiens (human) More
Total number of polymer chains	8
Total formula weight	315220.22
Authors	Sente, A.,Desai, R.,Naydenova, K.,Malinauskas, T.,Jounaidi, Y.,Miehling, J.,Zhou, X.,Masiulis, S.,Hardwick, S.W.,Chirgadze, D.Y.,Miller, K.W.,Aricescu, A.R. (deposition date: 2021-12-20, release date: 2022-04-13, Last modification date: 2022-04-20)
Primary citation	Sente, A.,Desai, R.,Naydenova, K.,Malinauskas, T.,Jounaidi, Y.,Miehling, J.,Zhou, X.,Masiulis, S.,Hardwick, S.W.,Chirgadze, D.Y.,Miller, K.W.,Aricescu, A.R. Differential assembly diversifies GABA A receptor structures and signalling. Nature, 604:190-194, 2022 Cited by PubMed: 35355020 DOI: 10.1038/s41586-022-04517-3 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (3.4 Å)

Structure validation