7QNC

Cryo-EM structure of human full-length extrasynaptic alpha4beta3delta GABA(A)R in complex with THIP (gaboxadol), histamine and nanobody Nb25

Summary for 7QNC

• Entry DOI: 10.2210/pdb7qnc/pdb
• EMDB information: 14074
• Descriptor: Gamma-aminobutyric acid receptor subunit alpha-4, HISTAMINE, Gamma-aminobutyric acid receptor subunit beta-3, ... (10 entities in total)
• Functional Keywords: pentameric ligand-gated ion channel, neurotransmitter receptor, gaba receptor, membrane protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 7
• Total formula weight: 310531.66

Authors

Sente, A.,Desai, R.,Naydenova, K.,Malinauskas, T.,Jounaidi, Y.,Miehling, J.,Zhou, X.,Masiulis, S.,Hardwick, S.W.,Chirgadze, D.Y.,Miller, K.W.,Aricescu, A.R. (deposition date: 2021-12-20, release date: 2022-04-13, Last modification date: 2022-04-20)

• Primary citation: Sente, A.,Desai, R.,Naydenova, K.,Malinauskas, T.,Jounaidi, Y.,Miehling, J.,Zhou, X.,Masiulis, S.,Hardwick, S.W.,Chirgadze, D.Y.,Miller, K.W.,Aricescu, A.R.; Differential assembly diversifies GABA A receptor structures and signalling.; Nature, 604:190-194, 2022; PubMed: 35355020; DOI: 10.1038/s41586-022-04517-3

Experimental method

ELECTRON MICROSCOPY (2.9 Å)