7OTM
Cryo-EM structure of DNA-PKcs in complex with NU7441
Summary for 7OTM
Entry DOI | 10.2210/pdb7otm/pdb |
EMDB information | 13062 |
Descriptor | DNA-dependent protein kinase catalytic subunit,DNA-PKcs, 8-(dibenzo[b,d]thiophen-4-yl)-2-(morpholin-4-yl)-4H-chromen-4-one (2 entities in total) |
Functional Keywords | complex, inhibitor, dna repair, dna binding protein |
Biological source | Homo sapiens (Human) More |
Total number of polymer chains | 1 |
Total formula weight | 471788.89 |
Authors | Liang, S.,Thomas, S.E.,Blundell, T.L. (deposition date: 2021-06-10, release date: 2022-01-12, Last modification date: 2022-02-09) |
Primary citation | Liang, S.,Thomas, S.E.,Chaplin, A.K.,Hardwick, S.W.,Chirgadze, D.Y.,Blundell, T.L. Structural insights into inhibitor regulation of the DNA repair protein DNA-PKcs. Nature, 601:643-648, 2022 Cited by PubMed: 34987222DOI: 10.1038/s41586-021-04274-9 PDB entries with the same primary citation |
Experimental method | ELECTRON MICROSCOPY (3.33 Å) |
Structure validation
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