7DNI
 
 | | MDA5 CARDs-MAVS CARD polyUb complex | | Descriptor: | Interferon-induced helicase C domain-containing protein 1, Mitochondrial antiviral-signaling protein, Ubiquitin | | Authors: | Song, B, Chen, Y, Luo, D.H, Zheng, J. | | Deposit date: | 2020-12-09 | | Release date: | 2021-10-13 | | Last modified: | 2022-02-16 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Ordered assembly of the cytosolic RNA-sensing MDA5-MAVS signaling complex via binding to unanchored K63-linked poly-ubiquitin chains.
Immunity, 54, 2021
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8D7Y
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8D7X
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3U9Q
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7ZC9
 | | Human Pikachurin/EGFLAM C-terminal Laminin-G domain (LG3) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Pikachurin, SULFATE ION | | Authors: | Pantalone, S, Forneris, F. | | Deposit date: | 2022-03-26 | | Release date: | 2023-07-19 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179.
Sci.Signal., 16, 2023
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7ZCB
 | | Human Pikachurin/EGFLAM N-terminal Fibronectin-III (1-2) domains | | Descriptor: | CHLORIDE ION, Pikachurin, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Pantalone, S, Savino, S, Viti, L.V, Forneris, F. | | Deposit date: | 2022-03-26 | | Release date: | 2023-07-19 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Structure of the photoreceptor synaptic assembly of the extracellular matrix protein pikachurin with the orphan receptor GPR179.
Sci.Signal., 16, 2023
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7KSL
 | | Substrate-free human mitochondrial LONP1 | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, Lon protease homolog, mitochondrial | | Authors: | Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. | | Deposit date: | 2020-11-23 | | Release date: | 2020-12-09 | | Last modified: | 2022-06-15 | | Method: | ELECTRON MICROSCOPY (3.5 Å) | | Cite: | Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.
Nat Commun, 12, 2021
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7KSM
 | | Human mitochondrial LONP1 with endogenous substrate | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Lon protease homolog, ... | | Authors: | Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. | | Deposit date: | 2020-11-23 | | Release date: | 2020-12-02 | | Last modified: | 2022-06-15 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.
Nat Commun, 12, 2021
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7KRZ
 | | Human mitochondrial LONP1 in complex with Bortezomib | | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Endogenous co-purified substrate, ... | | Authors: | Shin, M, Watson, E.R, Song, A.S, Mindrebo, J.T, Novick, S.R, Griffin, P, Wiseman, R.L, Lander, G.C. | | Deposit date: | 2020-11-20 | | Release date: | 2021-02-24 | | Last modified: | 2022-06-15 | | Method: | ELECTRON MICROSCOPY (3.2 Å) | | Cite: | Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.
Nat Commun, 12, 2021
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5TTO
 | | X-ray crystal structure of PPARgamma in complex with SR1643 | | Descriptor: | 4-bromo-N-{3,5-dichloro-4-[(quinolin-3-yl)oxy]phenyl}-2,5-difluorobenzene-1-sulfonamide, Peroxisome proliferator-activated receptor gamma | | Authors: | Bruning, J.B, Frkic, R.L, Griffin, P, Kamenecka, T, Abell, A. | | Deposit date: | 2016-11-04 | | Release date: | 2017-05-24 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.246 Å) | | Cite: | Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPAR gamma-Targeted Antidiabetics.
J. Med. Chem., 60, 2017
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5X0R
 | | Crystal Structure of PXR LBD Complexed with SJB7 | | Descriptor: | 4-[(4-tert-butylphenyl)sulfonyl]-1-(2,4-dimethoxy-5-methylphenyl)-5-methyl-1H-1,2,3-triazole, Nuclear receptor coactivator 1, Nuclear receptor subfamily 1 group I member 2 | | Authors: | Lv, L, Lin, W, Chai, S.C, Zhang, Q, Chen, T. | | Deposit date: | 2017-01-23 | | Release date: | 2017-10-04 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.665 Å) | | Cite: | SPA70 is a potent antagonist of human pregnane X receptor.
Nat Commun, 8, 2017
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8T2I
 | | Negative stain EM assembly of MYC, JAZ, and NINJA complex | | Descriptor: | AFP homolog 2, Maltose/maltodextrin-binding periplasmic protein, Protein TIFY 10A, ... | | Authors: | Zhou, X.E, Zhang, Y, Zhou, Y, He, Q, Cao, X, Kariapper, L, Suino-Powell, K, Zhu, Y, Zhang, F, Karsten, M. | | Deposit date: | 2023-06-06 | | Release date: | 2023-06-28 | | Last modified: | 2023-11-22 | | Method: | ELECTRON MICROSCOPY (10.4 Å) | | Cite: | Assembly of JAZ-JAZ and JAZ-NINJA complexes in jasmonate signaling.
Plant Commun., 4, 2023
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8T85
 | | Structure of RssB bound to beryllofluoride | | Descriptor: | BERYLLIUM TRIFLUORIDE ION, DI(HYDROXYETHYL)ETHER, MAGNESIUM ION, ... | | Authors: | Brugger, C, Schwartz, J, Deaconescu, A.M. | | Deposit date: | 2023-06-21 | | Release date: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (2.38 Å) | | Cite: | Structure of phosphorylated-like RssB, the adaptor delivering sigma s to the ClpXP proteolytic machinery, reveals an interface switch for activation.
J.Biol.Chem., 299, 2023
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6WMQ
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6WMS
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6N9G
 | | Crystal Structure of RGS7-Gbeta5 dimer | | Descriptor: | Guanine nucleotide-binding protein subunit beta-5, Regulator of G-protein signaling 7 | | Authors: | Patil, D.N, Rangarajan, E, Izard, T, Martemyanov, K.A. | | Deposit date: | 2018-12-03 | | Release date: | 2019-01-09 | | Last modified: | 2023-10-11 | | Method: | X-RAY DIFFRACTION (2.129 Å) | | Cite: | Structural organization of a major neuronal G protein regulator, the RGS7-G beta 5-R7BP complex.
Elife, 7, 2018
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4IS8
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3GZ0
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4XI3
 | | Estrogen Receptor Alpha Ligand Binding Domain in Complex with Bazedoxifene | | Descriptor: | Bazedoxifene, Estrogen receptor | | Authors: | Fanning, S.W, Mayne, C.G, Toy, W, Carlson, K, Greene, B, Nowak, J, Walter, R, Panchamukhi, S, Tajhorshid, E, Nettles, K.W, Chandarlapaty, S, Katzenellenbogen, J, Greene, G.L. | | Deposit date: | 2015-01-06 | | Release date: | 2016-01-13 | | Last modified: | 2024-03-06 | | Method: | X-RAY DIFFRACTION (2.491 Å) | | Cite: | The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells.
Elife, 7, 2018
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4YWC
 | | Crystal structure of Myc3(5-242) fragment in complex with Jaz9(218-239) peptide | | Descriptor: | Protein TIFY 7, Transcription factor MYC3 | | Authors: | Ke, J, Zhang, F, Brunzelle, J.S, Xu, H.E, Melcher, K, He, S.Y. | | Deposit date: | 2015-03-20 | | Release date: | 2015-08-05 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis of JAZ repression of MYC transcription factors in jasmonate signalling.
Nature, 525, 2015
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6DHA
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6DGL
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6E9E
 | | EsCas13d-crRNA binary complex | | Descriptor: | EsCas13d, MAGNESIUM ION, crRNA (52-MER) | | Authors: | Zhang, C, Lyumkis, D. | | Deposit date: | 2018-08-01 | | Release date: | 2018-10-03 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.4 Å) | | Cite: | Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d.
Cell, 175, 2018
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6E9F
 | | EsCas13d-crRNA-target RNA ternary complex | | Descriptor: | EsCas13d, MAGNESIUM ION, RNA (27-MER), ... | | Authors: | Zhang, C, Lyumkis, D. | | Deposit date: | 2018-08-01 | | Release date: | 2018-10-03 | | Last modified: | 2024-03-13 | | Method: | ELECTRON MICROSCOPY (3.3 Å) | | Cite: | Structural Basis for the RNA-Guided Ribonuclease Activity of CRISPR-Cas13d.
Cell, 175, 2018
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6DGR
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