3U9Q

Ligand binding domain of PPARgamma complexed with Decanoic Acid and PGC-1a peptide

Summary for 3U9Q

DescriptorPeroxisome proliferator-activated receptor gamma, PGC-1a peptide, DECANOIC ACID, ... (4 entities in total)
Functional Keywordsnuclear receptor, adipogenesis, rxra, nucleus, transcription
Biological sourceHomo sapiens (human)
Cellular locationNucleus P37231
Isoform 1: Nucleus. Isoform B4: Nucleus. Isoform B4-8a: Cytoplasm. Isoform B5: Nucleus. Isoform 9: Nucleus  Q9UBK2
Total number of polymer chains2
Total molecular weight31877.32
Authors
Malapaka, V.R.,Xu, H.E. (deposition date: 2011-10-19, release date: 2011-11-09, Last modification date: 2017-11-08)
Primary citation
Malapaka, R.R.,Khoo, S.,Zhang, J.,Choi, J.H.,Zhou, X.E.,Xu, Y.,Gong, Y.,Li, J.,Yong, E.L.,Chalmers, M.J.,Chang, L.,Resau, J.H.,Griffin, P.R.,Chen, Y.E.,Xu, H.E.
Identification and Mechanism of 10-Carbon Fatty Acid as Modulating Ligand of Peroxisome Proliferator-activated Receptors.
J.Biol.Chem., 287:183-195, 2012
PubMed: 22039047 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M111.294785
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.522 Å)
NMR Information
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.219100.8%1.3%8.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation report