5TTO

X-ray crystal structure of PPARgamma in complex with SR1643

Summary for 5TTO

Entry DOI	10.2210/pdb5tto/pdb
Descriptor	Peroxisome proliferator-activated receptor gamma, 4-bromo-N-{3,5-dichloro-4-[(quinolin-3-yl)oxy]phenyl}-2,5-difluorobenzene-1-sulfonamide (3 entities in total)
Functional Keywords	nuclear receptor, transcription
Biological source	Homo sapiens (Human)
Cellular location	Nucleus: P37231
Total number of polymer chains	2
Total formula weight	63536.86
Authors	Bruning, J.B.,Frkic, R.L.,Griffin, P.,Kamenecka, T.,Abell, A. (deposition date: 2016-11-04, release date: 2017-05-24, Last modification date: 2023-10-04)
Primary citation	Frkic, R.L.,He, Y.,Rodriguez, B.B.,Chang, M.R.,Kuruvilla, D.,Ciesla, A.,Abell, A.D.,Kamenecka, T.M.,Griffin, P.R.,Bruning, J.B. Structure-Activity Relationship of 2,4-Dichloro-N-(3,5-dichloro-4-(quinolin-3-yloxy)phenyl)benzenesulfonamide (INT131) Analogs for PPAR gamma-Targeted Antidiabetics. J. Med. Chem., 60:4584-4593, 2017 Cited by PubMed: 28485590 DOI: 10.1021/acs.jmedchem.6b01727 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.246 Å)

Structure validation