8D7Y
Cereblon-DDB1 in the Apo form with DDB1 in the twisted conformation
Summary for 8D7Y
| Entry DOI | 10.2210/pdb8d7y/pdb |
| EMDB information | 27012 27234 27235 27236 27237 27238 27239 27240 27241 27242 |
| Descriptor | DNA damage-binding protein 1, Protein cereblon, ZINC ION (3 entities in total) |
| Functional Keywords | ubiquitin, crl4, adaptor, cereblon, ligase |
| Biological source | Homo sapiens (human) More |
| Total number of polymer chains | 2 |
| Total formula weight | 177766.55 |
| Authors | Watson, E.R.,Lander, G.C. (deposition date: 2022-06-07, release date: 2022-07-20, Last modification date: 2022-11-30) |
| Primary citation | Watson, E.R.,Novick, S.,Matyskiela, M.E.,Chamberlain, P.P.,H de la Pena, A.,Zhu, J.,Tran, E.,Griffin, P.R.,Wertz, I.E.,Lander, G.C. Molecular glue CELMoD compounds are regulators of cereblon conformation. Science, 378:549-553, 2022 Cited by PubMed: 36378961DOI: 10.1126/science.add7574 PDB entries with the same primary citation |
| Experimental method | ELECTRON MICROSCOPY (3.4 Å) |
Structure validation
Download full validation report
