7KRZ

Human mitochondrial LONP1 in complex with Bortezomib

Summary for 7KRZ

• Entry DOI: 10.2210/pdb7krz/pdb
• EMDB information: 23013 23019 23020
• Descriptor: Lon protease homolog, mitochondrial, Endogenous co-purified substrate, ADENOSINE-5'-TRIPHOSPHATE, ... (6 entities in total)
• Functional Keywords: aaa+, atpase, protease, mitochondrial, lonp1, lon, hydrolase
• Biological source: Homo sapiens (Human); More
• Total number of polymer chains: 7
• Total formula weight: 362209.14

Authors

Shin, M.,Watson, E.R.,Song, A.S.,Mindrebo, J.T.,Novick, S.R.,Griffin, P.,Wiseman, R.L.,Lander, G.C. (deposition date: 2020-11-20, release date: 2021-02-24, Last modification date: 2022-06-15)

• Primary citation: Shin, M.,Watson, E.R.,Song, A.S.,Mindrebo, J.T.,Novick, S.J.,Griffin, P.R.,Wiseman, R.L.,Lander, G.C.; Structures of the human LONP1 protease reveal regulatory steps involved in protease activation.; Nat Commun, 12:3239-3239, 2021; PubMed: 34050165; DOI: 10.1038/s41467-021-23495-0

Experimental method

ELECTRON MICROSCOPY (3.2 Å)