3VTP
| HIV fusion inhibitor MT-C34 | Descriptor: | Transmembrane protein gp41 | Authors: | Yao, X, Waltersperger, S, Wang, M, Cui, S. | Deposit date: | 2012-06-02 | Release date: | 2012-08-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | The M-T hook structure is critical for design of HIV-1 fusion inhibitors. J.Biol.Chem., 287, 2012
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3VGX
| Structure of gp41 T21/Cp621-652 | Descriptor: | ACETIC ACID, Envelope glycoprotein gp160, GLYCEROL | Authors: | Yao, X, Waltersperger, S, Wang, M, Cui, S. | Deposit date: | 2011-08-22 | Release date: | 2012-04-25 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Discovery of critical residues for viral entry and inhibition through structural Insight of HIV-1 fusion inhibitor CP621-652. J.Biol.Chem., 287, 2012
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3VH7
| Structure of HIV-1 gp41 NHR/fusion inhibitor complex P21 | Descriptor: | CP32M, Envelope glycoprotein gp160, MAGNESIUM ION | Authors: | Yao, X, Waltersperger, S, Wang, M.T, Cui, S. | Deposit date: | 2011-08-23 | Release date: | 2012-06-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.019 Å) | Cite: | Structural basis of potent and broad HIV-1 fusion inhibitor CP32M J.Biol.Chem., 287, 2012
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3VGY
| Structure of HIV-1 gp41 NHR/fusion inhibitor complex P321 | Descriptor: | CP32M, Envelope glycoprotein gp160, SULFATE ION | Authors: | Yao, X, Waltersperger, S, Wang, M.T, Cui, S. | Deposit date: | 2011-08-22 | Release date: | 2012-06-13 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.034 Å) | Cite: | Structural basis of potent and broad HIV-1 fusion inhibitor CP32M J.Biol.Chem., 287, 2012
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3VU5
| Short peptide HIV entry Inhibitor SC22EK | Descriptor: | AMMONIUM ION, SC22, SULFATE ION, ... | Authors: | Yao, X, Chong, H.H, Waltersperger, S, Wang, M.T, He, Y.X, Cui, S. | Deposit date: | 2012-06-19 | Release date: | 2012-12-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.087 Å) | Cite: | Short-peptide fusion inhibitors with high potency against wild-type and enfuvirtide-resistant HIV-1 Faseb J., 27, 2013
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3VWB
| Crystal structure of VirB core domain (Se-Met derivative) complexed with the cis-acting site (5-BRU modifications) upstream icsb promoter | Descriptor: | DNA (26-MER), Virulence regulon transcriptional activator virB | Authors: | Gao, X.P, Waltersperger, S, Wang, M.T, Cui, S. | Deposit date: | 2012-08-21 | Release date: | 2013-08-21 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.416 Å) | Cite: | Structural insights into VirB-DNA complexes reveal mechanism of transcriptional activation of virulence genes Nucleic Acids Res., 41, 2013
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3W19
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3VIE
| HIV-gp41 fusion inhibitor Sifuvirtide | Descriptor: | Envelope glycoprotein gp160, Sifuvirtide | Authors: | Yao, X, Waltersperger, S, Wang, M.T, Cui, S. | Deposit date: | 2011-09-29 | Release date: | 2012-01-18 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide J.Biol.Chem., 287, 2012
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3VTQ
| Novel HIV fusion inhibitor | Descriptor: | Envelope glycoprotein gp160, fusion inhibitor MT-Sifuvirtide | Authors: | Yao, X, Waltersperger, S, Wang, M, Cui, S. | Deposit date: | 2012-06-02 | Release date: | 2013-06-26 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (1.53 Å) | Cite: | Crystal structure of a novel HIV fusion inhibitor To be Published
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3VU6
| Short peptide HIV entry inhibitor MT-SC22EK with a M-T hook | Descriptor: | MTSC22, SULFATE ION, Transmembrane protein gp41 | Authors: | Yao, X, Chong, H.H, Waltersperger, S, Wang, M.T, He, Y.X, Cui, S. | Deposit date: | 2012-06-19 | Release date: | 2012-12-19 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.324 Å) | Cite: | Short-peptide fusion inhibitors with high potency against wild-type and enfuvirtide-resistant HIV-1 Faseb J., 27, 2013
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3W2A
| Crystal structure of VirB core domain complexed with the cis-acting site upstream icsp promoter | Descriptor: | DNA (31-mer), Virulence regulon transcriptional activator VirB | Authors: | Gao, X.P, Waltersperger, S, Wang, M.T, Cui, S. | Deposit date: | 2012-11-27 | Release date: | 2013-09-04 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (2.775 Å) | Cite: | Structural insights into VirB-DNA complexes reveal mechanism of transcriptional activation of virulence genes Nucleic Acids Res., 41, 2013
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3W3C
| Crystal structure of VirB core domain complexed with the cis-acting site upstream icsb promoter | Descriptor: | DNA (26-MER), Virulence regulon transcriptional activator VirB | Authors: | Gao, X.P, Waltersperger, S, Wang, M.T, Cui, S. | Deposit date: | 2012-12-19 | Release date: | 2013-09-04 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.431 Å) | Cite: | Structural insights into VirB-DNA complexes reveal mechanism of transcriptional activation of virulence genes Nucleic Acids Res., 41, 2013
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5WWP
| Crystal structure of Middle East respiratory syndrome coronavirus helicase (MERS-CoV nsp13) | Descriptor: | ORF1ab, SULFATE ION, ZINC ION | Authors: | Hao, W, Wojdyla, J.A, Zhao, R, Han, R, Das, R, Zlatev, I, Manoharan, M, Wang, M, Cui, S. | Deposit date: | 2017-01-03 | Release date: | 2017-07-05 | Last modified: | 2021-09-15 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of Middle East respiratory syndrome coronavirus helicase PLoS Pathog., 13, 2017
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3STQ
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3W95
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3X0F
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3X0E
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3X0G
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3OC3
| Crystal structure of the Mot1 N-terminal domain in complex with TBP | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, HELICASE MOT1, TRANSCRIPTION INITIATION FACTOR TFIID (TFIID-1) | Authors: | Wollmann, P, Cui, S, Viswanathan, R, Berninghausen, O, Wells, M.N, Moldt, M, Witte, G, Butryn, A, Wendler, P, Beckmann, R, Auble, D.T, Hopfner, K.-P. | Deposit date: | 2010-08-09 | Release date: | 2011-07-13 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structure and mechanism of the Swi2/Snf2 remodeller Mot1 in complex with its substrate TBP. Nature, 475, 2011
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3QZR
| Human enterovirus 71 3C protease mutant E71A in complex with rupintrivir | Descriptor: | 1,2-ETHANEDIOL, 3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER | Authors: | Wang, J, Fan, T, Yao, X, Wu, Z, Guo, L, Lei, X, Wang, J, Wang, M, Jin, Q, Cui, S. | Deposit date: | 2011-03-07 | Release date: | 2011-08-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.039 Å) | Cite: | Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues. J.Virol., 85, 2011
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3QZQ
| Human enterovirus 71 3C protease mutant E71D in complex with rupintrivir | Descriptor: | 3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER | Authors: | Wang, J, Fan, T, Yao, X, Wu, Z, Guo, L, Lei, X, Wang, J, Wang, M, Jin, Q, Cui, S. | Deposit date: | 2011-03-07 | Release date: | 2011-08-10 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (1.7001 Å) | Cite: | Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues. J.Virol., 85, 2011
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3R0F
| Human enterovirus 71 3C protease mutant H133G in complex with rupintrivir | Descriptor: | 1,2-ETHANEDIOL, 3C protein, 4-{2-(4-FLUORO-BENZYL)-6-METHYL-5-[(5-METHYL-ISOXAZOLE-3-CARBONYL)-AMINO]-4-OXO-HEPTANOYLAMINO}-5-(2-OXO-PYRROLIDIN-3-YL)-PENTANOIC ACID ETHYL ESTER | Authors: | Wang, J, Fan, T, Yao, X, Wu, Z, Guo, L, Lei, X, Wang, J, Wang, M, Jin, Q, Cui, S. | Deposit date: | 2011-03-08 | Release date: | 2011-08-10 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.3083 Å) | Cite: | Crystal Structures of Enterovirus 71 3C Protease Complexed with Rupintrivir Reveal the Roles of Catalytically Important Residues. J.Virol., 85, 2011
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7WYP
| Structure of the SARS-COV-2 main protease with EN102 inhibitor | Descriptor: | 3C-like proteinase, N-(1,3-benzothiazol-2-ylmethyl)-N-cyclopropyl-prop-2-enamide | Authors: | Qin, B, Hou, P, Gao, X, Cui, S. | Deposit date: | 2022-02-16 | Release date: | 2022-06-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease. Acta Pharm Sin B, 12, 2022
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7WYO
| Structure of the EV71 3Cpro with 338 inhibitor | Descriptor: | 3C protein, N-methyl-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-ylmethyl)prop-2-enamide | Authors: | Qin, B, Hou, P, Gao, X, Cui, S. | Deposit date: | 2022-02-16 | Release date: | 2022-06-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.402 Å) | Cite: | Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease. Acta Pharm Sin B, 12, 2022
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7WYL
| Structure of the EV71 3Cpro with 337 inhibitor | Descriptor: | 3C protein, N-methyl-N-[[4-(trifluoromethyl)-1,3-thiazol-2-yl]methyl]prop-2-enamide | Authors: | Qin, B, Hou, P, Gao, X, Cui, S. | Deposit date: | 2022-02-16 | Release date: | 2022-06-22 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.31 Å) | Cite: | Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease. Acta Pharm Sin B, 12, 2022
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