7WYO

Structure of the EV71 3Cpro with 338 inhibitor

Summary for 7WYO

Entry DOI	10.2210/pdb7wyo/pdb
Descriptor	3C protein, N-methyl-N-(4,5,6,7-tetrahydro-1,3-benzothiazol-2-ylmethyl)prop-2-enamide (3 entities in total)
Functional Keywords	ev71 3cpro, inhibitor, viral protein, hydrolase-hydrolase inhibitor complex
Biological source	Enterovirus A71
Total number of polymer chains	2
Total formula weight	41279.35
Authors	Qin, B.,Hou, P.,Gao, X.,Cui, S. (deposition date: 2022-02-16, release date: 2022-06-22, Last modification date: 2023-11-29)
Primary citation	Qin, B.,Craven, G.B.,Hou, P.,Chesti, J.,Lu, X.,Child, E.S.,Morgan, R.M.L.,Niu, W.,Zhao, L.,Armstrong, A.,Mann, D.J.,Cui, S. Acrylamide fragment inhibitors that induce unprecedented conformational distortions in enterovirus 71 3C and SARS-CoV-2 main protease. Acta Pharm Sin B, 12:3924-3933, 2022 Cited by PubMed: 35702321 DOI: 10.1016/j.apsb.2022.06.002 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.402 Å)

Structure validation