HIV-gp41 fusion inhibitor Sifuvirtide

Summary for 3VIE

DescriptorEnvelope glycoprotein gp160, Sifuvirtide (3 entities in total)
Functional Keywords6-helix bundle, membrane fusion inhibition, hiv, viral protein-antiviral protein complex, viral protein/antiviral protein
Biological sourceHuman immunodeficiency virus 1
Total number of polymer chains6
Total molecular weight26609.59
Yao, X.,Waltersperger, S.,Wang, M.T.,Cui, S. (deposition date: 2011-09-29, release date: 2012-01-18, Last modification date: 2013-07-24)
Primary citation
Yao, X.,Chong, H.,Zhang, C.,Waltersperger, S.,Wang, M.,Cui, S.,He, Y.
Broad antiviral activity and crystal structure of HIV-1 fusion inhibitor sifuvirtide
J.Biol.Chem., 287:6788-6796, 2012
PubMed: 22228771 (PDB entries with the same primary citation)
DOI: 10.1074/jbc.M111.317883
MImport into Mendeley
Experimental method

Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.215180.5%4.0%1.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution
Download full validation reportDownload