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4R7L
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BU of 4r7l by Molmil
Structure of Human Leukotriene A4 Hydrolase in complex with inhibitor H1
Descriptor: ACETATE ION, GLYCEROL, IMIDAZOLE, ...
Authors:Ouyang, P, Cui, K, Lu, W, Huang, J.
Deposit date:2014-08-27
Release date:2015-11-25
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.66 Å)
Cite:Human Leukotriene A4 Hydrolase in complex with SAHA
To be Published
4E9A
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BU of 4e9a by Molmil
Structure of Peptide Deformylase form Helicobacter Pylori in complex with inhibitor
Descriptor: 2-phenylethyl (2E)-3-(3,4-dihydroxyphenyl)prop-2-enoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, COBALT (II) ION, ...
Authors:Cui, K, Zhu, L, Lu, W, Huang, J.
Deposit date:2012-03-20
Release date:2013-04-24
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.662 Å)
Cite:Identification of Novel Peptide Deformylase Inhibitors from Natural Products
To be Published
4CC6
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BU of 4cc6 by Molmil
Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase
Descriptor: 2-{[2-(1H-pyrazolo[3,4-c]pyridin-3-yl)-6-(trifluoromethyl)pyridin-4-yl]amino}ethanol, DNA LIGASE, SULFATE ION
Authors:Howard, S, Amin, N, Benowitz, A.B, Chiarparin, E, Cui, H, Deng, X, Heightman, T.D, Holmes, D.J, Hopkins, A, Huang, J, Jin, Q, Kreatsoulas, C, Martin, A.C.L, Massey, F, McCloskey, L, Mortenson, P.N, Pathuri, P, Tisi, D, Williams, P.A.
Deposit date:2013-10-18
Release date:2014-06-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Fragment-Based Discovery of 6-Azaindazoles as Inhibitors of Bacterial DNA Ligase.
Acs Med.Chem.Lett., 4, 2013
4CC5
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BU of 4cc5 by Molmil
Fragment-Based Discovery of 6 Azaindazoles As Inhibitors of Bacterial DNA Ligase
Descriptor: 2-chloranyl-6-(1H-1,2,4-triazol-3-yl)pyrazine, DNA LIGASE, SULFATE ION
Authors:Howard, S, Amin, N, Benowitz, A.B, Chiarparin, E, Cui, H, Deng, X, Heightman, T.D, Holmes, D.J, Hopkins, A, Huang, J, Jin, Q, Kreatsoulas, C, Martin, A.C.L, Massey, F, McCloskey, L, Mortenson, P.N, Pathuri, P, Tisi, D, Williams, P.A.
Deposit date:2013-10-18
Release date:2014-06-18
Last modified:2023-12-20
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Fragment-Based Discovery of 6-Azaindazoles as Inhibitors of Bacterial DNA Ligase.
Acs Med.Chem.Lett., 4, 2013
4E9B
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BU of 4e9b by Molmil
Structure of Peptide Deformylase form Helicobacter Pylori in complex with actinonin
Descriptor: 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACTINONIN, COBALT (II) ION, ...
Authors:Cui, K, Zhu, L, Lu, W, Huang, J.
Deposit date:2012-03-20
Release date:2013-04-24
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Identification of Novel Peptide Deformylase Inhibitors from Natural Products
To be Published
1DT0
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BU of 1dt0 by Molmil
CLONING, SEQUENCE, AND CRYSTALLOGRAPHIC STRUCTURE OF RECOMBINANT IRON SUPEROXIDE DISMUTASE FROM PSEUDOMONAS OVALIS
Descriptor: FE (III) ION, SUPEROXIDE DISMUTASE
Authors:Bond, C.J, Huang, J, Hajduk, R, Flick, K, Heath, P, Stoddard, B.L.
Deposit date:2000-01-10
Release date:2000-12-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Cloning, sequence and crystallographic structure of recombinant iron superoxide dismutase from Pseudomonas ovalis.
Acta Crystallogr.,Sect.D, 56, 2000
1EMS
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BU of 1ems by Molmil
CRYSTAL STRUCTURE OF THE C. ELEGANS NITFHIT PROTEIN
Descriptor: (4S)-2-METHYL-2,4-PENTANEDIOL, ETHYL MERCURY ION, NIT-FRAGILE HISTIDINE TRIAD FUSION PROTEIN, ...
Authors:Pace, H.C, Hodawadekar, S.C, Draganescu, A, Huang, J, Bieganowski, P, Pekarsky, Y, Croce, C.M, Brenner, C.
Deposit date:2000-03-17
Release date:2000-07-20
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Crystal structure of the worm NitFhit Rosetta Stone protein reveals a Nit tetramer binding two Fhit dimers.
Curr.Biol., 10, 2000
4KN8
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BU of 4kn8 by Molmil
Crystal structure of Bs-TpNPPase
Descriptor: Thermostable NPPase
Authors:Guo, Z, Wang, F, Huang, J, Gong, W, Ji, C.
Deposit date:2013-05-09
Release date:2014-04-09
Last modified:2023-11-08
Method:X-RAY DIFFRACTION (1.502 Å)
Cite:Crystal Structure of Thermostable p-nitrophenylphosphatase from Bacillus Stearothermophilus (Bs-TpNPPase)
PROTEIN PEPT.LETT., 21, 2014
2IEL
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BU of 2iel by Molmil
CRYSTAL STRUCTURE OF TT0030 from Thermus Thermophilus
Descriptor: Hypothetical Protein TT0030
Authors:Zhu, J, Huang, J, Stepanyuk, G, Chen, L, Chang, J, Zhao, M, Xu, H, Liu, Z.J, Rose, J.P, Wang, B.C, Southeast Collaboratory for Structural Genomics (SECSG)
Deposit date:2006-09-19
Release date:2006-11-14
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:CRYSTAL STRUCTURE OF TT0030 from Thermus Thermophilus AT 1.6 ANGSTROMS RESOLUTION
To be Published
3TYH
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BU of 3tyh by Molmil
Crystal structure of oxo-cupper clusters binding to ferric binding protein from Neisseria gonorrhoeae
Descriptor: COPPER (II) ION, FbpA protein
Authors:Chen, W.J, Wang, H.F, Zhou, C.J, Ye, D.R, Huang, J, Tan, X.S, Zhong, W.Q.
Deposit date:2011-09-26
Release date:2012-09-26
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of oxo-cupper clusters binding to ferric binding protein from Neisseria gonorrhoeae
To be Published
2JTK
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BU of 2jtk by Molmil
A functional domain of a Wnt signal protein
Descriptor: Dickkopf-related protein 2
Authors:Chen, L, Shao, Y, Huang, J, Zheng, J.
Deposit date:2007-08-02
Release date:2008-07-08
Last modified:2022-03-16
Method:SOLUTION NMR
Cite:Structural insight into the mechanisms of wnt signaling antagonism by dkk
J.Biol.Chem., 283, 2008
5Z2S
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BU of 5z2s by Molmil
Crystal structure of DUX4-HD2 domain
Descriptor: Double homeobox protein 4
Authors:Dong, X, Zhang, W, Wu, H, Huang, J, Zhang, M, Wang, P, Zhang, H, Chen, Z, Chen, S, Meng, G.
Deposit date:2018-01-03
Release date:2018-04-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structural basis of DUX4/IGH-driven transactivation.
Leukemia, 32, 2018
5Z2T
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BU of 5z2t by Molmil
Crystal structure of DNA-bound DUX4-HD2
Descriptor: 5'-D(*TP*TP*CP*TP*AP*AP*TP*CP*TP*AP*AP*TP*CP*TP*T)-3', 5'-D(P*AP*AP*GP*AP*TP*TP*AP*GP*AP*TP*TP*AP*GP*T)-3', Double homeobox protein 4
Authors:Dong, X, Zhang, W, Wu, H, Huang, J, Zhang, M, Wang, P, Zhang, H, Chen, Z, Chen, S, Meng, G.
Deposit date:2018-01-04
Release date:2018-04-04
Last modified:2023-11-22
Method:X-RAY DIFFRACTION (2.623 Å)
Cite:Structural basis of DUX4/IGH-driven transactivation.
Leukemia, 32, 2018
7DW5
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BU of 7dw5 by Molmil
Crystal structure of DUX4 HD1-HD2 domain complexed with ERG sites
Descriptor: BROMIDE ION, DNA (5'-D(P*CP*GP*AP*CP*TP*TP*GP*AP*TP*GP*AP*GP*AP*TP*TP*AP*GP*AP*CP*TP*G)-3'), Double homeobox protein 4-like protein 2
Authors:Zhang, H, Cheng, N, Li, Z, Zhang, W, Dong, X, Huang, J, Meng, G.
Deposit date:2021-01-15
Release date:2021-11-03
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.83 Å)
Cite:DNA crosslinking and recombination-activating genes 1/2 (RAG1/2) are required for oncogenic splicing in acute lymphoblastic leukemia.
Cancer Commun (Lond), 41, 2021
7Y7Y
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BU of 7y7y by Molmil
Cryo-EM structure of human GABA transporter GAT1 bound with nipecotic acid in NaCl solution in an inward-occluded state at 2.4 angstrom
Descriptor: (3R)-piperidine-3-carboxylic acid, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
Authors:Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C.
Deposit date:2022-06-22
Release date:2023-04-26
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Molecular basis for substrate recognition and transport of human GABA transporter GAT1.
Nat.Struct.Mol.Biol., 30, 2023
7Y7V
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BU of 7y7v by Molmil
Cryo-EM structure of human apo GABA transporter GAT1 in an inward-open state
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Sodium- and chloride-dependent GABA transporter 1
Authors:Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C.
Deposit date:2022-06-22
Release date:2023-04-26
Last modified:2023-08-16
Method:ELECTRON MICROSCOPY (2.2 Å)
Cite:Molecular basis for substrate recognition and transport of human GABA transporter GAT1.
Nat.Struct.Mol.Biol., 30, 2023
7Y7Z
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BU of 7y7z by Molmil
Cryo-EM structure of human GABA transporter GAT1 bound with tiagabine in NaCl solution in an inward-open state at 3.2 angstrom
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, Sodium- and chloride-dependent GABA transporter 1, ...
Authors:Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C.
Deposit date:2022-06-22
Release date:2023-04-26
Last modified:2023-11-29
Method:ELECTRON MICROSCOPY (3.2 Å)
Cite:Molecular basis for substrate recognition and transport of human GABA transporter GAT1.
Nat.Struct.Mol.Biol., 30, 2023
7Y7W
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BU of 7y7w by Molmil
Cryo-EM structure of human GABA transporter GAT1 bound with GABA in NaCl solution in an inward-occluded state at 2.4 angstrom
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, GAMMA-AMINO-BUTANOIC ACID, ...
Authors:Zhu, A, Huang, J, Kong, F, Tan, J, Lei, J, Yuan, Y, Yan, C.
Deposit date:2022-06-22
Release date:2023-04-26
Last modified:2023-11-15
Method:ELECTRON MICROSCOPY (2.4 Å)
Cite:Molecular basis for substrate recognition and transport of human GABA transporter GAT1.
Nat.Struct.Mol.Biol., 30, 2023
7JJO
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BU of 7jjo by Molmil
Structural Basis of the Activation of Heterotrimeric Gs-protein by Isoproterenol-bound Beta1-Adrenergic Receptor
Descriptor: Beta1-Adrenergic Receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ...
Authors:Su, M, Zhu, L, Zhang, Y, Paknejad, N, Dey, R, Huang, J, Lee, M.Y, Williams, D, Jordan, K.D, Eng, E.T, Ernst, O.P, Meyerson, J.R, Hite, R.K, Walz, T, Liu, W, Huang, X.Y.
Deposit date:2020-07-27
Release date:2020-09-02
Last modified:2020-10-14
Method:ELECTRON MICROSCOPY (2.6 Å)
Cite:Structural Basis of the Activation of Heterotrimeric Gs-Protein by Isoproterenol-Bound beta 1 -Adrenergic Receptor.
Mol.Cell, 80, 2020
6J3N
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BU of 6j3n by Molmil
RORgammat LBD complexed with Ursonic Acid and SRC2.2
Descriptor: (5beta)-3-oxours-12-en-28-oic acid, LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, Nuclear receptor ROR-gamma
Authors:Liu, Z.H, Huang, J, Tang, Y.
Deposit date:2019-01-05
Release date:2020-01-15
Last modified:2024-03-27
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structure of human RORgammat LBD with SCR2.2 at 1.99 Angstroms resolution
To Be Published
6J99
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BU of 6j99 by Molmil
Cryo-EM structure of human DOT1L in complex with an H2B-monoubiquitinated nucleosome
Descriptor: DNA (144-MER), DNA (145-MER), Histone H2A, ...
Authors:Yao, T, Huang, J.
Deposit date:2019-01-22
Release date:2019-02-27
Last modified:2019-04-10
Method:ELECTRON MICROSCOPY (4.1 Å)
Cite:Structural basis of the crosstalk between histone H2B monoubiquitination and H3 lysine 79 methylation on nucleosome.
Cell Res., 29, 2019
2JZI
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BU of 2jzi by Molmil
Structure of Calmodulin complexed with the Calmodulin Binding Domain of Calcineurin
Descriptor: CALCIUM ION, Calmodulin, Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform
Authors:Chyan, C, Huang, J, Irene, D, Lin, T.
Deposit date:2008-01-09
Release date:2009-01-13
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Structure of Calmodulin complexed with the Calmodulin Binding Domain of Calcineurin
To be Published
7E3M
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BU of 7e3m by Molmil
RORgamma LBD complexed with Panaxatriol and SRC2.2
Descriptor: (3R,5R,6S,8R,9R,10R,12R,13R,14R,17S)-4,4,8,10,14-pentamethyl-17-[(2R)-2,6,6-trimethyloxan-2-yl]-2,3,5,6,7,9,11,12,13,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthrene-3,6,12-triol, LYS-ILE-LEU-HIS-ARG-LEU-LEU-GLN, Nuclear receptor ROR-gamma
Authors:Liu, Z.H, Huang, J, Lu, W.Q, Tang, Y, Wu, Z.R.
Deposit date:2021-02-09
Release date:2022-03-23
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Structure of human RORgammat LBD with SRC2.2 at 2.80 Angstroms resolution
To Be Published
7CWY
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BU of 7cwy by Molmil
Crystal structure of a tyrosine decarboxylase from Enterococcus faecalis in complex with the cofactor PLP
Descriptor: Decarboxylase
Authors:Yu, X, Gong, M, Huang, J, Liu, W, Chen, C, Guo, R.
Deposit date:2020-09-01
Release date:2021-09-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Crystal structure of a tyrosine decarboxylase from Enterococcus faecalis in complex with the cofactor PLP
to be published
7CX0
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BU of 7cx0 by Molmil
Crystal structure of a tyrosine decarboxylase from Enterococcus faecalis in complex with the cofactor PLP and inhibitor carbidopa
Descriptor: CARBIDOPA, Decarboxylase, PYRIDOXAL-5'-PHOSPHATE
Authors:Yu, X, Gong, M, Huang, J, Liu, W, Chen, C, Guo, R.
Deposit date:2020-09-01
Release date:2021-09-01
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (2.66 Å)
Cite:Crystal structure of a tyrosine decarboxylase from Enterococcus faecalis in complex with the cofactor PLP and inhibitor carbidopa
to be published

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