7W0L
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![BU of 7w0l by Molmil](/molmil-images/mine/7w0l) | Cryo-EM structure of a dimeric GPCR-Gi complex with small molecule | Descriptor: | (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Yue, Y, Liu, L.E, Wu, L.J, Xu, F, Hanson, M. | Deposit date: | 2021-11-18 | Release date: | 2022-07-27 | Last modified: | 2022-08-03 | Method: | ELECTRON MICROSCOPY (3.57 Å) | Cite: | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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7K6M
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![BU of 7k6m by Molmil](/molmil-images/mine/7k6m) | Crystal structure of PI3Kalpha selective Inhibitor PF-06843195 | Descriptor: | 2,2-difluoroethyl (3S)-3-{[2'-amino-5-fluoro-2-(morpholin-4-yl)[4,5'-bipyrimidin]-6-yl]amino}-3-(hydroxymethyl)pyrrolidine-1-carboxylate, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | Authors: | Chen, P, Brooun, A, Deng, Y.L, Grodsky, N, Kaiser, S.E. | Deposit date: | 2020-09-21 | Release date: | 2021-01-06 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.413 Å) | Cite: | Structure-Based Drug Design and Synthesis of PI3K alpha-Selective Inhibitor (PF-06843195). J.Med.Chem., 64, 2021
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7W0O
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![BU of 7w0o by Molmil](/molmil-images/mine/7w0o) | Cryo-EM structure of a monomeric GPCR-Gi complex with peptide | Descriptor: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | Deposit date: | 2021-11-18 | Release date: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.78 Å) | Cite: | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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7W0M
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![BU of 7w0m by Molmil](/molmil-images/mine/7w0m) | Cryo-EM structure of a monomeric GPCR-Gi complex with small molecule | Descriptor: | (1R,2S)-N-[4-(2,6-dimethoxyphenyl)-5-(6-methylpyridin-2-yl)-1,2,4-triazol-3-yl]-1-(5-methylpyrimidin-2-yl)-1-oxidanyl-propane-2-sulfonamide, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | Deposit date: | 2021-11-18 | Release date: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.71 Å) | Cite: | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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7W0P
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![BU of 7w0p by Molmil](/molmil-images/mine/7w0p) | Cryo-EM structure of a GPCR-Gi complex with peptide | Descriptor: | Apelin receptor early endogenous ligand, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Xu, F, Yue, Y, Liu, L.E, Wu, L.J, Hanson, M. | Deposit date: | 2021-11-18 | Release date: | 2022-07-27 | Method: | ELECTRON MICROSCOPY (3.16 Å) | Cite: | Structural insight into apelin receptor-G protein stoichiometry. Nat.Struct.Mol.Biol., 29, 2022
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6JFU
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![BU of 6jfu by Molmil](/molmil-images/mine/6jfu) | Crystal structure of Nme2Cas9 in complex with sgRNA and target DNA (AGGCCC PAM) | Descriptor: | 1,2-ETHANEDIOL, CRISPR-associated endonuclease Cas9, non-target strand, ... | Authors: | Sun, W, Yang, J, Cheng, Z, Liu, C, Wang, K, Huang, X, Wang, Y. | Deposit date: | 2019-02-12 | Release date: | 2019-11-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Mol.Cell, 76, 2019
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5GOG
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![BU of 5gog by Molmil](/molmil-images/mine/5gog) | Lys29-linked di-ubiquitin | Descriptor: | D-ubiquitin, Ubiquitin | Authors: | Gao, S, Pan, M, Zheng, Y. | Deposit date: | 2016-07-27 | Release date: | 2016-11-02 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.977 Å) | Cite: | Monomer/Oligomer Quasi-Racemic Protein Crystallography J.Am.Chem.Soc., 138, 2016
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6KC7
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![BU of 6kc7 by Molmil](/molmil-images/mine/6kc7) | Crystal structure of Nme1Cas9 in complex with sgRNA and target DNA (ATATGATT PAM) in seed-base paring state | Descriptor: | CRISPR-associated endonuclease Cas9, DNA (5'-D(*AP*TP*AP*TP*GP*AP*TP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*AP*TP*CP*AP*TP*AP*TP*GP*TP*AP*AP*AP*GP*TP*T)-3'), ... | Authors: | Sun, W, Yang, J, Cheng, Z, Liu, C, Wang, K, Huang, X, Wang, Y. | Deposit date: | 2019-06-27 | Release date: | 2019-11-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (3.3 Å) | Cite: | Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Mol.Cell, 76, 2019
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6KC8
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![BU of 6kc8 by Molmil](/molmil-images/mine/6kc8) | Crystal structure of WT Nme1Cas9 in complex with sgRNA and target DNA (ATATGATT PAM) in post-cleavage state | Descriptor: | CRISPR-associated endonuclease Cas9, DNA (5'-D(*AP*TP*AP*TP*GP*AP*TP*TP*TP*TP*A)-3'), DNA (5'-D(*TP*AP*AP*AP*AP*TP*CP*AP*TP*AP*TP*GP*TP*A)-3'), ... | Authors: | Sun, W, Yang, J, Cheng, Z, Liu, C, Wang, K, Huang, X, Wang, Y. | Deposit date: | 2019-06-27 | Release date: | 2019-11-06 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structures of Neisseria meningitidis Cas9 Complexes in Catalytically Poised and Anti-CRISPR-Inhibited States. Mol.Cell, 76, 2019
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3QK0
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![BU of 3qk0 by Molmil](/molmil-images/mine/3qk0) | Crystal structure of PI3K-gamma in complex with benzothiazole 82 | Descriptor: | N-[6-(6-chloro-5-{[(4-fluorophenyl)sulfonyl]amino}pyridin-3-yl)-1,3-benzothiazol-2-yl]acetamide, Phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma isoform, SULFATE ION | Authors: | Whittington, D.A, Tang, J, Yakowec, P. | Deposit date: | 2011-01-31 | Release date: | 2011-03-30 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.85 Å) | Cite: | Discovery and Optimization of a Series of Benzothiazole Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitors. J.Med.Chem., 54, 2011
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7L2C
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![BU of 7l2c by Molmil](/molmil-images/mine/7l2c) | Crystallographic structure of neutralizing antibody 2-51 in complex with SARS-CoV-2 spike N-terminal domain (NTD) | Descriptor: | 2-51 heavy chain, 2-51 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Cerutti, G, Reddem, E.R, Shapiro, L. | Deposit date: | 2020-12-16 | Release date: | 2021-02-10 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.65 Å) | Cite: | Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite. Cell Host Microbe, 29, 2021
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7L2E
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![BU of 7l2e by Molmil](/molmil-images/mine/7l2e) | |
7L2F
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![BU of 7l2f by Molmil](/molmil-images/mine/7l2f) | |
7L2D
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![BU of 7l2d by Molmil](/molmil-images/mine/7l2d) | |
7SEG
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![BU of 7seg by Molmil](/molmil-images/mine/7seg) | Crystal structure of the complex of CD16A bound by an anti-CD16A Fab | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, GLYCEROL, ... | Authors: | Kiefer, J.R, Wallweber, H.A, Polson, A.G. | Deposit date: | 2021-09-30 | Release date: | 2021-11-24 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.156 Å) | Cite: | A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma. Leukemia, 36, 2022
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7L57
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![BU of 7l57 by Molmil](/molmil-images/mine/7l57) | Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-15 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Rapp, M, Shapiro, L. | Deposit date: | 2020-12-21 | Release date: | 2021-04-14 | Last modified: | 2021-04-21 | Method: | ELECTRON MICROSCOPY (5.87 Å) | Cite: | Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class. Cell Rep, 35, 2021
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7L56
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![BU of 7l56 by Molmil](/molmil-images/mine/7l56) | Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab 2-43 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab 2-43 variable domain heavy chain, ... | Authors: | Rapp, M, Shapiro, L. | Deposit date: | 2020-12-21 | Release date: | 2021-04-14 | Last modified: | 2023-04-05 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class. Cell Rep, 35, 2021
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7L58
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![BU of 7l58 by Molmil](/molmil-images/mine/7l58) | Cryo-EM structure of the SARS-CoV-2 spike glycoprotein bound to Fab H4 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab H4 variable domain heavy chain, ... | Authors: | Rapp, M, Shapiro, L. | Deposit date: | 2020-12-21 | Release date: | 2021-04-14 | Last modified: | 2021-04-21 | Method: | ELECTRON MICROSCOPY (5.07 Å) | Cite: | Modular basis for potent SARS-CoV-2 neutralization by a prevalent VH1-2-derived antibody class. Cell Rep, 35, 2021
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7LQV
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![BU of 7lqv by Molmil](/molmil-images/mine/7lqv) | Cryo-EM structure of NTD-directed neutralizing antibody 4-8 Fab in complex with SARS-CoV-2 S2P spike | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-8 Heavy Chain, 4-8 Light chain, ... | Authors: | Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L. | Deposit date: | 2021-02-15 | Release date: | 2021-03-24 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Potent SARS-CoV-2 Neutralizing Antibodies Directed Against Spike N-Terminal Domain Target a Single Supersite Cell Host Microbe, 2021
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7LQW
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![BU of 7lqw by Molmil](/molmil-images/mine/7lqw) | Cryo-EM structure of NTD-directed neutralizing antibody 2-17 Fab in complex with SARS-CoV-2 S2P spike | Descriptor: | 2-17 Heavy Chain, 2-17 Light Chain, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Gorman, J, Rapp, M, Kwong, P.D, Shapiro, L. | Deposit date: | 2021-02-15 | Release date: | 2021-03-24 | Last modified: | 2021-05-26 | Method: | ELECTRON MICROSCOPY (4.47 Å) | Cite: | Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite. Cell Host Microbe, 29, 2021
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7TMD
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![BU of 7tmd by Molmil](/molmil-images/mine/7tmd) | |
7TMB
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![BU of 7tmb by Molmil](/molmil-images/mine/7tmb) | |
7TMG
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![BU of 7tmg by Molmil](/molmil-images/mine/7tmg) | |
7S05
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![BU of 7s05 by Molmil](/molmil-images/mine/7s05) | Cryo-EM structure of human GlcNAc-1-phosphotransferase A2B2 subcomplex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, ... | Authors: | Li, H, Li, H. | Deposit date: | 2021-08-30 | Release date: | 2022-03-30 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Structure of the human GlcNAc-1-phosphotransferase alpha beta subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation. Nat.Struct.Mol.Biol., 29, 2022
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7S06
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![BU of 7s06 by Molmil](/molmil-images/mine/7s06) | Cryo-EM structure of human GlcNAc-1-phosphotransferase A2B2 subcomplex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, N-acetylglucosamine-1-phosphotransferase subunits alpha/beta | Authors: | Li, H, Li, H. | Deposit date: | 2021-08-30 | Release date: | 2022-03-30 | Last modified: | 2022-04-27 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Structure of the human GlcNAc-1-phosphotransferase alpha beta subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation. Nat.Struct.Mol.Biol., 29, 2022
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