7S05

Cryo-EM structure of human GlcNAc-1-phosphotransferase A2B2 subcomplex

Summary for 7S05

• Entry DOI: 10.2210/pdb7s05/pdb
• EMDB information: 24784
• Descriptor: N-acetylglucosamine-1-phosphotransferase subunits alpha/beta, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... (4 entities in total)
• Functional Keywords: glcnac-1-phosphotransferase, lysosomal hydrolases, mannose 6-phosphate trafficking pathway, transferase
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 2
• Total formula weight: 272680.01

Authors

Li, H.,Li, H. (deposition date: 2021-08-30, release date: 2022-03-30, Last modification date: 2022-04-27)

• Primary citation: Li, H.,Lee, W.S.,Feng, X.,Bai, L.,Jennings, B.C.,Liu, L.,Doray, B.,Canfield, W.M.,Kornfeld, S.,Li, H.; Structure of the human GlcNAc-1-phosphotransferase alpha beta subunits reveals regulatory mechanism for lysosomal enzyme glycan phosphorylation.; Nat.Struct.Mol.Biol., 29:348-356, 2022; PubMed: 35332324; DOI: 10.1038/s41594-022-00748-0

Experimental method

ELECTRON MICROSCOPY (3.1 Å)