7L2C

Crystallographic structure of neutralizing antibody 2-51 in complex with SARS-CoV-2 spike N-terminal domain (NTD)

Summary for 7L2C

• Entry DOI: 10.2210/pdb7l2c/pdb
• Descriptor: Spike glycoprotein, 2-51 heavy chain, 2-51 light chain, ... (10 entities in total)
• Functional Keywords: covid-19, sars-cov-2, viral protein, spike glycoprotein, n-terminal domain, ntd, neutralizing antibody, 2-51, fab, immune system, immune system-viral protein complex, immune system/viral protein
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 6
• Total formula weight: 177328.13

Authors

Cerutti, G.,Reddem, E.R.,Shapiro, L. (deposition date: 2020-12-16, release date: 2021-02-10, Last modification date: 2023-10-18)

• Primary citation: Cerutti, G.,Guo, Y.,Zhou, T.,Gorman, J.,Lee, M.,Rapp, M.,Reddem, E.R.,Yu, J.,Bahna, F.,Bimela, J.,Huang, Y.,Katsamba, P.S.,Liu, L.,Nair, M.S.,Rawi, R.,Olia, A.S.,Wang, P.,Zhang, B.,Chuang, G.Y.,Ho, D.D.,Sheng, Z.,Kwong, P.D.,Shapiro, L.; Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite.; Cell Host Microbe, 29:819-, 2021; PubMed: 33789084; DOI: 10.1016/j.chom.2021.03.005

Experimental method

X-RAY DIFFRACTION (3.65 Å)