7SEG

Crystal structure of the complex of CD16A bound by an anti-CD16A Fab

Summary for 7SEG

• Entry DOI: 10.2210/pdb7seg/pdb
• Descriptor: anti-CD16a Fab light chain, anti-CD16A Fab heavy chain, Low affinity immunoglobulin gamma Fc region receptor III-A, ... (7 entities in total)
• Functional Keywords: antibody, fragment, cd16a, fab, antitumor protein
• Biological source: Homo sapiens (human); More
• Total number of polymer chains: 6
• Total formula weight: 146716.94

Authors

Kiefer, J.R.,Wallweber, H.A.,Polson, A.G. (deposition date: 2021-09-30, release date: 2021-11-24, Last modification date: 2024-04-03)

• Primary citation: Kakiuchi-Kiyota, S.,Ross, T.,Wallweber, H.A.,Kiefer, J.R.,Schutten, M.M.,Adedeji, A.O.,Cai, H.,Hendricks, R.,Cohen, S.,Myneni, S.,Liu, L.,Fullerton, A.,Corr, N.,Yu, L.,de Almeida Nagata, D.,Zhong, S.,Leong, S.R.,Li, J.,Nakamura, R.,Sumiyoshi, T.,Li, J.,Ovacik, A.M.,Zheng, B.,Dillon, M.,Spiess, C.,Wingert, S.,Rajkovic, E.,Ellwanger, K.,Reusch, U.,Polson, A.G.; A BCMA/CD16A bispecific innate cell engager for the treatment of multiple myeloma.; Leukemia, 36:1006-1014, 2022; PubMed: 35001074; DOI: 10.1038/s41375-021-01478-w

Experimental method

X-RAY DIFFRACTION (2.156 Å)