7L2E

Cryo-EM structure of NTD-directed neutralizing antibody 4-18 in complex with prefusion SARS-CoV-2 spike glycoprotein

Summary for 7L2E

• Entry DOI: 10.2210/pdb7l2e/pdb
• EMDB information: 23126
• Descriptor: Spike glycoprotein, 4-18 heavy chain, 4-18 light chain, ... (5 entities in total)
• Functional Keywords: neutralizing antibody, fusion protein, spike glycoprotein, covid-19, ntd, ntd-directed antibody, 4-18, viral protein, immune system, viral protein-immune system complex, viral protein/immune system
• Biological source: Severe acute respiratory syndrome coronavirus 2 (2019-nCoV); More
• Total number of polymer chains: 9
• Total formula weight: 586621.15

Authors

Cerutti, G.,Shapiro, L. (deposition date: 2020-12-16, release date: 2021-03-24, Last modification date: 2021-05-26)

• Primary citation: Cerutti, G.,Guo, Y.,Zhou, T.,Gorman, J.,Lee, M.,Rapp, M.,Reddem, E.R.,Yu, J.,Bahna, F.,Bimela, J.,Huang, Y.,Katsamba, P.S.,Liu, L.,Nair, M.S.,Rawi, R.,Olia, A.S.,Wang, P.,Zhang, B.,Chuang, G.Y.,Ho, D.D.,Sheng, Z.,Kwong, P.D.,Shapiro, L.; Potent SARS-CoV-2 neutralizing antibodies directed against spike N-terminal domain target a single supersite.; Cell Host Microbe, 29:819-, 2021; PubMed: 33789084; DOI: 10.1016/j.chom.2021.03.005

Experimental method

ELECTRON MICROSCOPY (2.97 Å)