6E3Y
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![BU of 6e3y by Molmil](/molmil-images/mine/6e3y) | Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor | Descriptor: | Calcitonin gene-related peptide 1, Calcitonin gene-related peptide type 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Liang, Y.L, Khoshouei, M, Deganutti, G, Glukhova, A, Koole, C, Peat, T.S, Radjainia, M, Plitzko, J.M, Baumeister, W, Miller, L.J, Hay, D.L, Christopoulos, A, Reynolds, C.A, Wootten, D, Sexton, P.M. | Deposit date: | 2018-07-16 | Release date: | 2018-09-19 | Last modified: | 2020-01-15 | Method: | ELECTRON MICROSCOPY (3.3 Å) | Cite: | Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor. Nature, 561, 2018
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2LET
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![BU of 2let by Molmil](/molmil-images/mine/2let) | AN 1H NMR DETERMINATION OF THE THREE DIMENSIONAL STRUCTURES OF MIRROR IMAGE FORMS OF A LEU-5 VARIANT OF THE TRYPSIN INHIBITOR ECBALLIUM ELATERIUM (EETI-II) | Descriptor: | TRYPSIN INHIBITOR II | Authors: | Nielsen, K.J, Alewood, D, Andrews, J, Kent, S.B.H, Craik, D.J. | Deposit date: | 1994-01-04 | Release date: | 1994-05-31 | Last modified: | 2017-11-29 | Method: | SOLUTION NMR | Cite: | An 1H NMR determination of the three-dimensional structures of mirror-image forms of a Leu-5 variant of the trypsin inhibitor from Ecballium elaterium (EETI-II). Protein Sci., 3, 1994
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7KI0
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![BU of 7ki0 by Molmil](/molmil-images/mine/7ki0) | Semaglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs protein | Descriptor: | 17-amino-10-oxo-3,6,12,15-tetraoxa-9-azaheptadecan-1-oic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhang, X, Belousoff, M.J, Danev, R, Sexton, P.M, Wootten, D. | Deposit date: | 2020-10-22 | Release date: | 2021-08-04 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes. Cell Rep, 36, 2021
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7KI1
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![BU of 7ki1 by Molmil](/molmil-images/mine/7ki1) | Taspoglutide-bound Glucagon-Like Peptide-1 (GLP-1) Receptor in Complex with Gs Protein | Descriptor: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhang, X, Belousoff, M.J, Danev, R, Sexton, P.M, Wootten, D. | Deposit date: | 2020-10-22 | Release date: | 2021-08-04 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Structure and dynamics of semaglutide- and taspoglutide-bound GLP-1R-Gs complexes. Cell Rep, 36, 2021
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7LCJ
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![BU of 7lcj by Molmil](/molmil-images/mine/7lcj) | PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex | Descriptor: | 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor | Authors: | Belousoff, M.J, Johnson, R.M, Drulyte, I, Yu, L, Kotecha, A, Danev, R, Wootten, D, Zhang, X, Sexton, P.M. | Deposit date: | 2021-01-11 | Release date: | 2021-01-20 | Last modified: | 2021-09-15 | Method: | ELECTRON MICROSCOPY (2.82 Å) | Cite: | Evolving cryo-EM structural approaches for GPCR drug discovery. Structure, 29, 2021
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7LCK
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![BU of 7lck by Molmil](/molmil-images/mine/7lck) | PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R) | Descriptor: | 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor | Authors: | Belousoff, M.J, Johnson, R.M, Drulyte, I, Yu, L, Kotecha, A, Danev, R, Wootten, D, Zhang, X, Sexton, P.M. | Deposit date: | 2021-01-11 | Release date: | 2021-01-20 | Last modified: | 2021-09-15 | Method: | ELECTRON MICROSCOPY (3.24 Å) | Cite: | Evolving cryo-EM structural approaches for GPCR drug discovery. Structure, 29, 2021
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7LCI
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![BU of 7lci by Molmil](/molmil-images/mine/7lci) | PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex | Descriptor: | 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Belousoff, M.J, Johnson, R.M, Drulyte, I, Yu, L, Kotecha, A, Danev, R, Wootten, D, Zhang, X, Sexton, P.M. | Deposit date: | 2021-01-11 | Release date: | 2021-01-20 | Last modified: | 2021-09-15 | Method: | ELECTRON MICROSCOPY (2.9 Å) | Cite: | Evolving cryo-EM structural approaches for GPCR drug discovery. Structure, 29, 2021
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5UZ7
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![BU of 5uz7 by Molmil](/molmil-images/mine/5uz7) | Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex | Descriptor: | Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Liang, Y.L, Khoshouei, M, Radjainia, M, Zhang, Y, Glukhova, A, Tarrasch, J, Thal, D.M, Furness, S.G.B, Christopoulos, G, Coudrat, T, Danev, R, Baumeister, W, Miller, L.J, Christopoulos, A, Kobilka, B.K, Wootten, D, Skiniotis, G, Sexton, P.M. | Deposit date: | 2017-02-24 | Release date: | 2017-05-03 | Last modified: | 2018-07-18 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Phase-plate cryo-EM structure of a class B GPCR-G-protein complex. Nature, 546, 2017
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6OWN
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![BU of 6own by Molmil](/molmil-images/mine/6own) | |
4EVN
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![BU of 4evn by Molmil](/molmil-images/mine/4evn) | |
1DE0
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![BU of 1de0 by Molmil](/molmil-images/mine/1de0) | |
1G5P
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![BU of 1g5p by Molmil](/molmil-images/mine/1g5p) | NITROGENASE IRON PROTEIN FROM AZOTOBACTER VINELANDII | Descriptor: | IRON/SULFUR CLUSTER, NITROGENASE IRON PROTEIN | Authors: | Strop, P, Takahara, P.M, Chiu, H.J, Angove, H.C, Burgess, B.K, Rees, D.C. | Deposit date: | 2000-11-01 | Release date: | 2001-01-31 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Crystal structure of the all-ferrous [4Fe-4S]0 form of the nitrogenase iron protein from Azotobacter vinelandii. Biochemistry, 40, 2001
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5L9A
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![BU of 5l9a by Molmil](/molmil-images/mine/5l9a) | L-threonine dehydrogenase from trypanosoma brucei. | Descriptor: | ACETATE ION, L-threonine 3-dehydrogenase | Authors: | Erskine, P.T, Cooper, J.B, Adjogatse, E, Kelly, J, Wood, S.P. | Deposit date: | 2016-06-09 | Release date: | 2016-06-22 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations. Acta Crystallogr D Struct Biol, 74, 2018
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3KTT
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![BU of 3ktt by Molmil](/molmil-images/mine/3ktt) | Atomic model of bovine TRiC CCT2(beta) subunit derived from a 4.0 Angstrom cryo-EM map | Descriptor: | T-complex protein 1 subunit beta | Authors: | Cong, Y, Baker, M.L, Ludtke, S.J, Frydman, J, Chiu, W. | Deposit date: | 2009-11-25 | Release date: | 2010-03-16 | Last modified: | 2024-02-21 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | 4.0-A resolution cryo-EM structure of the mammalian chaperonin TRiC/CCT reveals its unique subunit arrangement. Proc.Natl.Acad.Sci.USA, 107, 2010
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7S3I
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![BU of 7s3i by Molmil](/molmil-images/mine/7s3i) | Ex4-D-Ala bound to the glucagon-like peptide-1 receptor/g protein complex (conformer 2) | Descriptor: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Belousoff, M.J, Piper, S.J, Danev, R. | Deposit date: | 2021-09-07 | Release date: | 2022-01-05 | Last modified: | 2022-03-16 | Method: | ELECTRON MICROSCOPY (2.51 Å) | Cite: | Structural and functional diversity among agonist-bound states of the GLP-1 receptor. Nat.Chem.Biol., 18, 2022
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6X1A
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![BU of 6x1a by Molmil](/molmil-images/mine/6x1a) | Non peptide agonist PF-06882961, bound to Glucagon-Like peptide-1 (GLP-1) Receptor | Descriptor: | 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Belousoff, M.J, Zhang, X, Danev, R. | Deposit date: | 2020-05-18 | Release date: | 2020-09-09 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (2.5 Å) | Cite: | Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. Mol.Cell, 80, 2020
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6X19
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![BU of 6x19 by Molmil](/molmil-images/mine/6x19) | Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor | Descriptor: | 3-{(1S)-1-[5-(2,2-dimethylmorpholin-4-yl)-2-{(4S)-2-(4-fluoro-3,5-dimethylphenyl)-3-[3-(4-fluoro-1-methyl-1H-indazol-5-yl)-2-oxo-2,3-dihydro-1H-imidazol-1-yl]-4-methyl-2,4,6,7-tetrahydro-5H-pyrazolo[4,3-c]pyridine-5-carbonyl}-1H-indol-1-yl]butyl}-1,2,4-oxadiazol-5(4H)-one, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Belousoff, M.J, Zhang, X, Danev, R. | Deposit date: | 2020-05-18 | Release date: | 2020-09-09 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. Mol.Cell, 80, 2020
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6X18
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![BU of 6x18 by Molmil](/molmil-images/mine/6x18) | GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor | Descriptor: | Glucagon, Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Belousoff, M.J, Zhang, X, Danev, R. | Deposit date: | 2020-05-18 | Release date: | 2020-09-09 | Last modified: | 2020-11-18 | Method: | ELECTRON MICROSCOPY (2.1 Å) | Cite: | Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists. Mol.Cell, 80, 2020
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8F2A
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![BU of 8f2a by Molmil](/molmil-images/mine/8f2a) | Human Amylin3 Receptor in complex with Gs and Pramlintide analogue peptide San385 (Cluster 5 conformation) | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Calcitonin receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Cao, J, Sexton, P.M, Wootten, D.L, Radostin, D. | Deposit date: | 2022-11-07 | Release date: | 2023-08-02 | Last modified: | 2024-02-14 | Method: | ELECTRON MICROSCOPY (2.2 Å) | Cite: | Structural insight into selectivity of amylin and calcitonin receptor agonists. Nat.Chem.Biol., 20, 2024
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7S1M
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![BU of 7s1m by Molmil](/molmil-images/mine/7s1m) | |
6FMC
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![BU of 6fmc by Molmil](/molmil-images/mine/6fmc) | Neuropilin1-b1 domain in complex with EG01377, 0.9 Angstrom structure | Descriptor: | (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1 | Authors: | Yelland, T, Djordjevic, S, Fotinou, K, Selwood, D, Zachary, I, Frankel, P. | Deposit date: | 2018-01-30 | Release date: | 2018-10-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (0.9 Å) | Cite: | Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells. J. Med. Chem., 61, 2018
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6FMF
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![BU of 6fmf by Molmil](/molmil-images/mine/6fmf) | Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure | Descriptor: | (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, Neuropilin-1, trifluoroacetic acid | Authors: | Yelland, T, Djordjevic, S, Selwood, D, Zachary, I, Frankel, P. | Deposit date: | 2018-01-31 | Release date: | 2018-10-17 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.811 Å) | Cite: | Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells. J. Med. Chem., 61, 2018
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9AUC
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![BU of 9auc by Molmil](/molmil-images/mine/9auc) | Human Amylin1 Receptor in Complex with Gs and human Calcitonin Gene-Related Peptide | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, Calcitonin gene-related peptide 1, ... | Authors: | Cao, J, Belousoff, M.J, Wootten, D.L, Sexton, P.M. | Deposit date: | 2024-02-28 | Release date: | 2024-04-24 | Last modified: | 2024-05-22 | Method: | ELECTRON MICROSCOPY (2.4 Å) | Cite: | Cryo-EM Structure of the Human Amylin 1 Receptor in Complex with CGRP and Gs Protein. Biochemistry, 63, 2024
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5LC1
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![BU of 5lc1 by Molmil](/molmil-images/mine/5lc1) | L-threonine dehydrogenase from Trypanosoma brucei with NAD and the inhibitor pyruvate bound. | Descriptor: | ACETATE ION, BETA-MERCAPTOETHANOL, L-threonine 3-dehydrogenase, ... | Authors: | Erskine, P.T, Adjogatse, E, Wood, S.P, Cooper, J.B. | Deposit date: | 2016-06-18 | Release date: | 2016-07-27 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure and function of L-threonine-3-dehydrogenase from the parasitic protozoan Trypanosoma brucei revealed by X-ray crystallography and geometric simulations. Acta Crystallogr D Struct Biol, 74, 2018
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8F2B
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![BU of 8f2b by Molmil](/molmil-images/mine/8f2b) | Amylin 3 Receptor in complex with Gs and Pramlintide analogue peptide San45 | Descriptor: | (2S)-2-{[(1R)-1-hydroxyhexadecyl]oxy}-3-{[(1R)-1-hydroxyoctadecyl]oxy}propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Cao, J, Sexton, P.M, Wootten, D.L, Belousoff, M.J. | Deposit date: | 2022-11-07 | Release date: | 2023-08-02 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (2 Å) | Cite: | Structural insight into selectivity of amylin and calcitonin receptor agonists. Nat.Chem.Biol., 20, 2024
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