7LCJ

PF 06882961 bound to the glucagon-like peptide-1 receptor (GLP-1R):Gs complex

Summary for 7LCJ

Entry DOI	10.2210/pdb7lcj/pdb
Related	6X1A 7LCI
EMDB information	23275
Descriptor	Glucagon-like peptide 1 receptor, 2-[(4-{6-[(4-cyano-2-fluorophenyl)methoxy]pyridin-2-yl}piperidin-1-yl)methyl]-1-{[(2S)-oxetan-2-yl]methyl}-1H-benzimidazole-6-carboxylic acid (3 entities in total)
Functional Keywords	gpcr, small molecule agonist, membrane protein
Biological source	Homo sapiens (Human)
Total number of polymer chains	1
Total formula weight	57304.02
Authors	Belousoff, M.J.,Johnson, R.M.,Drulyte, I.,Yu, L.,Kotecha, A.,Danev, R.,Wootten, D.,Zhang, X.,Sexton, P.M. (deposition date: 2021-01-11, release date: 2021-01-20, Last modification date: 2021-09-15)
Primary citation	Zhang, X.,Johnson, R.M.,Drulyte, I.,Yu, L.,Kotecha, A.,Danev, R.,Wootten, D.,Sexton, P.M.,Belousoff, M.J. Evolving cryo-EM structural approaches for GPCR drug discovery. Structure, 29:963-, 2021 Cited by PubMed: 33957078 DOI: 10.1016/j.str.2021.04.008 PDB entries with the same primary citation
Experimental method	ELECTRON MICROSCOPY (2.82 Å)

Structure validation