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6FMF

Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure

Summary for 6FMF
Entry DOI10.2210/pdb6fmf/pdb
Related6FMC
DescriptorNeuropilin-1, (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, trifluoroacetic acid, ... (4 entities in total)
Functional Keywordssmall molecule inhibitor, vegf signaling, semaphorin signaling, angiogenesis, discoiding domain, signaling protein
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total formula weight18615.98
Authors
Yelland, T.,Djordjevic, S.,Selwood, D.,Zachary, I.,Frankel, P. (deposition date: 2018-01-31, release date: 2018-10-17, Last modification date: 2024-01-17)
Primary citationPowell, J.,Mota, F.,Steadman, D.,Soudy, C.,Miyauchi, J.T.,Crosby, S.,Jarvis, A.,Reisinger, T.,Winfield, N.,Evans, G.,Finniear, A.,Yelland, T.,Chou, Y.T.,Chan, A.W.E.,O'Leary, A.,Cheng, L.,Liu, D.,Fotinou, C.,Milagre, C.,Martin, J.F.,Jia, H.,Frankel, P.,Djordjevic, S.,Tsirka, S.E.,Zachary, I.C.,Selwood, D.L.
Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells.
J. Med. Chem., 61:4135-4154, 2018
Cited by
PubMed: 29648813
DOI: 10.1021/acs.jmedchem.8b00210
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.811 Å)
Structure validation

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