6FMF
Neuropilin-1 b1 domain in complex with EG01377; 2.8 Angstrom structure
Summary for 6FMF
Entry DOI | 10.2210/pdb6fmf/pdb |
Related | 6FMC |
Descriptor | Neuropilin-1, (2~{S})-2-[[3-[[5-[4-(aminomethyl)phenyl]-1-benzofuran-7-yl]sulfonylamino]thiophen-2-yl]carbonylamino]-5-carbamimidamido-pentanoic acid, trifluoroacetic acid, ... (4 entities in total) |
Functional Keywords | small molecule inhibitor, vegf signaling, semaphorin signaling, angiogenesis, discoiding domain, signaling protein |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 1 |
Total formula weight | 18615.98 |
Authors | Yelland, T.,Djordjevic, S.,Selwood, D.,Zachary, I.,Frankel, P. (deposition date: 2018-01-31, release date: 2018-10-17, Last modification date: 2024-01-17) |
Primary citation | Powell, J.,Mota, F.,Steadman, D.,Soudy, C.,Miyauchi, J.T.,Crosby, S.,Jarvis, A.,Reisinger, T.,Winfield, N.,Evans, G.,Finniear, A.,Yelland, T.,Chou, Y.T.,Chan, A.W.E.,O'Leary, A.,Cheng, L.,Liu, D.,Fotinou, C.,Milagre, C.,Martin, J.F.,Jia, H.,Frankel, P.,Djordjevic, S.,Tsirka, S.E.,Zachary, I.C.,Selwood, D.L. Small Molecule Neuropilin-1 Antagonists Combine Antiangiogenic and Antitumor Activity with Immune Modulation through Reduction of Transforming Growth Factor Beta (TGF beta ) Production in Regulatory T-Cells. J. Med. Chem., 61:4135-4154, 2018 Cited by PubMed: 29648813DOI: 10.1021/acs.jmedchem.8b00210 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.811 Å) |
Structure validation
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