4R4Z
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![BU of 4r4z by Molmil](/molmil-images/mine/4r4z) | Structure of PNGF-II in P21 space group | Descriptor: | PNGF-II | Authors: | Sun, G, Yu, X, Celimuge, Wang, L, Li, M, Gan, J, Qu, D, Ma, J, Chen, L. | Deposit date: | 2014-08-20 | Release date: | 2015-01-28 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Identification and
Characterization of a Novel Prokaryotic Peptide: N-glycosidase from
Elizabethkingia meningoseptica J.Biol.Chem., 2015
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4R4X
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![BU of 4r4x by Molmil](/molmil-images/mine/4r4x) | Structure of PNGF-II in C2 space group | Descriptor: | PNGF-II, ZINC ION | Authors: | Sun, G, Yu, X, Celimuge, Wang, L, Li, M, Gan, J, Qu, D, Ma, J, Chen, L. | Deposit date: | 2014-08-20 | Release date: | 2015-01-28 | Last modified: | 2023-12-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Identification and
Characterization of a Novel Prokaryotic Peptide: N-glycosidase from
Elizabethkingia meningoseptica J.Biol.Chem., 2015
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6M4P
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![BU of 6m4p by Molmil](/molmil-images/mine/6m4p) | Cytochrome P450 monooxygenase StvP2 substrate-bound structure | Descriptor: | 6-methoxy-streptovaricin C, Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Sun, G, Hu, C, Mei, Q, Luo, M, Chen, X, Li, Z, Liu, Y, Deng, Z, Zhang, Z, Sun, Y. | Deposit date: | 2020-03-08 | Release date: | 2020-08-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis. Nat Commun, 11, 2020
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6M4Q
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![BU of 6m4q by Molmil](/molmil-images/mine/6m4q) | Cytochrome P450 monooxygenase StvP2 substrate-free structure | Descriptor: | Cytochrome P450, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Sun, G, Hu, C, Mei, Q, Luo, M, Chen, X, Li, Z, Liu, Y, Deng, Z, Zhang, Z, Sun, Y. | Deposit date: | 2020-03-08 | Release date: | 2020-08-12 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (1.35 Å) | Cite: | Uncovering the cytochrome P450-catalyzed methylenedioxy bridge formation in streptovaricins biosynthesis. Nat Commun, 11, 2020
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5EFS
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![BU of 5efs by Molmil](/molmil-images/mine/5efs) | The crystal structure of human kynurenine aminotransferase II | Descriptor: | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | Authors: | Nematollahi, A, Sun, G, Kwan, A, Harrop, S.J, Hanrahan, J.R, Nadvi, N.A, Church, W.B. | Deposit date: | 2015-10-26 | Release date: | 2015-11-11 | Last modified: | 2024-03-06 | Method: | X-RAY DIFFRACTION (1.82503 Å) | Cite: | The crystal structure of human kynurenine aminotransferase II To Be Published
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5EUN
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![BU of 5eun by Molmil](/molmil-images/mine/5eun) | The Crystal Structure of Human Kynurenine Aminotransferase II, PLP-bound form, at 1.83 A | Descriptor: | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | Authors: | Nematollahi, A, Sun, G, Kwan, A, Jeffries, C.M, Harrop, S.J, Hanrahan, J.R, Nadvi, N.A, Church, W.B. | Deposit date: | 2015-11-18 | Release date: | 2015-12-16 | Last modified: | 2016-08-10 | Method: | X-RAY DIFFRACTION (1.825 Å) | Cite: | Structure of the PLP-Form of the Human Kynurenine Aminotransferase II in a Novel Spacegroup at 1.83 angstrom Resolution. Int J Mol Sci, 17, 2016
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3CIU
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![BU of 3ciu by Molmil](/molmil-images/mine/3ciu) | Site-Selective Glycosylation of Cysteine-93 beta on the Surface of Bovine Hemoglobin and its Application as a Novel Oxygen Therapeutic | Descriptor: | 5-(2,5-dioxopyrrolidin-1-yl)-N-[2-(2-{2-[(4-O-alpha-D-idopyranosyl-alpha-D-mannopyranosyl)oxy]ethoxy}ethoxy)ethyl]pentanamide, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | Authors: | Bhatt, V.S, Zhang, Y, Sun, G, Wang, P.G, Palmer, A.F. | Deposit date: | 2008-03-11 | Release date: | 2008-04-15 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (3.5 Å) | Cite: | Site-Selective Glycosylation of Cysteine-93 beta on the Surface of Bovine Hemoglobin and its Application as a Novel Oxygen Therapeutic To be Published
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1YQ4
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![BU of 1yq4 by Molmil](/molmil-images/mine/1yq4) | Avian respiratory complex ii with 3-nitropropionate and ubiquinone | Descriptor: | 1,2-Dioleoyl-sn-glycero-3-phosphoethanolamine, 3-NITROPROPANOIC ACID, Coenzyme Q10, ... | Authors: | Huang, L, Sun, G, Cobessi, D, Wang, A, Shen, J.T, Tung, E.Y, Anderson, V.E, Berry, E.A. | Deposit date: | 2005-02-01 | Release date: | 2005-12-20 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.33 Å) | Cite: | 3-Nitropropionic Acid Is a Suicide Inhibitor of Mitochondrial Respiration That, upon Oxidation by Complex II, Forms a Covalent Adduct with a Catalytic Base Arginine in the Active Site of the Enzyme J.Biol.Chem., 281, 2006
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2FBW
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![BU of 2fbw by Molmil](/molmil-images/mine/2fbw) | Avian respiratory complex II with carboxin bound | Descriptor: | (~{Z})-2-oxidanylbut-2-enedioic acid, 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE, AZIDE ION, ... | Authors: | Huang, L.S, Sun, G, Cobessi, D, Wang, A.C, Shen, J.T, Tung, E.Y, Anderson, V.E, Berry, E.A. | Deposit date: | 2005-12-10 | Release date: | 2005-12-20 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.06 Å) | Cite: | 3-nitropropionic acid is a suicide inhibitor of mitochondrial respiration that, upon oxidation by complex II, forms a covalent adduct with a catalytic base arginine in the active site of the enzyme. J.Biol.Chem., 281, 2006
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5TF5
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![BU of 5tf5 by Molmil](/molmil-images/mine/5tf5) | CRYSTAL STRUCTURE OF HUMAN KAT-2 IN COMPLEX WITH A REVERSIBLE INHIBITOR | Descriptor: | (2R)-2-(5,6-dichloro-1,3-dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-phenylpropanoic acid, Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | Authors: | Nematollahi, A, Sun, G, Church, W.B. | Deposit date: | 2016-09-24 | Release date: | 2016-10-05 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (1.807 Å) | Cite: | Crystal structure and mechanistic analysis of a novel human kynurenine aminotransferase-2 reversible inhibitor Med.Chem.Res., 2017
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6D0A
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![BU of 6d0a by Molmil](/molmil-images/mine/6d0a) | |
3K43
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![BU of 3k43 by Molmil](/molmil-images/mine/3k43) | Crystal structure of sCD-MPR mutant E19Q/K137M pH 6.5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, ACETATE ION, Cation-dependent mannose-6-phosphate receptor, ... | Authors: | Olson, L.J, Sun, G, Bohnsack, R.N, Peterson, F.C, Dahms, N.M, Kim, J.J.P. | Deposit date: | 2009-10-05 | Release date: | 2009-11-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor. Biochemistry, 49, 2010
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3K42
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![BU of 3k42 by Molmil](/molmil-images/mine/3k42) | Crystal structure of sCD-MPR mutant E19Q/K137M pH 7.0 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-dependent mannose-6-phosphate receptor, SN-GLYCEROL-1-PHOSPHATE, ... | Authors: | Olson, L.J, Sun, G, Bohnsack, R.N, Peterson, F.C, Dahms, N.M, Kim, J.J.P. | Deposit date: | 2009-10-05 | Release date: | 2009-11-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor. Biochemistry, 49, 2010
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3K41
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![BU of 3k41 by Molmil](/molmil-images/mine/3k41) | Crystal structure of sCD-MPR mutant E19Q/K137M bound to Man-6-P | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 6-O-phosphono-beta-D-mannopyranose, Cation-dependent mannose-6-phosphate receptor, ... | Authors: | Olson, L.J, Sun, G, Bohnsack, R.N, Peterson, F.C, Dahms, N.M, Kim, J.J.P. | Deposit date: | 2009-10-05 | Release date: | 2009-11-24 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Intermonomer interactions are essential for lysosomal enzyme binding by the cation-dependent mannose 6-phosphate receptor. Biochemistry, 49, 2010
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6DJW
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![BU of 6djw by Molmil](/molmil-images/mine/6djw) | Crystal Structure of pParkin (REP and RING2 deleted)-pUb-UbcH7 complex | Descriptor: | RBR-type E3 ubiquitin transferase,RBR-type E3 ubiquitin transferase, Ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ... | Authors: | Sauve, V, Sung, G, Trempe, J.F, Gehring, K. | Deposit date: | 2018-05-26 | Release date: | 2018-07-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (3.801 Å) | Cite: | Mechanism of parkin activation by phosphorylation. Nat. Struct. Mol. Biol., 25, 2018
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6DJX
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![BU of 6djx by Molmil](/molmil-images/mine/6djx) | Crystal Structure of pParkin-pUb-UbcH7 complex | Descriptor: | RBR-type E3 ubiquitin transferase,RBR-type E3 ubiquitin transferase, Ubiquitin, Ubiquitin-conjugating enzyme E2 L3, ... | Authors: | Sauve, V, Sung, G, Trempe, J.F, Gehring, K. | Deposit date: | 2018-05-27 | Release date: | 2018-07-04 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (4.801 Å) | Cite: | Mechanism of parkin activation by phosphorylation. Nat. Struct. Mol. Biol., 25, 2018
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2O1S
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![BU of 2o1s by Molmil](/molmil-images/mine/2o1s) | 1-deoxy-D-xylulose 5-phosphate synthase (DXS) from Escherichia coli | Descriptor: | 1-deoxy-D-xylulose-5-phosphate synthase, DIPHOSPHATE, MAGNESIUM ION, ... | Authors: | Xiang, S, Usunow, G, Lange, G, Busch, M, Tong, L. | Deposit date: | 2006-11-29 | Release date: | 2006-12-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Crystal Structure of 1-Deoxy-D-xylulose 5-Phosphate Synthase, a Crucial Enzyme for Isoprenoids Biosynthesis. J.Biol.Chem., 282, 2007
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2O1X
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![BU of 2o1x by Molmil](/molmil-images/mine/2o1x) | 1-deoxy-D-xylulose 5-phosphate synthase (DXS) from Deinococcus radiodurans | Descriptor: | 1-deoxy-D-xylulose-5-phosphate synthase, MAGNESIUM ION, THIAMINE DIPHOSPHATE | Authors: | Xiang, S, Usunow, G, Lange, G, Busch, M, Tong, L. | Deposit date: | 2006-11-29 | Release date: | 2006-12-26 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Crystal Structure of 1-Deoxy-D-xylulose 5-Phosphate Synthase, a Crucial Enzyme for Isoprenoids Biosynthesis. J.Biol.Chem., 282, 2007
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2WQY
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![BU of 2wqy by Molmil](/molmil-images/mine/2wqy) | Remodelling of carboxin binding to the Q-site of avian respiratory complex II | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, 2-METHYL-N-PHENYL-5,6-DIHYDRO-1,4-OXATHIINE-3-CARBOXAMIDE, AZIDE ION, ... | Authors: | Ruprecht, J, Iwata, S, Cecchini, G. | Deposit date: | 2009-08-27 | Release date: | 2010-08-25 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Remodelling of Carboxin Binding to the Q-Site of Avian Respiratory Complex II To be Published
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6PNX
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![BU of 6pnx by Molmil](/molmil-images/mine/6pnx) | |
8QXC
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![BU of 8qxc by Molmil](/molmil-images/mine/8qxc) | Crystal structure of antibody Fab MIL-3 with PenG-Lys | Descriptor: | (2R,4S)-2-[(1R)-2-[[(5S)-5-acetamido-6-oxidanyl-6-oxidanylidene-hexyl]amino]-2-oxidanylidene-1-(2-phenylethanoylamino)ethyl]-5,5-dimethyl-1,3-thiazolidine-4-carboxylic acid, Heavy chain of FAB MIL-3, Light chain of FAB MIL-3 | Authors: | Moynie, L, Naismith, J.H. | Deposit date: | 2023-10-24 | Release date: | 2024-07-31 | Last modified: | 2024-08-21 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Covalent penicillin-protein conjugates elicit anti-drug antibodies that are clonally and functionally restricted. Nat Commun, 15, 2024
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8HF8
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![BU of 8hf8 by Molmil](/molmil-images/mine/8hf8) | Human PPAR delta ligand binding domain in complex with a synthetic agonist V1 | Descriptor: | 2-[4-[[2,5-bis(oxidanylidene)-3-[4-(trifluoromethyl)phenyl]imidazolidin-1-yl]methyl]-2,6-dimethyl-phenoxy]-2-methyl-propanoic acid, Peroxisome proliferator-activated receptor delta, octyl beta-D-glucopyranoside | Authors: | Dai, L, Sun, H.B, Yuan, H.L, Feng, Z.Q. | Deposit date: | 2022-11-09 | Release date: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.11 Å) | Cite: | Discovery of the First Subnanomolar PPAR alpha / delta Dual Agonist for the Treatment of Cholestatic Liver Diseases. J.Med.Chem., 66, 2023
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1YQ3
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![BU of 1yq3 by Molmil](/molmil-images/mine/1yq3) | Avian respiratory complex ii with oxaloacetate and ubiquinone | Descriptor: | 1,2-dioleoyl-sn-glycero-3-phosphoethanolamine, Coenzyme Q10, (2Z,6E,10Z,14E,18E,22E,26Z)-isomer, ... | Authors: | Huang, L, Cobessi, D, Tung, E.Y, Berry, E.A. | Deposit date: | 2005-02-01 | Release date: | 2005-12-20 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | 3-Nitropropionic Acid Is a Suicide Inhibitor of Mitochondrial Respiration That, upon Oxidation by Complex II, Forms a Covalent Adduct with a Catalytic Base Arginine in the Active Site of the Enzyme J.Biol.Chem., 281, 2006
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1SIH
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![BU of 1sih by Molmil](/molmil-images/mine/1sih) | AGAO in covalent complex with the inhibitor MOBA ("4-(4-methylphenoxy)-2-butyn-1-amine") | Descriptor: | COPPER (II) ION, GLYCEROL, Phenylethylamine oxidase, ... | Authors: | Guss, J.M, Langley, D.B, Duff, A.P. | Deposit date: | 2004-02-29 | Release date: | 2004-09-07 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.73 Å) | Cite: | Differential Inhibition of Six Copper Amine Oxidases by a Family of 4-(Aryloxy)-2-butynamines: Evidence for a New Mode of Inactivation. Biochemistry, 43, 2004
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1SII
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![BU of 1sii by Molmil](/molmil-images/mine/1sii) | AGAO in covalent complex with the inhibitor NOBA ("4-(2-naphthyloxy)-2-butyn-1-amine") | Descriptor: | COPPER (II) ION, GLYCEROL, Phenylethylamine oxidase, ... | Authors: | Guss, J.M, Langley, D.B, Duff, A.P. | Deposit date: | 2004-02-29 | Release date: | 2004-09-07 | Last modified: | 2017-10-11 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | Differential Inhibition of Six Copper Amine Oxidases by a Family of 4-(Aryloxy)-2-butynamines: Evidence for a New Mode of Inactivation. Biochemistry, 43, 2004
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