8HF8

Human PPAR delta ligand binding domain in complex with a synthetic agonist V1

Summary for 8HF8

Entry DOI	10.2210/pdb8hf8/pdb
Descriptor	Peroxisome proliferator-activated receptor delta, 2-[4-[[2,5-bis(oxidanylidene)-3-[4-(trifluoromethyl)phenyl]imidazolidin-1-yl]methyl]-2,6-dimethyl-phenoxy]-2-methyl-propanoic acid, octyl beta-D-glucopyranoside, ... (4 entities in total)
Functional Keywords	complex, agonist, peroxisome proliferator-activated receptor, nuclear protein
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	66234.81
Authors	Dai, L.,Sun, H.B.,Yuan, H.L.,Feng, Z.Q. (deposition date: 2022-11-09, release date: 2023-09-06)
Primary citation	Feng, Z.,Xiang, J.,Sun, G.,Liu, H.,Wang, Y.,Liu, X.,Feng, J.,Xu, Q.,Wen, X.,Yuan, H.,Sun, H.,Dai, L. Discovery of the First Subnanomolar PPAR alpha / delta Dual Agonist for the Treatment of Cholestatic Liver Diseases. J.Med.Chem., 66:7331-7354, 2023 Cited by PubMed: 37243609 DOI: 10.1021/acs.jmedchem.2c02123 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.11 Å)

Structure validation