8HF8

Human PPAR delta ligand binding domain in complex with a synthetic agonist V1

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Peroxisome proliferator-activated receptor delta	polymer	282	32360.6	2	UniProt (Q03181) Pfam (PF00104)	Homo sapiens (human)	PPAR-delta,NUCI,Nuclear hormone receptor 1,NUC1,Nuclear receptor subfamily 1 group C member 2,Peroxisome proliferator-activated receptor beta,PPAR-beta
2	C, E (A, B)	2-[4-[[2,5-bis(oxidanylidene)-3-[4-(trifluoromethyl)phenyl]imidazolidin-1-yl]methyl]-2,6-dimethyl-phenoxy]-2-methyl-propanoic acid	non-polymer		464.4	2	Chemie (LOO)
3	D, F (A, B)	octyl beta-D-glucopyranoside	non-polymer		292.4	2	Chemie (BOG)
4	G, H (A, B)	water	water		18.0	240	Chemie (HOH)

Sequence modifications

A, B: 209 - 477 (UniProt: Q03181)

PDB	External Database	Details
Met 196	-	initiating methionine
His 197	-	expression tag
His 198	-	expression tag
His 199	-	expression tag
His 200	-	expression tag
His 201	-	expression tag
His 202	-	expression tag
Leu 203	-	expression tag
Val 204	-	expression tag
Pro 205	-	expression tag
Arg 206	-	expression tag
Gly 207	-	expression tag
Ser 208	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	2
	Total formula weight	64721.2
Non-Polymers*	Number of molecules	4
	Total formula weight	1513.6
All*	Total formula weight	66234.8

*Water molecules are not included.