4ZWJ
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![BU of 4zwj by Molmil](/molmil-images/mine/4zwj) | Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser | Descriptor: | Chimera protein of human Rhodopsin, mouse S-arrestin, and T4 Endolysin | Authors: | Kang, Y, Zhou, X.E, Gao, X, He, Y, Liu, W, Ishchenko, A, Barty, A, White, T.A, Yefanov, O, Han, G.W, Xu, Q, de Waal, P.W, Ke, J, Tan, M.H.E, Zhang, C, Moeller, A, West, G.M, Pascal, B, Eps, N.V, Caro, L.N, Vishnivetskiy, S.A, Lee, R.J, Suino-Powell, K.M, Gu, X, Pal, K, Ma, J, Zhi, X, Boutet, S, Williams, G.J, Messerschmidt, M, Gati, C, Zatsepin, N.A, Wang, D, James, D, Basu, S, Roy-Chowdhury, S, Conrad, C, Coe, J, Liu, H, Lisova, S, Kupitz, C, Grotjohann, I, Fromme, R, Jiang, Y, Tan, M, Yang, H, Li, J, Wang, M, Zheng, Z, Li, D, Howe, N, Zhao, Y, Standfuss, J, Diederichs, K, Dong, Y, Potter, C.S, Carragher, B, Caffrey, M, Jiang, H, Chapman, H.N, Spence, J.C.H, Fromme, P, Weierstall, U, Ernst, O.P, Katritch, V, Gurevich, V.V, Griffin, P.R, Hubbell, W.L, Stevens, R.C, Cherezov, V, Melcher, K, Xu, H.E, GPCR Network (GPCR) | Deposit date: | 2015-05-19 | Release date: | 2015-07-29 | Last modified: | 2023-09-27 | Method: | X-RAY DIFFRACTION (3.302 Å) | Cite: | Crystal structure of rhodopsin bound to arrestin by femtosecond X-ray laser. Nature, 523, 2015
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3QWY
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![BU of 3qwy by Molmil](/molmil-images/mine/3qwy) | CED-2 | Descriptor: | Cell death abnormality protein 2, GLYCEROL, SULFATE ION | Authors: | Kang, Y, Sun, J, Liu, Y, Sun, D, Hu, Y, Liu, Y.F. | Deposit date: | 2011-02-28 | Release date: | 2011-06-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.52 Å) | Cite: | Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem.Biophys.Res.Commun., 410, 2011
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6CMO
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![BU of 6cmo by Molmil](/molmil-images/mine/6cmo) | Rhodopsin-Gi complex | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Fab Heavy chain, Fab light chain, ... | Authors: | Kang, Y, Kuybeda, O, de Waal, P.W, Mukherjee, S, Van Eps, N, Dutka, P, Zhou, X.E, Bartesaghi, A, Erramilli, S, Morizumi, T, Gu, X, Yin, Y, Liu, P, Jiang, Y, Meng, X, Zhao, G, Melcher, K, Earnst, O.P, Kossiakoff, A.A, Subramaniam, S, Xu, H.E. | Deposit date: | 2018-03-05 | Release date: | 2018-06-20 | Last modified: | 2020-07-29 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Cryo-EM structure of human rhodopsin bound to an inhibitory G protein. Nature, 558, 2018
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3QWX
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![BU of 3qwx by Molmil](/molmil-images/mine/3qwx) | CED-2 1-174 | Descriptor: | Cell death abnormality protein 2, SULFATE ION | Authors: | Kang, Y, Sun, J, Liu, Y. | Deposit date: | 2011-02-28 | Release date: | 2011-06-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Crystal structure of the cell corpse engulfment protein CED-2 in Caenorhabditis elegans. Biochem.Biophys.Res.Commun., 410, 2011
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3RN4
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![BU of 3rn4 by Molmil](/molmil-images/mine/3rn4) | Crystal structure of iron-substituted Sod2 from Saccharomyces cerevisiae | Descriptor: | FE (III) ION, Superoxide dismutase [Mn], mitochondrial | Authors: | Kang, Y, He, Y.-X, Cheng, W, Zhou, C.-Z, Li, W.-F. | Deposit date: | 2011-04-21 | Release date: | 2011-11-23 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (1.79 Å) | Cite: | Structures of native and Fe-substituted SOD2 from Saccharomyces cerevisiae Acta Crystallogr.,Sect.F, 67, 2011
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7KNW
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![BU of 7knw by Molmil](/molmil-images/mine/7knw) | Crystal structure of SND1 in complex with C-26-A2 | Descriptor: | 5-chloro-2-methoxy-N-([1,2,4]triazolo[1,5-a]pyridin-8-yl)benzene-1-sulfonamide, GLYCEROL, Staphylococcal nuclease domain-containing protein 1 | Authors: | Kang, Y. | Deposit date: | 2020-11-06 | Release date: | 2021-12-08 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.65 Å) | Cite: | Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. Nat Cancer, 3, 2022
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7KNX
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![BU of 7knx by Molmil](/molmil-images/mine/7knx) | Crystal structure of SND1 in complex with C-26-A6 | Descriptor: | 5-chloro-2-methoxy-N-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-8-yl)benzene-1-sulfonamide, GLYCEROL, Staphylococcal nuclease domain-containing protein 1, ... | Authors: | Kang, Y. | Deposit date: | 2020-11-06 | Release date: | 2021-12-08 | Last modified: | 2024-05-22 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis. Nat Cancer, 3, 2022
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7CU3
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![BU of 7cu3 by Molmil](/molmil-images/mine/7cu3) | Structure of mammalian NALCN-FAM155A complex at 2.65 angstrom | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CHOLESTEROL, Sodium leak channel non-selective protein, ... | Authors: | Chen, L, Kang, Y. | Deposit date: | 2020-08-20 | Release date: | 2020-11-18 | Last modified: | 2021-06-02 | Method: | ELECTRON MICROSCOPY (2.65 Å) | Cite: | Structure of voltage-modulated sodium-selective NALCN-FAM155A channel complex. Nat Commun, 11, 2020
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8J1N
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![BU of 8j1n by Molmil](/molmil-images/mine/8j1n) | Structure of human UCP1 in the DNP-bound state | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2,4-DINITROPHENOL, CARDIOLIPIN, ... | Authors: | Chen, L, Kang, Y. | Deposit date: | 2023-04-13 | Release date: | 2023-06-21 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.51 Å) | Cite: | Structural basis for the binding of DNP and purine nucleotides onto UCP1. Nature, 620, 2023
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7W7G
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![BU of 7w7g by Molmil](/molmil-images/mine/7w7g) | |
8HBW
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![BU of 8hbw by Molmil](/molmil-images/mine/8hbw) | Structure of human UCP1 in the ATP-bound state | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, ADENOSINE-5'-TRIPHOSPHATE, CARDIOLIPIN, ... | Authors: | Chen, L, Kang, Y. | Deposit date: | 2022-10-31 | Release date: | 2023-06-21 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.57 Å) | Cite: | Structural basis for the binding of DNP and purine nucleotides onto UCP1. Nature, 620, 2023
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8HBV
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![BU of 8hbv by Molmil](/molmil-images/mine/8hbv) | Structure of human UCP1 in the nucleotide-free state | Descriptor: | 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CARDIOLIPIN, Mitochondrial brown fat uncoupling protein 1, ... | Authors: | Chen, L, Kang, Y. | Deposit date: | 2022-10-31 | Release date: | 2023-06-21 | Last modified: | 2023-08-30 | Method: | ELECTRON MICROSCOPY (2.51 Å) | Cite: | Structural basis for the binding of DNP and purine nucleotides onto UCP1. Nature, 620, 2023
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6JT2
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![BU of 6jt2 by Molmil](/molmil-images/mine/6jt2) | Structure of human soluble guanylate cyclase in the NO activated state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | Authors: | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | Deposit date: | 2019-04-08 | Release date: | 2019-09-04 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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6JT1
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![BU of 6jt1 by Molmil](/molmil-images/mine/6jt1) | Structure of human soluble guanylate cyclase in the heme oxidised state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | Deposit date: | 2019-04-08 | Release date: | 2019-08-28 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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6JT0
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![BU of 6jt0 by Molmil](/molmil-images/mine/6jt0) | Structure of human soluble guanylate cyclase in the unliganded state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Chen, L, Kang, Y, Liu, R, Wu, J.-X. | Deposit date: | 2019-04-08 | Release date: | 2019-08-28 | Last modified: | 2024-03-27 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structural insights into the mechanism of human soluble guanylate cyclase. Nature, 574, 2019
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6OMM
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![BU of 6omm by Molmil](/molmil-images/mine/6omm) | Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi | Descriptor: | CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Zhuang, Y, Liu, H, de Waal, P.W, Zhou, X.E, Wang, L, Meng, X, Zhao, G, Kang, Y, Melcher, K, Xu, H.E, Zhang, C. | Deposit date: | 2019-04-19 | Release date: | 2020-02-26 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Structure of formylpeptide receptor 2-Gicomplex reveals insights into ligand recognition and signaling. Nat Commun, 11, 2020
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6NBH
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![BU of 6nbh by Molmil](/molmil-images/mine/6nbh) | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein | Descriptor: | CHOLESTEROL, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhao, L.-H, Ma, S, Sutkeviciute, I, Shen, D.-D, Zhou, X.E, de Waal, P.P, Li, C.-Y, Kang, Y, Clark, L.J, Jean-Alphonse, F.G, White, A.D, Xiao, K, Yang, D, Jiang, Y, Watanabe, T, Gardella, T.J, Melcher, K, Wang, M.-W, Vilardaga, J.-P, Xu, H.E, Zhang, Y. | Deposit date: | 2018-12-07 | Release date: | 2019-04-17 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3.5 Å) | Cite: | Structure and dynamics of the active human parathyroid hormone receptor-1. Science, 364, 2019
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6NBF
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![BU of 6nbf by Molmil](/molmil-images/mine/6nbf) | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein | Descriptor: | CHOLESTEROL, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhao, L.-H, Ma, S, Sutkeviciute, I, Shen, D.-D, Zhou, X.E, de Waal, P.P, Li, C.-Y, Kang, Y, Clark, L.J, Jean-Alphonse, F.G, White, A.D, Xiao, K, Yang, D, Jiang, Y, Watanabe, T, Gardella, T.J, Melcher, K, Wang, M.-W, Vilardaga, J.-P, Xu, H.E, Zhang, Y. | Deposit date: | 2018-12-07 | Release date: | 2019-04-17 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (3 Å) | Cite: | Structure and dynamics of the active human parathyroid hormone receptor-1. Science, 364, 2019
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6NBI
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![BU of 6nbi by Molmil](/molmil-images/mine/6nbi) | Cryo-EM structure of parathyroid hormone receptor type 1 in complex with a long-acting parathyroid hormone analog and G protein | Descriptor: | CHOLESTEROL, Gs protein alpha subunit, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | Authors: | Zhao, L.-H, Ma, S, Sutkeviciute, I, Shen, D.-D, Zhou, X.E, de Waal, P.P, Li, C.-Y, Kang, Y, Clark, L.J, Jean-Alphonse, F.G, White, A.D, Xiao, K, Yang, D, Jiang, Y, Watanabe, T, Gardella, T.J, Melcher, K, Wang, M.-W, Vilardaga, J.-P, Xu, H.E, Zhang, Y. | Deposit date: | 2018-12-07 | Release date: | 2019-04-17 | Last modified: | 2019-12-18 | Method: | ELECTRON MICROSCOPY (4 Å) | Cite: | Structure and dynamics of the active human parathyroid hormone receptor-1. Science, 364, 2019
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7D9R
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![BU of 7d9r by Molmil](/molmil-images/mine/7d9r) | Structure of huamn soluble guanylate cyclase in the riociguat and NO-bound state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.7 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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7D9U
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![BU of 7d9u by Molmil](/molmil-images/mine/7d9u) | Structure of human soluble guanylate cyclase in the cinciguat-bound activated state | Descriptor: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, ... | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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7D9S
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![BU of 7d9s by Molmil](/molmil-images/mine/7d9s) | Structure of huamn soluble guanylate cyclase in the YC1 and NO-bound state | Descriptor: | Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1, MAGNESIUM ION, ... | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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7D9T
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![BU of 7d9t by Molmil](/molmil-images/mine/7d9t) | Structure of human soluble guanylate cyclase in the cinciguat-bound inactive state | Descriptor: | 4-({(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)benzyl]oxy}phenyl)ethyl]amino}methyl)benzoic acid, Guanylate cyclase soluble subunit alpha-1, Guanylate cyclase soluble subunit beta-1 | Authors: | Chen, L, Liu, R, Kang, Y. | Deposit date: | 2020-10-14 | Release date: | 2021-08-11 | Last modified: | 2024-05-29 | Method: | ELECTRON MICROSCOPY (4.1 Å) | Cite: | Activation mechanism of human soluble guanylate cyclase by stimulators and activators. Nat Commun, 12, 2021
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4QMG
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![BU of 4qmg by Molmil](/molmil-images/mine/4qmg) | The Structure of MTDH-SND1 Complex Reveals Novel Cancer-Promoting Interactions | Descriptor: | CESIUM ION, GLYCEROL, Protein LYRIC, ... | Authors: | Guo, F, Stanevich, V, Wan, L, Satyshur, K, Kang, Y, Xing, Y. | Deposit date: | 2014-06-16 | Release date: | 2014-10-08 | Method: | X-RAY DIFFRACTION (2.701 Å) | Cite: | Structural Insights into the Tumor-Promoting Function of the MTDH-SND1 Complex. Cell Rep, 8, 2014
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7SQO
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![BU of 7sqo by Molmil](/molmil-images/mine/7sqo) | Structure of the orexin-2 receptor(OX2R) bound to TAK-925, Gi and scFv16 | Descriptor: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha-1, ... | Authors: | McGrath, A.P, Kang, Y, Flinspach, M. | Deposit date: | 2021-11-05 | Release date: | 2022-05-25 | Last modified: | 2022-07-06 | Method: | ELECTRON MICROSCOPY (3.17 Å) | Cite: | Molecular mechanism of the wake-promoting agent TAK-925. Nat Commun, 13, 2022
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