7KNX

Crystal structure of SND1 in complex with C-26-A6

Summary for 7KNX

• Entry DOI: 10.2210/pdb7knx/pdb
• Descriptor: Staphylococcal nuclease domain-containing protein 1, TYROSINE, 5-chloro-2-methoxy-N-(2-methyl[1,2,4]triazolo[1,5-a]pyridin-8-yl)benzene-1-sulfonamide, ... (5 entities in total)
• Functional Keywords: inhibitor, endonuclease, hydrolase, hydrolase-inhibitor complex, hydrolase/inhibitor
• Biological source: Homo sapiens (Human)
• Total number of polymer chains: 4
• Total formula weight: 148872.45

Authors

Kang, Y. (deposition date: 2020-11-06, release date: 2021-12-08, Last modification date: 2022-02-16)

• Primary citation: Shen, M.,Wei, Y.,Kim, H.,Wan, L.,Jiang, Y.Z.,Hang, X.,Raba, M.,Remiszewski, S.,Rowicki, M.,Wu, C.G.,Wu, S.,Zhang, L.,Lu, X.,Yuan, M.,Smith, H.A.,Zheng, A.,Bertino, J.,Jin, J.F.,Xing, Y.,Shao, Z.M.,Kang, Y.; Small-molecule inhibitors that disrupt the MTDH-SND1 complex suppress breast cancer progression and metastasis.; Nat Cancer, 3:43-59, 2022; PubMed: 35121987; DOI: 10.1038/s43018-021-00279-5

Experimental method

X-RAY DIFFRACTION (2.7 Å)