6K0Z
| Substrate bound state of Staphylococcus Aureus AldH | Descriptor: | 1,2-ETHANEDIOL, Aldehyde dehydrogenase, GLYCEROL | Authors: | Zhang, Z, Tao, X. | Deposit date: | 2019-05-08 | Release date: | 2020-05-20 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2.4967258 Å) | Cite: | Structural Insight into the Substrate Gating Mechanism by Staphylococcus aureus Aldehyde Dehydrogenase CCS Chemistry, 2, 2020
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5YA5
| CRYSTAL STRUCTURE OF c-MET IN COMPLEX WITH NOVEL INHIBITOR | Descriptor: | 2-[3-(4-methoxybenzyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]-1H-indole, Hepatocyte growth factor receptor | Authors: | Liu, Q, Xu, Y. | Deposit date: | 2017-08-30 | Release date: | 2018-07-04 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (1.89 Å) | Cite: | Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors Eur J Med Chem, 143, 2018
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6J9J
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7WAA
| Crystal structure of MCR-1-S treated by AgNO3 | Descriptor: | Probable phosphatidylethanolamine transferase Mcr-1, SILVER ION | Authors: | Zhang, Q, Wang, M, Sun, H. | Deposit date: | 2021-12-13 | Release date: | 2022-03-16 | Method: | X-RAY DIFFRACTION (1.58 Å) | Cite: | Re-sensitization of mcr carrying multidrug resistant bacteria to colistin by silver. Proc.Natl.Acad.Sci.USA, 119, 2022
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7XR4
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7XR6
| Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with WAY-213613 | Descriptor: | (2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid, 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, CHOLESTEROL HEMISUCCINATE, ... | Authors: | Zhao, Y, Zhang, Z. | Deposit date: | 2022-05-09 | Release date: | 2022-06-22 | Last modified: | 2024-07-03 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Structural basis of ligand binding modes of human EAAT2. Nat Commun, 13, 2022
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8FYG
| Crystal structure of Hyaluronate lyase A from Cutibacterium acnes | Descriptor: | 1,2-ETHANEDIOL, GLYCEROL, Hyaluronate lyase | Authors: | Katiki, M, McNally, R, Chatterjee, A, Hajam, I.A, Liu, G.Y, Murali, R. | Deposit date: | 2023-01-26 | Release date: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.05 Å) | Cite: | Functional divergence of a bacterial enzyme promotes healthy or acneic skin. Nat Commun, 14, 2023
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8FNX
| Crystal structure of Hyaluronate lyase B from Cutibacterium acnes | Descriptor: | GLYCEROL, Hyaluronate lyase, PHOSPHATE ION | Authors: | Katiki, M, McNally, R, Chatterjee, A, Hajam, I.A, Liu, G.Y, Murali, R. | Deposit date: | 2022-12-28 | Release date: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Functional divergence of a bacterial enzyme promotes healthy or acneic skin. Nat Commun, 14, 2023
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8G0O
| Crystal structure of Y281F mutant of Hyaluronate lyase B from Cutibacterium acnes | Descriptor: | Hyaluronate lyase | Authors: | Katiki, M, McNally, R, Chatterjee, A, Hajam, I.A, Liu, G.Y, Murali, R. | Deposit date: | 2023-02-01 | Release date: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Functional divergence of a bacterial enzyme promotes healthy or acneic skin. Nat Commun, 14, 2023
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7WKX
| IL-17A in complex with the humanized antibody HB0017 | Descriptor: | ACETIC ACID, Heavy chain of HB0017 Fab, Interleukin-17A, ... | Authors: | Xu, J, Zhu, X, He, Y. | Deposit date: | 2022-01-12 | Release date: | 2022-03-23 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.81 Å) | Cite: | Structural and functional insights into a novel pre-clinical-stage antibody targeting IL-17A for treatment of autoimmune diseases. Int.J.Biol.Macromol., 202, 2022
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8HT7
| The N-terminal region of Cdc6 specifically recognizes human DNA G-quadruplex | Descriptor: | DNA (5'-D(*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*AP*GP*GP*GP*TP*TP*TP*GP*GP*G)-3'), GLN-ALA-GLN-ALA-THR-ILE-SER-PHE-PRO-LYS-ARG-LYS-LEU-SER-TRP | Authors: | Liu, C, Zhu, G, Geng, Y, Xu, N. | Deposit date: | 2022-12-20 | Release date: | 2023-12-27 | Last modified: | 2024-05-22 | Method: | SOLUTION NMR | Cite: | The N-terminal region of Cdc6 specifically recognizes human DNA G-quadruplex. Int.J.Biol.Macromol., 260, 2024
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7YFK
| The structure of human pregnane X receptor in complex with an SRC-1 coactivator peptide and a limonoid compound, nomilin | Descriptor: | Nomilin, Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 | Authors: | Xia, Y, Yao, D, Huang, C, Cao, Y. | Deposit date: | 2022-07-08 | Release date: | 2023-06-14 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions. Nat Commun, 14, 2023
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7WN8
| Crystal structure of antibody (BC31M5) binds to CD47 | Descriptor: | BC31M5 Fab Heavy chain, BC31M5 Fab Light chain, Leukocyte surface antigen CD47, ... | Authors: | Li, Y, Wang, W, Sui, J, Zhang, S. | Deposit date: | 2022-01-17 | Release date: | 2023-01-25 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | A pH-dependent anti-CD47 antibody that selectively targets solid tumors and improves therapeutic efficacy and safety. J Hematol Oncol, 16, 2023
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1PHD
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1PHC
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1PHG
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1PHE
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1PHF
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7W1Q
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1OXA
| CYTOCHROME P450 (DONOR:O2 OXIDOREDUCTASE) | Descriptor: | 6-DEOXYERYTHRONOLIDE B, CYTOCHROME P450 ERYF, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Cupp-Vickery, J.R, Poulos, T.L. | Deposit date: | 1995-07-14 | Release date: | 1995-12-07 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structure of cytochrome P450eryF involved in erythromycin biosynthesis. Nat.Struct.Biol., 2, 1995
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7YJP
| Crystal structure of MCR-1 treated by AuCl | Descriptor: | GOLD ION, Probable phosphatidylethanolamine transferase Mcr-1 | Authors: | Zhang, Q, Wang, M, Sun, H. | Deposit date: | 2022-07-20 | Release date: | 2023-02-01 | Last modified: | 2023-03-15 | Method: | X-RAY DIFFRACTION (1.88 Å) | Cite: | Gold drugs as colistin adjuvants in the fight against MCR-1 producing bacteria. J.Biol.Inorg.Chem., 28, 2023
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7YJS
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7YJR
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7YJQ
| Crystal structure of MCR-1-S treated by auranofin | Descriptor: | GOLD ION, Probable phosphatidylethanolamine transferase Mcr-1 | Authors: | Zhang, Q, Sun, H, Wang, M. | Deposit date: | 2022-07-20 | Release date: | 2023-02-01 | Last modified: | 2023-03-15 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Gold drugs as colistin adjuvants in the fight against MCR-1 producing bacteria. J.Biol.Inorg.Chem., 28, 2023
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7YJT
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