7XR6

Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with WAY-213613

Summary for 7XR6

• Entry DOI: 10.2210/pdb7xr6/pdb
• EMDB information: 33408
• Descriptor: Excitatory amino acid transporter 2, (2S)-2-azanyl-4-[[4-[2-bromanyl-4,5-bis(fluoranyl)phenoxy]phenyl]amino]-4-oxidanylidene-butanoic acid, CHOLESTEROL HEMISUCCINATE, ... (5 entities in total)
• Functional Keywords: glutamate transport, transport protein
• Biological source: Homo sapiens (human)
• Total number of polymer chains: 3
• Total formula weight: 213950.44

Authors

Zhao, Y.,Zhang, Z. (deposition date: 2022-05-09, release date: 2022-06-22)

• Primary citation: Zhang, Z.,Chen, H.,Geng, Z.,Yu, Z.,Li, H.,Dong, Y.,Zhang, H.,Huang, Z.,Jiang, J.,Zhao, Y.; Structural basis of ligand binding modes of human EAAT2.; Nat Commun, 13:3329-3329, 2022; PubMed: 35680945; DOI: 10.1038/s41467-022-31031-x

Experimental method

ELECTRON MICROSCOPY (3.4 Å)