Summary Structural details Experimental details Functional details Sequence Neighbor History Downloads

7XR6

Structure of human excitatory amino acid transporter 2 (EAAT2) in complex with WAY-213613

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0005313	molecular_function	L-glutamate transmembrane transporter activity
A	0005314	molecular_function	high-affinity L-glutamate transmembrane transporter activity
A	0005515	molecular_function	protein binding
A	0005886	cellular_component	plasma membrane
A	0006750	biological_process	glutathione biosynthetic process
A	0006811	biological_process	monoatomic ion transport
A	0006836	biological_process	neurotransmitter transport
A	0006865	biological_process	amino acid transport
A	0007268	biological_process	chemical synaptic transmission
A	0007399	biological_process	nervous system development
A	0007632	biological_process	visual behavior
A	0008509	molecular_function	monoatomic anion transmembrane transporter activity
A	0009410	biological_process	response to xenobiotic stimulus
A	0009416	biological_process	response to light stimulus
A	0009611	biological_process	response to wounding
A	0009986	cellular_component	cell surface
A	0015175	molecular_function	neutral L-amino acid transmembrane transporter activity
A	0015293	molecular_function	symporter activity
A	0015501	molecular_function	glutamate:sodium symporter activity
A	0015804	biological_process	neutral amino acid transport
A	0015813	biological_process	L-glutamate transmembrane transport
A	0016020	cellular_component	membrane
A	0021537	biological_process	telencephalon development
A	0030424	cellular_component	axon
A	0030534	biological_process	adult behavior
A	0030673	cellular_component	axolemma
A	0031982	cellular_component	vesicle
A	0033229	molecular_function	cysteine transmembrane transporter activity
A	0035264	biological_process	multicellular organism growth
A	0042734	cellular_component	presynaptic membrane
A	0043200	biological_process	response to amino acid
A	0044297	cellular_component	cell body
A	0044306	cellular_component	neuron projection terminus
A	0045121	cellular_component	membrane raft
A	0045202	cellular_component	synapse
A	0046326	biological_process	positive regulation of D-glucose import
A	0046872	molecular_function	metal ion binding
A	0070207	biological_process	protein homotrimerization
A	0070633	biological_process	transepithelial transport
A	0070778	biological_process	L-aspartate transmembrane transport
A	0070779	biological_process	D-aspartate import across plasma membrane
A	0071314	biological_process	cellular response to cocaine
A	0097449	cellular_component	astrocyte projection
A	0098656	biological_process	monoatomic anion transmembrane transport
A	0098657	biological_process	import into cell
A	0098712	biological_process	L-glutamate import across plasma membrane
A	0098796	cellular_component	membrane protein complex
A	0098810	biological_process	neurotransmitter reuptake
A	0098978	cellular_component	glutamatergic synapse
A	0140009	biological_process	L-aspartate import across plasma membrane
A	0150104	biological_process	transport across blood-brain barrier
A	1903712	biological_process	cysteine transmembrane transport
B	0005313	molecular_function	L-glutamate transmembrane transporter activity
B	0005314	molecular_function	high-affinity L-glutamate transmembrane transporter activity
B	0005515	molecular_function	protein binding
B	0005886	cellular_component	plasma membrane
B	0006750	biological_process	glutathione biosynthetic process
B	0006811	biological_process	monoatomic ion transport
B	0006836	biological_process	neurotransmitter transport
B	0006865	biological_process	amino acid transport
B	0007268	biological_process	chemical synaptic transmission
B	0007399	biological_process	nervous system development
B	0007632	biological_process	visual behavior
B	0008509	molecular_function	monoatomic anion transmembrane transporter activity
B	0009410	biological_process	response to xenobiotic stimulus
B	0009416	biological_process	response to light stimulus
B	0009611	biological_process	response to wounding
B	0009986	cellular_component	cell surface
B	0015175	molecular_function	neutral L-amino acid transmembrane transporter activity
B	0015293	molecular_function	symporter activity
B	0015501	molecular_function	glutamate:sodium symporter activity
B	0015804	biological_process	neutral amino acid transport
B	0015813	biological_process	L-glutamate transmembrane transport
B	0016020	cellular_component	membrane
B	0021537	biological_process	telencephalon development
B	0030424	cellular_component	axon
B	0030534	biological_process	adult behavior
B	0030673	cellular_component	axolemma
B	0031982	cellular_component	vesicle
B	0033229	molecular_function	cysteine transmembrane transporter activity
B	0035264	biological_process	multicellular organism growth
B	0042734	cellular_component	presynaptic membrane
B	0043200	biological_process	response to amino acid
B	0044297	cellular_component	cell body
B	0044306	cellular_component	neuron projection terminus
B	0045121	cellular_component	membrane raft
B	0045202	cellular_component	synapse
B	0046326	biological_process	positive regulation of D-glucose import
B	0046872	molecular_function	metal ion binding
B	0070207	biological_process	protein homotrimerization
B	0070633	biological_process	transepithelial transport
B	0070778	biological_process	L-aspartate transmembrane transport
B	0070779	biological_process	D-aspartate import across plasma membrane
B	0071314	biological_process	cellular response to cocaine
B	0097449	cellular_component	astrocyte projection
B	0098656	biological_process	monoatomic anion transmembrane transport
B	0098657	biological_process	import into cell
B	0098712	biological_process	L-glutamate import across plasma membrane
B	0098796	cellular_component	membrane protein complex
B	0098810	biological_process	neurotransmitter reuptake
B	0098978	cellular_component	glutamatergic synapse
B	0140009	biological_process	L-aspartate import across plasma membrane
B	0150104	biological_process	transport across blood-brain barrier
B	1903712	biological_process	cysteine transmembrane transport
C	0005313	molecular_function	L-glutamate transmembrane transporter activity
C	0005314	molecular_function	high-affinity L-glutamate transmembrane transporter activity
C	0005515	molecular_function	protein binding
C	0005886	cellular_component	plasma membrane
C	0006750	biological_process	glutathione biosynthetic process
C	0006811	biological_process	monoatomic ion transport
C	0006836	biological_process	neurotransmitter transport
C	0006865	biological_process	amino acid transport
C	0007268	biological_process	chemical synaptic transmission
C	0007399	biological_process	nervous system development
C	0007632	biological_process	visual behavior
C	0008509	molecular_function	monoatomic anion transmembrane transporter activity
C	0009410	biological_process	response to xenobiotic stimulus
C	0009416	biological_process	response to light stimulus
C	0009611	biological_process	response to wounding
C	0009986	cellular_component	cell surface
C	0015175	molecular_function	neutral L-amino acid transmembrane transporter activity
C	0015293	molecular_function	symporter activity
C	0015501	molecular_function	glutamate:sodium symporter activity
C	0015804	biological_process	neutral amino acid transport
C	0015813	biological_process	L-glutamate transmembrane transport
C	0016020	cellular_component	membrane
C	0021537	biological_process	telencephalon development
C	0030424	cellular_component	axon
C	0030534	biological_process	adult behavior
C	0030673	cellular_component	axolemma
C	0031982	cellular_component	vesicle
C	0033229	molecular_function	cysteine transmembrane transporter activity
C	0035264	biological_process	multicellular organism growth
C	0042734	cellular_component	presynaptic membrane
C	0043200	biological_process	response to amino acid
C	0044297	cellular_component	cell body
C	0044306	cellular_component	neuron projection terminus
C	0045121	cellular_component	membrane raft
C	0045202	cellular_component	synapse
C	0046326	biological_process	positive regulation of D-glucose import
C	0046872	molecular_function	metal ion binding
C	0070207	biological_process	protein homotrimerization
C	0070633	biological_process	transepithelial transport
C	0070778	biological_process	L-aspartate transmembrane transport
C	0070779	biological_process	D-aspartate import across plasma membrane
C	0071314	biological_process	cellular response to cocaine
C	0097449	cellular_component	astrocyte projection
C	0098656	biological_process	monoatomic anion transmembrane transport
C	0098657	biological_process	import into cell
C	0098712	biological_process	L-glutamate import across plasma membrane
C	0098796	cellular_component	membrane protein complex
C	0098810	biological_process	neurotransmitter reuptake
C	0098978	cellular_component	glutamatergic synapse
C	0140009	biological_process	L-aspartate import across plasma membrane
C	0150104	biological_process	transport across blood-brain barrier
C	1903712	biological_process	cysteine transmembrane transport

Functional Information from PROSITE/UniProt

site_id	PS00713
Number of Residues	15
Details	NA_DICARBOXYL_SYMP_1 Sodium:dicarboxylate symporter family signature 1. P.GDiLMrMLKMLIlP

Chain	Residue	Details
A	PRO81-PRO95

site_id	PS00714
Number of Residues	24
Details	NA_DICARBOXYL_SYMP_2 Sodium:dicarboxylate symporter family signature 2. PvGaTiNMDGTaLYeaVaaIFIAQ

Chain	Residue	Details
A	PRO391-GLN414

Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	180
Details	Transmembrane: {"description":"Helical","evidences":[{"evidenceCode":"ECO:0000255"}]}

Chain

Residue

Details

site_id	SWS_FT_FI2
Number of Residues	198
Details	Topological domain: {"description":"Extracellular","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI3
Number of Residues	93
Details	Topological domain: {"description":"Cytoplasmic","evidences":[{"evidenceCode":"ECO:0000305"}]}

Chain

Residue

Details

site_id	SWS_FT_FI4
Number of Residues	69
Details	Transmembrane: {"description":"Helical; Name=4","evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI5
Number of Residues	81
Details	Transmembrane: {"description":"Helical; Name=5","evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI6
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=6","evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI7
Number of Residues	189
Details	Intramembrane: {"description":"Discontinuously helical","evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI8
Number of Residues	78
Details	Transmembrane: {"description":"Helical; Name=7","evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI9
Number of Residues	63
Details	Transmembrane: {"description":"Helical; Name=8","evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI10
Number of Residues	27
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"P43003","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI11
Number of Residues	12
Details	Binding site: {"evidences":[{"source":"UniProtKB","id":"O59010","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI12
Number of Residues	3
Details	Modified residue: {"description":"Phosphoserine","evidences":[{"source":"UniProtKB","id":"P43006","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

site_id	SWS_FT_FI13
Number of Residues	3
Details	Lipidation: {"description":"S-palmitoyl cysteine","evidences":[{"source":"UniProtKB","id":"P43006","evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

		Sequence (fasta)
		PDBx/mmCIF
		PDBML format (no-atom)
		PDB format (full)
		Validation report (PDF)