7WKX

IL-17A in complex with the humanized antibody HB0017

Summary for 7WKX

• Entry DOI: 10.2210/pdb7wkx/pdb
• Descriptor: Heavy chain of HB0017 Fab, Light chain of HB0017 Fab, Interleukin-17A, ... (6 entities in total)
• Functional Keywords: hb0017, il17a, monoclonal antibody, complex, cytokine
• Biological source: Homo sapiens; More
• Total number of polymer chains: 6
• Total formula weight: 130062.77

Authors

Xu, J.,Zhu, X.,He, Y. (deposition date: 2022-01-12, release date: 2022-03-23, Last modification date: 2023-11-29)

• Primary citation: Xu, J.G.,Jia, H.,Chen, S.,Xu, J.,Zhan, Y.,Yu, H.,Wang, W.,Kang, X.,Cui, X.,Feng, Y.,Chen, X.,Xu, W.,Pan, X.,Wei, X.,Li, H.,Wang, Y.,Xia, S.,Liu, X.,Yang, L.,He, Y.,Zhu, X.; Structural and functional insights into a novel pre-clinical-stage antibody targeting IL-17A for treatment of autoimmune diseases.; Int.J.Biol.Macromol., 202:529-538, 2022; PubMed: 35066019; DOI: 10.1016/j.ijbiomac.2022.01.119

Experimental method

X-RAY DIFFRACTION (2.81 Å)