7WKX

IL-17A in complex with the humanized antibody HB0017

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B	Heavy chain of HB0017 Fab	polymer	217	23154.7	2		Homo sapiens
2	C, D	Light chain of HB0017 Fab	polymer	219	23964.6	2		Homo sapiens
3	E, F	Interleukin-17A	polymer	151	17427.7	2	UniProt (Q16552) Pfam (PF06083) In PDB	Homo sapiens (human)	IL-17,IL-17A,Cytotoxic T-lymphocyte-associated antigen 8,CTLA-8
4	A, B, C, E, F	MALONIC ACID	non-polymer		104.1	7	Chemie (MLA)
5	A, B, C, D	ACETIC ACID	non-polymer		60.1	4	Chemie (ACY)
6		water	water		18.0	37	Chemie (HOH)

Sequence modifications

E, F: 20 - 155 (UniProt: Q16552)

PDB	External Database	Details
Met 5	-	initiating methionine
Gly 6	-	expression tag
His 7	-	expression tag
His 8	-	expression tag
His 9	-	expression tag
His 10	-	expression tag
His 11	-	expression tag
His 12	-	expression tag
Glu 13	-	expression tag
Asn 14	-	expression tag
Leu 15	-	expression tag
Tyr 16	-	expression tag
Phe 17	-	expression tag
Gln 18	-	expression tag
Gly 19	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	6
	Total formula weight	129094.1
Non-Polymers*	Number of molecules	11
	Total formula weight	968.6
All*	Total formula weight	130062.8

*Water molecules are not included.