5YA5

CRYSTAL STRUCTURE OF c-MET IN COMPLEX WITH NOVEL INHIBITOR

Summary for 5YA5

DescriptorHepatocyte growth factor receptor, 2-[3-(4-methoxybenzyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]-1H-indole (3 entities in total)
Functional Keywordsc-met inhibitor, transferase-inhibitor complex, transferase/inhibitor
Biological sourceHomo sapiens (Human)
Total number of polymer chains1
Total molecular weight36395.01
Authors
Liu, Q.,Xu, Y. (deposition date: 2017-08-30, release date: 2018-07-04)
Primary citation
Yuan, H.,Liu, Q.,Zhang, L.,Hu, S.,Chen, T.,Li, H.,Chen, Y.,Xu, Y.,Lu, T.
Discovery, optimization and biological evaluation for novel c-Met kinase inhibitors
Eur J Med Chem, 143:491-502, 2018
PubMed: 29202410 (PDB entries with the same primary citation)
DOI: 10.1016/j.ejmech.2017.11.073
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (1.89 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.24540.8%5.6%11.4%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution