5YA5
CRYSTAL STRUCTURE OF c-MET IN COMPLEX WITH NOVEL INHIBITOR
Entity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A | Hepatocyte growth factor receptor | polymer | 319 | 36033.6 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (Human) | HGF receptor,HGF/SF receptor,Proto-oncogene c-Met,Scatter factor receptor,SF receptor,Tyrosine-protein kinase Met |
2 | A | 2-[3-(4-methoxybenzyl)[1,2,4]triazolo[3,4-b][1,3,4]thiadiazol-6-yl]-1H-indole | non-polymer | 361.4 | 1 | Chemie (6TD) | |||
3 | water | water | 18.0 | 108 | Chemie (HOH) |
Sequence modifications
A: 1038 - 1346 (UniProt: P08581)
PDB | External Database | Details |
---|---|---|
Met 1028 | - | initiating methionine |
Gly 1029 | - | expression tag |
Ser 1030 | - | expression tag |
Ser 1031 | - | expression tag |
His 1032 | - | expression tag |
His 1033 | - | expression tag |
His 1034 | - | expression tag |
His 1035 | - | expression tag |
His 1036 | - | expression tag |
His 1037 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 1 |
Total formula weight | 36033.6 | |
Non-Polymers* | Number of molecules | 1 |
Total formula weight | 361.4 | |
All* | Total formula weight | 36395.0 |