7YFK
The structure of human pregnane X receptor in complex with an SRC-1 coactivator peptide and a limonoid compound, nomilin
Replaces: 7CHGSummary for 7YFK
Entry DOI | 10.2210/pdb7yfk/pdb |
Descriptor | Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1, Nomilin (3 entities in total) |
Functional Keywords | complex, activator, transcription, drug binding, nuclear receptor |
Biological source | Homo sapiens (human) More |
Total number of polymer chains | 2 |
Total formula weight | 78143.82 |
Authors | |
Primary citation | Fan, S.,Yan, Y.,Xia, Y.,Zhou, Z.,Luo, L.,Zhu, M.,Han, Y.,Yao, D.,Zhang, L.,Fang, M.,Peng, L.,Yu, J.,Liu, Y.,Gao, X.,Guan, H.,Li, H.,Wang, C.,Wu, X.,Zhu, H.,Cao, Y.,Huang, C. Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions. Nat Commun, 14:3368-3368, 2023 Cited by PubMed: 37291126DOI: 10.1038/s41467-023-39118-9 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.1 Å) |
Structure validation
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