7YFK
The structure of human pregnane X receptor in complex with an SRC-1 coactivator peptide and a limonoid compound, nomilin
Replaces: 7CHGEntity
Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
1 | A, B | Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 | polymer | 340 | 38557.3 | 2 | UniProt (O75469) UniProt (Q15788) Pfam (PF00104) Pfam (PF08832) In PDB | Homo sapiens (human) | Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Pregnane X receptor,Steroid and xenobiotic receptor,SXR,NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1 |
2 | A, B | Nomilin | non-polymer | 514.6 | 2 | Chemie (G3L) | |||
3 | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
A, B: 130 - 434 (UniProt: O75469)
A, B: 441 - 465 (UniProt: Q15788)
PDB | External Database | Details |
---|---|---|
Met 129 | - | initiating methionine |
Ser 435 | - | linker |
Ser 436 | - | linker |
Ser 437 | - | linker |
Gly 438 | - | linker |
Gly 439 | - | linker |
Thr 440 | - | linker |
PDB | External Database | Details |
---|---|---|
Ala 466 | - | expression tag |
Ala 467 | - | expression tag |
Ala 468 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
Polymers | Number of chains | 2 |
Total formula weight | 77114.7 | |
Non-Polymers* | Number of molecules | 2 |
Total formula weight | 1029.1 | |
All* | Total formula weight | 78143.8 |