7YFK
The structure of human pregnane X receptor in complex with an SRC-1 coactivator peptide and a limonoid compound, nomilin
Replaces: 7CHGEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 | polymer | 340 | 38557.3 | 2 | UniProt (O75469) UniProt (Q15788) Pfam (PF00104) Pfam (PF08832) | Homo sapiens (human) | Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Pregnane X receptor,Steroid and xenobiotic receptor,SXR,NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1 |
| 2 | C, D (A, B) | Nomilin | non-polymer | 514.6 | 2 | Chemie (G3L) PubChem (25749378) PubChem (25749379) PubChem (46783795) PubChem (53393453) PubChem (72320) PubChem (6710776) PubChem (326240) PubChem (92258988) PubChem (92258989) PubChem (92258990) PubChem (92258987) PubChem (99722449) PubChem (99722450) PubChem (99722451) PubChem (99722452) PubChem (5320186) PubChem (124746184) PubChem (124746181) PubChem (124746183) PubChem (125459989) PubChem (122130875) PubChem (122173177) PubChem (12313416) PubChem (124746182) PubChem (146156358) PubChem (162942378) PubChem (162942371) PubChem (137706495) PubChem (159199874) PubChem (162942372) PubChem (162942373) PubChem (162942374) PubChem (162942375) PubChem (162942376) PubChem (162942377) PubChem (162942379) PubChem (162942380) PubChem (162942381) PubChem (162942382) PubChem (171666765) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
A, B: 130 - 434 (UniProt: O75469)
A, B: 441 - 465 (UniProt: Q15788)
| PDB | External Database | Details |
|---|---|---|
| Met 129 | - | initiating methionine |
| Ser 435 | - | linker |
| Ser 436 | - | linker |
| Ser 437 | - | linker |
| Gly 438 | - | linker |
| Gly 439 | - | linker |
| Thr 440 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 466 | - | expression tag |
| Ala 467 | - | expression tag |
| Ala 468 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77114.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1029.1 | |
| All* | Total formula weight | 78143.8 |
