7YFK
The structure of human pregnane X receptor in complex with an SRC-1 coactivator peptide and a limonoid compound, nomilin
Replaces: 7CHGEntity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, B (A, B) | Nuclear receptor subfamily 1 group I member 2,Nuclear receptor coactivator 1 | polymer | 340 | 38557.3 | 2 | UniProt (O75469) UniProt (Q15788) Pfam (PF00104) Pfam (PF08832) | Homo sapiens (human) | Orphan nuclear receptor PAR1,Orphan nuclear receptor PXR,Pregnane X receptor,Steroid and xenobiotic receptor,SXR,NCoA-1,Class E basic helix-loop-helix protein 74,bHLHe74,Protein Hin-2,RIP160,Renal carcinoma antigen NY-REN-52,Steroid receptor coactivator 1,SRC-1 |
| 2 | C, D (A, B) | Nomilin | non-polymer | 514.6 | 2 | Chemie (G3L) | |||
| 3 | E, F (A, B) | water | water | 18.0 | 187 | Chemie (HOH) |
Sequence modifications
A, B: 130 - 434 (UniProt: O75469)
A, B: 441 - 465 (UniProt: Q15788)
| PDB | External Database | Details |
|---|---|---|
| Met 129 | - | initiating methionine |
| Ser 435 | - | linker |
| Ser 436 | - | linker |
| Ser 437 | - | linker |
| Gly 438 | - | linker |
| Gly 439 | - | linker |
| Thr 440 | - | linker |
| PDB | External Database | Details |
|---|---|---|
| Ala 466 | - | expression tag |
| Ala 467 | - | expression tag |
| Ala 468 | - | expression tag |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 2 |
| Total formula weight | 77114.7 | |
| Non-Polymers* | Number of molecules | 2 |
| Total formula weight | 1029.1 | |
| All* | Total formula weight | 78143.8 |
