8SRH
| Cryo-EM structure of TRPM2 chanzyme (E1114A) in the presence of Magnesium and ADP-ribose, open state | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, MAGNESIUM ION, ... | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (3.79 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRF
| Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium, ADP-ribose, Adenosine monophosphate, and Ribose-5-phosphate, closed state | Descriptor: | 5-O-phosphono-beta-D-ribofuranose, ADENOSINE MONOPHOSPHATE, ADENOSINE-5-DIPHOSPHORIBOSE, ... | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.52 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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8SRJ
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8SRE
| Cryo-EM structure of TRPM2 chanzyme in the presence of Magnesium and ADP-ribose, closed state | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, CHOLESTEROL, MAGNESIUM ION, ... | Authors: | Huang, Y, Kumar, S, Lu, W, Du, J. | Deposit date: | 2023-05-05 | Release date: | 2024-05-15 | Method: | ELECTRON MICROSCOPY (2.52 Å) | Cite: | Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution To Be Published
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3FIP
| Crystal structure of Usher PapC translocation pore | Descriptor: | Outer membrane usher protein papC | Authors: | Huang, Y, Deisenhofer, J. | Deposit date: | 2008-12-12 | Release date: | 2009-09-08 | Last modified: | 2024-02-21 | Method: | X-RAY DIFFRACTION (3.154 Å) | Cite: | Insights into pilus assembly and secretion from the structure and functional characterization of usher PapC. Proc.Natl.Acad.Sci.USA, 106, 2009
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8GTC
| Cryo-EM model of the marine siphophage vB_DshS-R4C baseplate-tail complex | Descriptor: | Distal tail protein, Hub protein, Major tail protein, ... | Authors: | Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N. | Deposit date: | 2022-09-08 | Release date: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (4.5 Å) | Cite: | Structure and proposed DNA delivery mechanism of a marine roseophage. Nat Commun, 14, 2023
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8GTB
| Cryo-EM structure of the marine siphophage vB_DshS-R4C tail tube protein | Descriptor: | Major tail protein | Authors: | Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N. | Deposit date: | 2022-09-08 | Release date: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (3.43 Å) | Cite: | Structure and proposed DNA delivery mechanism of a marine roseophage. Nat Commun, 14, 2023
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8GTF
| Cryo-EM model of the marine siphophage vB_DshS-R4C stopper-terminator complex | Descriptor: | Head-to-tail joining protein, Major tail protein, Terminator protein | Authors: | Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N. | Deposit date: | 2022-09-08 | Release date: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (6.6 Å) | Cite: | Structure and proposed DNA delivery mechanism of a marine roseophage. Nat Commun, 14, 2023
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8GTD
| Cryo-EM model of the marine siphophage vB_DshS-R4C portal-adaptor complex | Descriptor: | Head-to-tail joining protein, Portal protein | Authors: | Huang, Y, Sun, H, Wei, S, Zheng, Q, Li, S, Zhang, R, Xia, N. | Deposit date: | 2022-09-08 | Release date: | 2023-07-12 | Method: | ELECTRON MICROSCOPY (4.7 Å) | Cite: | Structure and proposed DNA delivery mechanism of a marine roseophage. Nat Commun, 14, 2023
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1I4O
| CRYSTAL STRUCTURE OF THE XIAP/CASPASE-7 COMPLEX | Descriptor: | BACULOVIRAL IAP REPEAT-CONTAINING PROTEIN 4, CASPASE-7 | Authors: | Huang, Y, Park, Y.C, Rich, R.L, Segal, D, Myszka, D.G, Wu, H. | Deposit date: | 2001-02-22 | Release date: | 2001-03-21 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structural basis of caspase inhibition by XIAP: differential roles of the linker versus the BIR domain. Cell(Cambridge,Mass.), 104, 2001
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3MJ0
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5WQA
| Crystal structure of PDE4D catalytic domain complexed with Selaginpulvilins K | Descriptor: | 1-[2-(4-hydroxyphenyl)ethynyl]-9,9-bis(4-methoxyphenyl)-7-oxidanyl-fluorene-2-carbaldehyde, MAGNESIUM ION, ZINC ION, ... | Authors: | Huang, Y, Zhang, T, Zheng, X, Yin, S, Luo, H.B. | Deposit date: | 2016-11-24 | Release date: | 2017-02-22 | Last modified: | 2023-11-08 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | The discovery, complex crystal structure, and recognition mechanism of a novel natural PDE4 inhibitor from Selaginella pulvinata Biochem. Pharmacol., 130, 2017
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2GFA
| double tudor domain complex structure | Descriptor: | Jumonji domain-containing protein 2A, peptide | Authors: | Huang, Y, Fang, J, Bedford, M.T, Zhang, Y, Xu, R.M. | Deposit date: | 2006-03-21 | Release date: | 2006-05-02 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A Science, 312, 2006
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2IJG
| Crystal Structure of cryptochrome 3 from Arabidopsis thaliana | Descriptor: | 5,10-METHENYL-6,7,8-TRIHYDROFOLIC ACID, Cryptochrome DASH, chloroplast/mitochondrial, ... | Authors: | Huang, Y, Deisenhofer, J. | Deposit date: | 2006-09-29 | Release date: | 2006-11-28 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Crystal structure of cryptochrome 3 from Arabidopsis thaliana and its implications for photolyase activity Proc.Natl.Acad.Sci.Usa, 103, 2006
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6A6L
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7CFF
| Structure of the thermostabilized transmembrane domain of the bacterial CNNM/CorC family Mg2+ transporter in complex with Mg2+ | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Hemolysin, ... | Authors: | Huang, Y, Jin, F, Hattori, M. | Deposit date: | 2020-06-25 | Release date: | 2021-02-24 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Structural basis for the Mg 2+ recognition and regulation of the CorC Mg 2+ transporter. Sci Adv, 7, 2021
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7CFH
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7CFI
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7CFG
| Structure of the transmembrane domain of the bacterial CNNM/CorC family Mg2+ transporter in complex with Mg2+ | Descriptor: | (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Hemolysin, MAGNESIUM ION, ... | Authors: | Huang, Y, Jin, F, Hattori, M. | Deposit date: | 2020-06-25 | Release date: | 2021-02-24 | Last modified: | 2024-03-27 | Method: | X-RAY DIFFRACTION (3.2 Å) | Cite: | Structural basis for the Mg 2+ recognition and regulation of the CorC Mg 2+ transporter. Sci Adv, 7, 2021
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6KBB
| Role of the DEF/Y motif of Swc5 in histone H2A.Z deposition | Descriptor: | Histone H2A type 1-D, Histone H2B type 2-E, SWR1-complex protein 5 | Authors: | Huang, Y, Zhou, Z. | Deposit date: | 2019-06-24 | Release date: | 2020-01-29 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.365 Å) | Cite: | Role of a DEF/Y motif in histone H2A-H2B recognition and nucleosome editing. Proc.Natl.Acad.Sci.USA, 117, 2020
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7CFK
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7CWF
| Crystal structure of PDE8A catalytic domain in complex with 2c | Descriptor: | 9-[[4-[2,2-bis(fluoranyl)ethoxy]pyridin-2-yl]methyl]-2-chloranyl-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | Authors: | Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B. | Deposit date: | 2020-08-28 | Release date: | 2021-09-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. J.Med.Chem., 63, 2020
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7CWG
| Crystal structure of PDE8A catalytic domain in complex with 3a | Descriptor: | 9-[(1~{S})-1-[4-[2,2-bis(fluoranyl)ethoxy]pyridin-2-yl]ethyl]-2-chloranyl-purin-6-amine, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | Authors: | Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B. | Deposit date: | 2020-08-28 | Release date: | 2021-09-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. J.Med.Chem., 63, 2020
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7CWA
| Crystal structure of PDE8A catalytic domain in complex with clofarabine | Descriptor: | 2-CHLORO-9-(2-DEOXY-2-FLUORO-B -D-ARABINOFURANOSYL)-9H-PURIN-6-AMINE, High affinity cAMP-specific and IBMX-insensitive 3',5'-cyclic phosphodiesterase 8A, MAGNESIUM ION, ... | Authors: | Huang, Y, Wu, X.-N, Zhou, Q, Wu, Y, Luo, H.-B. | Deposit date: | 2020-08-27 | Release date: | 2021-09-01 | Last modified: | 2023-11-29 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Rational Design of 2-Chloroadenine Derivatives as Highly Selective Phosphodiesterase 8A Inhibitors. J.Med.Chem., 63, 2020
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7YL2
| Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004 | Descriptor: | Bromodomain-containing protein 4, GLYCEROL, N-(1-ethyl-2-oxidanylidene-3H-indol-5-yl)cyclohexanesulfonamide, ... | Authors: | Huang, Y, Wei, A, Dong, R, Xu, H, Zhang, C, Chen, Z, Li, J, Wu, X, Zhang, Y, Xu, Y. | Deposit date: | 2022-07-25 | Release date: | 2023-07-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (1.62 Å) | Cite: | Crystal Structure of the first bromodomain of human BRD4 in complex with the inhibitor Y07004 To Be Published
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