7WI0
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![BU of 7wi0 by Molmil](/molmil-images/mine/7wi0) | SARS-CoV-2 Omicron variant spike in complex with three human neutralizing antibodies | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IG c1437_light_IGLV1-40_IGLJ1, IG c934_light_IGKV1-5_IGKJ1, ... | Authors: | Zheng, Q, Li, S, Sun, H, Zheng, Z, Wang, S. | Deposit date: | 2022-01-01 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (3.82 Å) | Cite: | Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron. Cell Rep, 39, 2022
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7WHZ
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![BU of 7whz by Molmil](/molmil-images/mine/7whz) | SARS-CoV-2 spike protein in complex with three human neutralizing antibodies | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, IG c1437_light_IGLV1-40_IGLJ1, IG c934_light_IGKV1-5_IGKJ1, ... | Authors: | Zheng, Q, Li, S, Sun, H, Zheng, Z, Wang, S. | Deposit date: | 2022-01-01 | Release date: | 2022-06-22 | Method: | ELECTRON MICROSCOPY (3.42 Å) | Cite: | Three SARS-CoV-2 antibodies provide broad and synergistic neutralization against variants of concern, including Omicron. Cell Rep, 39, 2022
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8JUE
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![BU of 8jue by Molmil](/molmil-images/mine/8jue) | Crystal structure of glutaminase C in complex with compound 11 | Descriptor: | 2-(3-phenoxyphenyl)-N-[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]ethanamide, Glutaminase kidney isoform, mitochondrial | Authors: | Wang, X, Hanyu, S, Tingting, D. | Deposit date: | 2023-06-26 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.39 Å) | Cite: | Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. Acs Med.Chem.Lett., 14, 2023
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8JUB
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![BU of 8jub by Molmil](/molmil-images/mine/8jub) | Crystal structure of glutaminase C in complex with compound 27 | Descriptor: | 3-[2-oxidanylidene-2-[[5-[[(3R)-1-pyridazin-3-ylpyrrolidin-3-yl]amino]-1,3,4-thiadiazol-2-yl]amino]ethyl]benzoic acid, Glutaminase kidney isoform, mitochondrial | Authors: | Wang, X, Hanyu, S, Tingting, D. | Deposit date: | 2023-06-26 | Release date: | 2023-10-11 | Last modified: | 2023-11-01 | Method: | X-RAY DIFFRACTION (2.01 Å) | Cite: | Targeting the Subpocket Enables the Discovery of Thiadiazole-Pyridazine Derivatives as Glutaminase C Inhibitors. Acs Med.Chem.Lett., 14, 2023
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6IET
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![BU of 6iet by Molmil](/molmil-images/mine/6iet) | The crystal structure of TRIM66 PHD-Bromo domain | Descriptor: | Tripartite motif-containing protein 66, ZINC ION | Authors: | Chen, J. | Deposit date: | 2018-09-17 | Release date: | 2019-09-18 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.101 Å) | Cite: | TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells. Nat Commun, 10, 2019
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8HLL
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![BU of 8hll by Molmil](/molmil-images/mine/8hll) | Crystal structure of p53/BCL2 fusion complex (complex 1) | Descriptor: | Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION | Authors: | Wei, H, Guo, M, Wang, H, Chen, Y. | Deposit date: | 2022-11-30 | Release date: | 2023-07-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.62 Å) | Cite: | Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
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8HLM
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![BU of 8hlm by Molmil](/molmil-images/mine/8hlm) | Crystal structure of p53/BCL2 fusion complex (complex 2) | Descriptor: | Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION | Authors: | Guo, M, Wang, H, Wei, H, Chen, Y. | Deposit date: | 2022-11-30 | Release date: | 2023-07-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.522 Å) | Cite: | Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
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8HLN
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![BU of 8hln by Molmil](/molmil-images/mine/8hln) | Crystal structure of p53/BCL2 fusion complex(complex3) | Descriptor: | Apoptosis regulator Bcl-2, Cellular tumor antigen p53, ZINC ION | Authors: | Guo, M, Wei, H, Wang, H, Chen, Y. | Deposit date: | 2022-11-30 | Release date: | 2023-07-26 | Last modified: | 2024-05-29 | Method: | X-RAY DIFFRACTION (2.354 Å) | Cite: | Structures of p53/BCL-2 complex suggest a mechanism for p53 to antagonize BCL-2 activity. Nat Commun, 14, 2023
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6IEU
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![BU of 6ieu by Molmil](/molmil-images/mine/6ieu) | |
6LY5
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![BU of 6ly5 by Molmil](/molmil-images/mine/6ly5) | Organization and energy transfer in a huge diatom PSI-FCPI supercomplex | Descriptor: | (3S,3'R,5R,6S,7cis)-7',8'-didehydro-5,6-dihydro-5,6-epoxy-beta,beta-carotene-3,3'-diol, (3S,3'S,5R,5'R,6S,6'R,8'R)-3,5'-dihydroxy-8-oxo-6',7'-didehydro-5,5',6,6',7,8-hexahydro-5,6-epoxy-beta,beta-caroten-3'- yl acetate, 1,2-DI-O-ACYL-3-O-[6-DEOXY-6-SULFO-ALPHA-D-GLUCOPYRANOSYL]-SN-GLYCEROL, ... | Authors: | Xiong, P, Caizhe, X. | Deposit date: | 2020-02-13 | Release date: | 2020-10-21 | Method: | ELECTRON MICROSCOPY (2.38 Å) | Cite: | Structural basis for energy transfer in a huge diatom PSI-FCPI supercomplex. Nat Commun, 11, 2020
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1BIO
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![BU of 1bio by Molmil](/molmil-images/mine/1bio) | HUMAN COMPLEMENT FACTOR D IN COMPLEX WITH ISATOIC ANHYDRIDE INHIBITOR | Descriptor: | COMPLEMENT FACTOR D, GLYCEROL, ISATOIC ANHYDRIDE | Authors: | Jing, H, Babu, Y.S, Moore, D, Kilpatrick, J.M, Liu, X.-Y, Volanakis, J.E, Narayana, S.V.L. | Deposit date: | 1998-06-18 | Release date: | 1999-06-22 | Last modified: | 2023-08-02 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | Structures of native and complexed complement factor D: implications of the atypical His57 conformation and self-inhibitory loop in the regulation of specific serine protease activity. J.Mol.Biol., 282, 1998
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8WG7
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![BU of 8wg7 by Molmil](/molmil-images/mine/8wg7) | Cryo-EM structures of peptide free and Gs-coupled GLP-1R | Descriptor: | Glucagon-like peptide 1 receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | Deposit date: | 2023-09-20 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.54 Å) | Cite: | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins. Cell Discov, 10, 2024
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8WG8
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![BU of 8wg8 by Molmil](/molmil-images/mine/8wg8) | Cryo-EM structures of peptide free and Gs-coupled GCGR | Descriptor: | Glucagon receptor, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | Authors: | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | Deposit date: | 2023-09-20 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.71 Å) | Cite: | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins. Cell Discov, 10, 2024
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6N34
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![BU of 6n34 by Molmil](/molmil-images/mine/6n34) | Crystal structure of the BTB domain of Human NS1-BP | Descriptor: | Influenza virus NS1A-binding protein | Authors: | Zhang, K, Shang, G, Padavannil, A, Fontoura, B, Chook, Y.M. | Deposit date: | 2018-11-14 | Release date: | 2018-12-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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6N3H
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![BU of 6n3h by Molmil](/molmil-images/mine/6n3h) | Crystal structure of Kelch domain of the human NS1 binding protein | Descriptor: | Influenza virus NS1A-binding protein | Authors: | Zhang, K, Shang, G, Padavannil, A, Fontoura, B.M.A, Chook, Y.M. | Deposit date: | 2018-11-15 | Release date: | 2018-12-12 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural-functional interactions of NS1-BP protein with the splicing and mRNA export machineries for viral and host gene expression. Proc. Natl. Acad. Sci. U.S.A., 115, 2018
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1DST
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![BU of 1dst by Molmil](/molmil-images/mine/1dst) | |
8WA3
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![BU of 8wa3 by Molmil](/molmil-images/mine/8wa3) | Cryo-EM structure of peptide free and Gs-coupled GIPR | Descriptor: | Gastric inhibitory polypeptide receptor,Fusion protein, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1,O-antigen polymerase, ... | Authors: | Cong, Z.T, Zhao, F.H, Li, Y, Luo, G, Zhou, Q.T, Yang, D.H, Wang, M.W. | Deposit date: | 2023-09-06 | Release date: | 2024-03-06 | Method: | ELECTRON MICROSCOPY (2.86 Å) | Cite: | Molecular features of the ligand-free GLP-1R, GCGR and GIPR in complex with G s proteins. Cell Discov, 10, 2024
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3HYF
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![BU of 3hyf by Molmil](/molmil-images/mine/3hyf) | Crystal structure of HIV-1 RNase H p15 with engineered E. coli loop and active site inhibitor | Descriptor: | 2-(3,4-dichlorobenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid, ACETATE ION, GLYCEROL, ... | Authors: | Lansdon, E.B, Kirschberg, T.A. | Deposit date: | 2009-06-22 | Release date: | 2009-10-20 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.7 Å) | Cite: | RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. J.Med.Chem., 52, 2009
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7WQ4
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![BU of 7wq4 by Molmil](/molmil-images/mine/7wq4) | Galanin-bound galanin receptor 2 in complex with Gq | Descriptor: | CHOLESTEROL, Engineered Guanine nucleotide-binding protein G(q) subunit alpha, Galanin, ... | Authors: | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | Deposit date: | 2022-01-24 | Release date: | 2022-04-20 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (2.6 Å) | Cite: | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022
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7WQ3
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![BU of 7wq3 by Molmil](/molmil-images/mine/7wq3) | Galanin-bound galanin receptor 1 in complex with Gi | Descriptor: | CHOLESTEROL, Galanin, Galanin receptor type 1, ... | Authors: | Duan, J, Shen, D.D, Xu, H.E, Zhang, Y, Jiang, Y. | Deposit date: | 2022-01-24 | Release date: | 2022-04-20 | Last modified: | 2022-10-19 | Method: | ELECTRON MICROSCOPY (2.7 Å) | Cite: | Molecular basis for allosteric agonism and G protein subtype selectivity of galanin receptors Nat Commun, 13, 2022
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1FDP
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![BU of 1fdp by Molmil](/molmil-images/mine/1fdp) | PROENZYME OF HUMAN COMPLEMENT FACTOR D, RECOMBINANT PROFACTOR D | Descriptor: | PROENZYME OF COMPLEMENT FACTOR D | Authors: | Jing, H, Macon, K.J, Moore, D, Delucas, L.J, Volanakis, J.E, Narayana, S.V.L. | Deposit date: | 1998-12-03 | Release date: | 1999-12-03 | Last modified: | 2023-08-09 | Method: | X-RAY DIFFRACTION (2.1 Å) | Cite: | Structural basis of profactor D activation: from a highly flexible zymogen to a novel self-inhibited serine protease, complement factor D. Embo J., 18, 1999
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5YKO
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![BU of 5yko by Molmil](/molmil-images/mine/5yko) | |
5YKN
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![BU of 5ykn by Molmil](/molmil-images/mine/5ykn) | crystal structure of Arabidopsis thaliana JMJ14 catalytic domain | Descriptor: | NICKEL (II) ION, Probable lysine-specific demethylase JMJ14, ZINC ION | Authors: | Yang, Z, Du, J. | Deposit date: | 2017-10-15 | Release date: | 2017-12-27 | Last modified: | 2023-11-22 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Structure of the Arabidopsis JMJ14-H3K4me3 Complex Provides Insight into the Substrate Specificity of KDM5 Subfamily Histone Demethylases. Plant Cell, 30, 2018
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6O1F
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![BU of 6o1f by Molmil](/molmil-images/mine/6o1f) | |
3MJK
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![BU of 3mjk by Molmil](/molmil-images/mine/3mjk) | Structure of a growth factor precursor | Descriptor: | Platelet-derived growth factor subunit A | Authors: | Liu, H, He, X. | Deposit date: | 2010-04-12 | Release date: | 2010-06-16 | Last modified: | 2023-09-06 | Method: | X-RAY DIFFRACTION (2.4 Å) | Cite: | Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex. Proc.Natl.Acad.Sci.USA, 107, 2010
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