3HYF

Crystal structure of HIV-1 RNase H p15 with engineered E. coli loop and active site inhibitor

Summary for 3HYF

Entry DOI	10.2210/pdb3hyf/pdb
Descriptor	Reverse transcriptase/RNaseH, MANGANESE (II) ION, ACETATE ION, ... (6 entities in total)
Functional Keywords	rnase h, hiv-1, hydrolase, di-valent metal nucleic acid cleavage mechanism, di-valent metal coordination, aspartyl protease, dna integration, dna recombination, endonuclease, multifunctional enzyme, nuclease, nucleotidyltransferase, protease, rna-directed dna polymerase, transferase, magnesium, metal-binding
Biological source	Human immunodeficiency virus 1 More
Total number of polymer chains	1
Total formula weight	17589.68
Authors	Lansdon, E.B.,Kirschberg, T.A. (deposition date: 2009-06-22, release date: 2009-10-20, Last modification date: 2024-03-13)
Primary citation	Kirschberg, T.A.,Balakrishnan, M.,Squires, N.H.,Barnes, T.,Brendza, K.M.,Chen, X.,Eisenberg, E.J.,Jin, W.,Kutty, N.,Leavitt, S.,Liclican, A.,Liu, Q.,Liu, X.,Mak, J.,Perry, J.K.,Wang, M.,Watkins, W.J.,Lansdon, E.B. RNase H active site inhibitors of human immunodeficiency virus type 1 reverse transcriptase: design, biochemical activity, and structural information. J.Med.Chem., 52:5781-5784, 2009 Cited by PubMed: 19791799 DOI: 10.1021/jm900597q PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.7 Å)

Structure validation