3HYF
Crystal structure of HIV-1 RNase H p15 with engineered E. coli loop and active site inhibitor
Functional Information from GO Data
Functional Information from PDB Data
| site_id | AC1 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE MN A 601 |
| Chain | Residue |
| A | ASP443 |
| A | GLU478 |
| A | ASP498 |
| A | MN602 |
| A | ON1701 |
| site_id | AC2 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE MN A 602 |
| Chain | Residue |
| A | HOH604 |
| A | ON1701 |
| A | ASP443 |
| A | ASP549 |
| A | MN601 |
| A | HOH603 |
| site_id | AC3 |
| Number of Residues | 4 |
| Details | BINDING SITE FOR RESIDUE ACT A 650 |
| Chain | Residue |
| A | HOH166 |
| A | TYR441 |
| A | GLY544 |
| A | GLN547 |
| site_id | AC4 |
| Number of Residues | 6 |
| Details | BINDING SITE FOR RESIDUE GOL A 698 |
| Chain | Residue |
| A | HOH10 |
| A | HOH33 |
| A | HOH180 |
| A | HOH184 |
| A | ARG461 |
| A | GLY490 |
| site_id | AC5 |
| Number of Residues | 5 |
| Details | BINDING SITE FOR RESIDUE GOL A 699 |
| Chain | Residue |
| A | HOH182 |
| A | ARG448 |
| A | THR473 |
| A | ASN474 |
| A | GLN475 |
| site_id | AC6 |
| Number of Residues | 16 |
| Details | BINDING SITE FOR RESIDUE ON1 A 701 |
| Chain | Residue |
| A | HOH4 |
| A | HOH7 |
| A | HOH15 |
| A | HOH41 |
| A | ASP443 |
| A | GLU478 |
| A | ASP498 |
| A | GLN500 |
| A | ALA538 |
| A | HIS539 |
| A | ASP549 |
| A | ARG557 |
| A | MN601 |
| A | MN602 |
| A | HOH603 |
| A | HOH604 |
Catalytic Information from CSA
| site_id | MCSA1 |
| Number of Residues | 4 |
| Details | M-CSA 163 |
| Chain | Residue | Details |
| A | GLU478 | increase acidity, increase basicity, unknown |
| A | ASP498 | metal ligand |
| A | HIS539 | hydrogen bond acceptor, hydrogen bond donor, proton acceptor, proton donor, unknown |
| A | ASP549 | increase acidity, metal ligand, proton acceptor, proton donor |
