3HYF
Crystal structure of HIV-1 RNase H p15 with engineered E. coli loop and active site inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A (A) | Reverse transcriptase/RNaseH | polymer | 150 | 16921.5 | 1 | UniProt (Q72547) UniProt (P0A7Y4) Pfam (PF00075) | Human immunodeficiency virus 1 | |
| 2 | B, C (A) | MANGANESE (II) ION | non-polymer | 54.9 | 2 | Chemie (MN) | RNase HI, Ribonuclease H, RNase H | ||
| 3 | D (A) | ACETATE ION | non-polymer | 59.0 | 1 | Chemie (ACT) | |||
| 4 | E, F (A) | GLYCEROL | non-polymer | 92.1 | 2 | Chemie (GOL) | |||
| 5 | G (A) | 2-(3,4-dichlorobenzyl)-5,6-dihydroxypyrimidine-4-carboxylic acid | non-polymer | 315.1 | 1 | Chemie (ON1) | |||
| 6 | H (A) | water | water | 18.0 | 189 | Chemie (HOH) |
Sequence modifications
A: 427 - 506 (UniProt: Q72547)
A: 79 - 102 (UniProt: P0A7Y4)
A: 517 - 561 (UniProt: Q72547)
| PDB | External Database | Details |
|---|---|---|
| Met 426 | - | initiating methionine |
A: 517 - 561 (UniProt: Q72547)
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 16921.5 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 668.2 | |
| All* | Total formula weight | 17589.7 |
