6PAX
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![BU of 6pax by Molmil](/molmil-images/mine/6pax) | CRYSTAL STRUCTURE OF THE HUMAN PAX-6 PAIRED DOMAIN-DNA COMPLEX REVEALS A GENERAL MODEL FOR PAX PROTEIN-DNA INTERACTIONS | 分子名称: | 26 NUCLEOTIDE DNA, HOMEOBOX PROTEIN PAX-6 | 著者 | Xu, H.E, Rould, M.A, Xu, W, Epstein, J.A, Maas, R.L, Pabo, C.O. | 登録日 | 1999-04-22 | 公開日 | 1999-07-13 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of the human Pax6 paired domain-DNA complex reveals specific roles for the linker region and carboxy-terminal subdomain in DNA binding. Genes Dev., 13, 1999
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1KKQ
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![BU of 1kkq by Molmil](/molmil-images/mine/1kkq) | Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif | 分子名称: | N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL) PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE, NUCLEAR RECEPTOR CO-REPRESSOR 2, PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR | 著者 | Xu, H.E, Stanley, T.B, Montana, V.G, Lambert, M.H, Shearer, B.G, Cobb, J.E, McKee, D.D, Galardi, C.M, Nolte, R.T, Parks, D.J. | 登録日 | 2001-12-10 | 公開日 | 2002-02-20 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha. Nature, 415, 2002
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1GWX
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![BU of 1gwx by Molmil](/molmil-images/mine/1gwx) | MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS | 分子名称: | 2-(4-{3-[1-[2-(2-CHLORO-6-FLUORO-PHENYL)-ETHYL]-3-(2,3-DICHLORO-PHENYL)-UREIDO]-PROPYL}-PHENOXY)-2-METHYL-PROPIONIC ACID, PROTEIN (PPAR-DELTA) | 著者 | Xu, H.E, Lambert, M.H, Montana, V.G, Park, D.J, Blanchard, S, Brown, P, Sternbach, D, Lehmann, J, Bruce, G.W, Willson, T.M, Kliewer, S.A, Milburn, M.V. | 登録日 | 1999-03-17 | 公開日 | 2000-03-17 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol.Cell, 3, 1999
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8X8L
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![BU of 8x8l by Molmil](/molmil-images/mine/8x8l) | Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex | 分子名称: | Cortistatin, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Xu, H.E, You, C, Zhao, L, Li, J. | 登録日 | 2023-11-27 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.7 Å) | 主引用文献 | Cryo-EM structure of the cortistatin 17-bound Somatostatin receptor 5-Gi protein complex To Be Published
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8X8N
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![BU of 8x8n by Molmil](/molmil-images/mine/8x8n) | Cryo-EM structure of the octreotide-bound Somatostatin receptor 5-Gi protein complex | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(i) subunit alpha, ... | 著者 | Xu, H.E, You, C, Zhao, L, Li, J. | 登録日 | 2023-11-27 | 公開日 | 2024-06-12 | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | 主引用文献 | Cryo-EM structure of the octreotide-bound Somatostatin receptor 5-Gi protein complex To Be Published
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1K74
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![BU of 1k74 by Molmil](/molmil-images/mine/1k74) | The 2.3 Angstrom resolution crystal structure of the heterodimer of the human PPARgamma and RXRalpha ligand binding domains respectively bound with GW409544 and 9-cis retinoic acid and co-activator peptides. | 分子名称: | (9cis)-retinoic acid, 2-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID, Peroxisome proliferator activated receptor gamma, ... | 著者 | Xu, H.E, Lambert, M.H, Montana, V.G, Moore, L.B, Collins, J.L, Oplinger, J.A, Kliewer, S.A, Gampe Jr, R.T, McKee, D.D, Moore, J.T, Willson, T.M. | 登録日 | 2001-10-18 | 公開日 | 2001-12-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proc.Natl.Acad.Sci.USA, 98, 2001
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1K7L
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![BU of 1k7l by Molmil](/molmil-images/mine/1k7l) | The 2.5 Angstrom resolution crystal structure of the human PPARalpha ligand binding domain bound with GW409544 and a co-activator peptide. | 分子名称: | 2-(1-METHYL-3-OXO-3-PHENYL-PROPYLAMINO)-3-{4-[2-(5-METHYL-2-PHENYL-OXAZOL-4-YL)-ETHOXY]-PHENYL}-PROPIONIC ACID, Peroxisome proliferator activated receptor alpha, YTTRIUM (III) ION, ... | 著者 | Xu, H.E, Lambert, M.H, Montana, V.G, Moore, L.B, Collins, J.L, Oplinger, J.A, Kliewer, S.A, Gampe Jr, R.T, McKee, D.D, Moore, J.T, Willson, T.M. | 登録日 | 2001-10-19 | 公開日 | 2001-12-05 | 最終更新日 | 2024-02-07 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors. Proc.Natl.Acad.Sci.USA, 98, 2001
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3GWX
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![BU of 3gwx by Molmil](/molmil-images/mine/3gwx) | MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS | 分子名称: | 5,8,11,14,17-EICOSAPENTAENOIC ACID, PROTEIN (PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR (PPAR-DELTA)) | 著者 | Xu, H.E, Lambert, M.H, Montana, V.G, Parks, D.J, Blanchard, S.G, Brown, P.J, Sternbach, D.D, Lehmann, J.M, Wisely, G.B, Willson, T.M, Kliewer, S.A, Milburn, M.V. | 登録日 | 1999-04-26 | 公開日 | 2000-04-26 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol.Cell, 3, 1999
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2GWX
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![BU of 2gwx by Molmil](/molmil-images/mine/2gwx) | MOLECULAR RECOGNITION OF FATTY ACIDS BY PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS | 分子名称: | PROTEIN (PPAR-DELTA) | 著者 | Xu, H.E, Lambert, M.H, Montana, V.G, Park, D.J, Blanchard, S, Brown, P, Sternbach, D, Lehmann, J, Bruce, G.W, Willson, T.M, Kliewer, S.A, Milburn, M.V. | 登録日 | 1999-03-11 | 公開日 | 2000-03-11 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Molecular recognition of fatty acids by peroxisome proliferator-activated receptors. Mol.Cell, 3, 1999
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3BQD
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![BU of 3bqd by Molmil](/molmil-images/mine/3bqd) | Doubling the Size of the Glucocorticoid Receptor Ligand Binding Pocket by Deacylcortivazol | 分子名称: | 1-[(1R,2R,3aS,3bS,10aR,10bS,11S,12aS)-1,11-dihydroxy-2,5,10a,12a-tetramethyl-7-phenyl-1,2,3,3a,3b,7,10,10a,10b,11,12,12a-dodecahydrocyclopenta[5,6]naphtho[1,2-f]indazol-1-yl]-2-hydroxyethanone, Glucocorticoid receptor, Nuclear receptor coactivator 1 | 著者 | Xu, H.E. | 登録日 | 2007-12-20 | 公開日 | 2008-01-15 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Doubling the size of the glucocorticoid receptor ligand binding pocket by deacylcortivazol. Mol.Cell.Biol., 28, 2008
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3UC4
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![BU of 3uc4 by Molmil](/molmil-images/mine/3uc4) | The crystal structure of Snf1-related kinase 2.6 | 分子名称: | Serine/threonine-protein kinase SRK2E | 著者 | Zhou, X.E, Ng, L.-M, Soon, F.-F, Kovach, A, Suino-Powell, K.M, Li, J, Melcher, K, Xu, H.E. | 登録日 | 2011-10-26 | 公開日 | 2011-12-14 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Structural basis for basal activity and autoactivation of abscisic acid (ABA) signaling SnRK2 kinases. Proc.Natl.Acad.Sci.USA, 108, 2011
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5JA5
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![BU of 5ja5 by Molmil](/molmil-images/mine/5ja5) | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) L111A and L130A mutant in complex with rice D53 repressor EAR peptide motif | 分子名称: | Protein TPR1, The rice D53 peptide (a.a. 794-808), ZINC ION | 著者 | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | 登録日 | 2016-04-12 | 公開日 | 2017-07-05 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex. Sci Adv, 3, 2017
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5JHP
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![BU of 5jhp by Molmil](/molmil-images/mine/5jhp) | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) L179A and I195A mutant in complex with rice D53 repressor EAR peptide motif | 分子名称: | Protein TPR1, The rice D53 EAR peptide (794-808) | 著者 | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | 登録日 | 2016-04-21 | 公開日 | 2017-07-05 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | 主引用文献 | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex. Sci Adv, 3, 2017
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5J9K
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![BU of 5j9k by Molmil](/molmil-images/mine/5j9k) | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) in complex with rice D53 repressor EAR peptide motif | 分子名称: | Protein TPR1, ZINC ION, rice D53 peptide 794-808 | 著者 | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | 登録日 | 2016-04-10 | 公開日 | 2017-07-05 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.55 Å) | 主引用文献 | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex. Sci Adv, 3, 2017
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5JGC
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![BU of 5jgc by Molmil](/molmil-images/mine/5jgc) | Crystal structure of the rice Topless related protein 2 (TPR2) N-terminal topless domain (1-209) L111A, L130A, L179A and I195A mutant | 分子名称: | Protein TPR1, ZINC ION | 著者 | Ke, J, Ma, H, Gu, X, Brunzelle, J.S, Xu, H.E, Melcher, K. | 登録日 | 2016-04-20 | 公開日 | 2017-07-05 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | A D53 repression motif induces oligomerization of TOPLESS corepressors and promotes assembly of a corepressor-nucleosome complex. Sci Adv, 3, 2017
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3KB3
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![BU of 3kb3 by Molmil](/molmil-images/mine/3kb3) | Crystal structure of abscisic acid-bound PYL2 in complex with HAB1 | 分子名称: | (2Z,4E)-5-[(1S)-1-hydroxy-2,6,6-trimethyl-4-oxocyclohex-2-en-1-yl]-3-methylpenta-2,4-dienoic acid, MAGNESIUM ION, Protein phosphatase 2C 16, ... | 著者 | Zhou, X.E, Melcher, K, Soon, F.-F, Ng, L.-M, Xu, Y, Suino-Powell, K.M, Kovach, A, Li, J, Xu, H.E. | 登録日 | 2009-10-20 | 公開日 | 2009-12-08 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | Agate-latch-lock mechanism for hormone signalling by abscisic acid receptors Nature, 462, 2009
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5TO5
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![BU of 5to5 by Molmil](/molmil-images/mine/5to5) | Structure of the TPR oligomerization domain | 分子名称: | Nucleoprotein TPR | 著者 | Pal, K, Xu, Q, Zhou, X.E, Melcher, K, Xu, H.E. | 登録日 | 2016-10-16 | 公開日 | 2017-10-18 | 最終更新日 | 2024-03-06 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural Basis of TPR-Mediated Oligomerization and Activation of Oncogenic Fusion Kinases. Structure, 25, 2017
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4MY2
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![BU of 4my2 by Molmil](/molmil-images/mine/4my2) | Crystal Structure of Norrin in fusion with Maltose Binding Protein | 分子名称: | Maltose-binding periplasmic protein, Norrin fusion protein, alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose | 著者 | Ke, J, Jurecky, C, Chen, C, Gu, X, Parker, N, Williams, B.O, Melcher, K, Xu, H.E. | 登録日 | 2013-09-27 | 公開日 | 2013-11-13 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | 主引用文献 | Structure and function of Norrin in assembly and activation of a Frizzled 4-Lrp5/6 complex. Genes Dev., 27, 2013
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8W87
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![BU of 8w87 by Molmil](/molmil-images/mine/8w87) | Cryo-EM structure of the METH-TAAR1 complex | 分子名称: | (2S)-N-methyl-1-phenylpropan-2-amine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. | 登録日 | 2023-09-01 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
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8W8B
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![BU of 8w8b by Molmil](/molmil-images/mine/8w8b) | Cryo-EM structure of SEP-363856 bounded serotonin 1A (5-HT1A) receptor-Gi protein complex | 分子名称: | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, Antibody fragment scFv16, CHOLESTEROL, ... | 著者 | Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. | 登録日 | 2023-09-01 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (3 Å) | 主引用文献 | Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
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8W8A
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![BU of 8w8a by Molmil](/molmil-images/mine/8w8a) | Cryo-EM structure of the RO5256390-TAAR1 complex | 分子名称: | (4S)-4-[(2S)-2-phenylbutyl]-1,3-oxazolidin-2-imine, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, ... | 著者 | Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. | 登録日 | 2023-09-01 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | 主引用文献 | Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
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8W88
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![BU of 8w88 by Molmil](/molmil-images/mine/8w88) | Cryo-EM structure of the SEP363856-bound TAAR1-Gs complex | 分子名称: | 1-[(7~{S})-5,7-dihydro-4~{H}-thieno[2,3-c]pyran-7-yl]-~{N}-methyl-methanamine, CHOLESTEROL, Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, ... | 著者 | Liu, H, Zheng, Y, Wang, Y, Wang, Y, He, X, Xu, P, Huang, S, Yuan, Q, Zhang, X, Wang, S, Xu, H.E, Xu, F. | 登録日 | 2023-09-01 | 公開日 | 2023-11-22 | 最終更新日 | 2024-01-03 | 実験手法 | ELECTRON MICROSCOPY (2.6 Å) | 主引用文献 | Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature, 624, 2023
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4N2Q
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![BU of 4n2q by Molmil](/molmil-images/mine/4n2q) | Crystal structure of THA8 in complex with Zm4 RNA | 分子名称: | RNA (5'-R(*AP*AP*GP*AP*AP*GP*AP*AP*AP*UP*UP*GP*G)-3'), THA8 RNA binding protein | 著者 | Ke, J, Chen, R.Z, Ban, T, Zhou, X.E, Gu, X, Brunzelle, J.S, Zhu, J.K, Melcher, K, Xu, H.E. | 登録日 | 2013-10-06 | 公開日 | 2013-10-30 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Structural basis for RNA recognition by a dimeric PPR-protein complex. Nat.Struct.Mol.Biol., 20, 2013
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4N2S
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![BU of 4n2s by Molmil](/molmil-images/mine/4n2s) | Crystal Structure of THA8 in complex with Zm1a-6 RNA | 分子名称: | THA8 RNA binding protein, Zm1a-6 RNA | 著者 | Ke, J, Chen, R.Z, Ban, T, Zhou, X.E, Gu, X, Brunzelle, J.S, Zhu, J.K, Melcher, K, Xu, H.E. | 登録日 | 2013-10-06 | 公開日 | 2013-10-30 | 最終更新日 | 2024-04-03 | 実験手法 | X-RAY DIFFRACTION (3 Å) | 主引用文献 | Structural basis for RNA recognition by a dimeric PPR-protein complex. Nat.Struct.Mol.Biol., 20, 2013
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3L3Z
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![BU of 3l3z by Molmil](/molmil-images/mine/3l3z) | Crystal structure of DHT-bound androgen receptor in complex with the third motif of steroid receptor coactivator 3 | 分子名称: | 5-ALPHA-DIHYDROTESTOSTERONE, Androgen receptor, Nuclear receptor coactivator 3 | 著者 | Zhou, X.E, Suino-Powell, K.M, Li, J, He, A, MacKeigan, J.P, Melcher, K, Yong, E.-L, Xu, H.E. | 登録日 | 2009-12-18 | 公開日 | 2010-01-12 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Identification of SRC3/AIB1 as a Preferred Coactivator for Hormone-activated Androgen Receptor. J.Biol.Chem., 285, 2010
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