1KKQ

Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif

Summary for 1KKQ

Related1k7L 1k74
DescriptorPEROXISOME PROLIFERATOR ACTIVATED RECEPTOR, NUCLEAR RECEPTOR CO-REPRESSOR 2, N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL) PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE, ... (4 entities in total)
Functional Keywordsnuclear corepressor nuclear hormone receptors antagonist, transcription
Biological sourceHomo sapiens (human)
More
Cellular locationNucleus Q07869 Q9Y618
Total number of polymer chains8
Total molecular weight133211.69
Authors
Xu, H.E.,Stanley, T.B.,Montana, V.G.,Lambert, M.H.,Shearer, B.G.,Cobb, J.E.,McKee, D.D.,Galardi, C.M.,Nolte, R.T.,Parks, D.J. (deposition date: 2001-12-10, release date: 2002-02-20, Last modification date: 2017-10-11)
Primary citation
Xu, H.E.,Stanley, T.B.,Montana, V.G.,Lambert, M.H.,Shearer, B.G.,Cobb, J.E.,McKee, D.D.,Galardi, C.M.,Plunket, K.D.,Nolte, R.T.,Parks, D.J.,Moore, J.T.,Kliewer, S.A.,Willson, T.M.,Stimmel, J.B.
Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.
Nature, 415:813-817, 2002
PubMed: 11845213 (PDB entries with the same primary citation)
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (3 Å)
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Structure validation

ClashscoreRamachandran outliersSidechain outliers496.3%18.8%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution