1KKQ

Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B, C, D	PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR	polymer	269	30442.6	4	UniProt (Q07869) Pfam (PF00104) In PDB	Homo sapiens (human)	PPAR-alpha ligand-binding domain
2	E, F, G, H	NUCLEAR RECEPTOR CO-REPRESSOR 2	polymer	19	2240.7	4	UniProt (Q9Y618) In PDB		nuclear corepressor SMRT C-terminal receptor interacting motif
3	A, B, C, D	N-((2S)-2-({(1Z)-1-METHYL-3-OXO-3-[4-(TRIFLUOROMETHYL) PHENYL]PROP-1-ENYL}AMINO)-3-{4-[2-(5-METHYL-2-PHENYL-1,3-OXAZOL-4-YL)ETHOXY]PHENYL}PROPYL)PROPANAMIDE	non-polymer		619.7	4	Chemie (471)
4		water	water		18.0	330	Chemie (HOH)

Contents of the asymmetric unit

Polymers	Number of chains	8
	Total formula weight	130733.0
Non-Polymers*	Number of molecules	4
	Total formula weight	2478.7
All*	Total formula weight	133211.7

*Water molecules are not included.