1KKQ
Crystal structure of the human PPAR-alpha ligand-binding domain in complex with an antagonist GW6471 and a SMRT corepressor motif
Functional Information from GO Data
Chain | GOid | namespace | contents |
A | 0003677 | molecular_function | DNA binding |
A | 0004879 | molecular_function | nuclear receptor activity |
A | 0005634 | cellular_component | nucleus |
A | 0006355 | biological_process | regulation of DNA-templated transcription |
B | 0003677 | molecular_function | DNA binding |
B | 0004879 | molecular_function | nuclear receptor activity |
B | 0005634 | cellular_component | nucleus |
B | 0006355 | biological_process | regulation of DNA-templated transcription |
C | 0003677 | molecular_function | DNA binding |
C | 0004879 | molecular_function | nuclear receptor activity |
C | 0005634 | cellular_component | nucleus |
C | 0006355 | biological_process | regulation of DNA-templated transcription |
D | 0003677 | molecular_function | DNA binding |
D | 0004879 | molecular_function | nuclear receptor activity |
D | 0005634 | cellular_component | nucleus |
D | 0006355 | biological_process | regulation of DNA-templated transcription |
Functional Information from PDB Data
site_id | AC1 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 471 A 775 |
Chain | Residue |
A | LEU254 |
A | PHE351 |
A | ILE354 |
A | HIS440 |
A | VAL444 |
A | LEU456 |
A | HOH798 |
A | GLU269 |
A | ILE272 |
A | PHE273 |
A | CYS275 |
A | CYS276 |
A | SER280 |
A | TYR314 |
A | VAL332 |
site_id | AC2 |
Number of Residues | 14 |
Details | BINDING SITE FOR RESIDUE 471 B 776 |
Chain | Residue |
B | LEU254 |
B | ILE272 |
B | CYS276 |
B | THR279 |
B | SER280 |
B | TYR314 |
B | MET330 |
B | VAL332 |
B | LEU344 |
B | PHE351 |
B | ILE354 |
B | MET355 |
B | HIS440 |
B | HOH794 |
site_id | AC3 |
Number of Residues | 15 |
Details | BINDING SITE FOR RESIDUE 471 C 777 |
Chain | Residue |
C | ILE241 |
C | ILE272 |
C | PHE273 |
C | CYS275 |
C | CYS276 |
C | GLN277 |
C | THR279 |
C | SER280 |
C | TYR314 |
C | MET330 |
C | VAL332 |
C | PHE351 |
C | ILE354 |
C | HIS440 |
C | HOH816 |
site_id | AC4 |
Number of Residues | 13 |
Details | BINDING SITE FOR RESIDUE 471 D 778 |
Chain | Residue |
D | LEU254 |
D | GLU269 |
D | ILE272 |
D | PHE273 |
D | CYS276 |
D | GLN277 |
D | SER280 |
D | TYR314 |
D | MET330 |
D | VAL332 |
D | LEU344 |
D | PHE351 |
D | HOH779 |
Functional Information from SwissProt/UniProt
site_id | SWS_FT_FI1 |
Number of Residues | 12 |
Details | BINDING: BINDING => ECO:0000269|PubMed:19116277, ECO:0007744|PDB:3ET1 |
Chain | Residue | Details |
A | SER280 | |
A | TYR314 | |
A | TYR464 | |
B | SER280 | |
B | TYR314 | |
B | TYR464 | |
C | SER280 | |
C | TYR314 | |
C | TYR464 | |
D | SER280 | |
D | TYR314 | |
D | TYR464 |
site_id | SWS_FT_FI2 |
Number of Residues | 4 |
Details | SITE: Essential for heterodimerization with RXRA |
Chain | Residue | Details |
A | LEU433 | |
B | LEU433 | |
C | LEU433 | |
D | LEU433 |