3ET1

Structure of PPARalpha with 3-[5-Methoxy-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yl]-propionic acid

Summary for 3ET1

• Entry DOI: 10.2210/pdb3et1/pdb
• Related: 3ET0 3ET2 3ET3
• Descriptor: Peroxisome proliferator-activated receptor alpha, Steroid receptor coactivator 1, 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid, ... (4 entities in total)
• Functional Keywords: ppar, ppara, pparalpha, drug discovery, diabetes, adiponectin, metabolic disease, fragment-based drug discovery, scaffold-based drug discovery, activator, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, acyltransferase, alternative splicing, chromosomal rearrangement, phosphoprotein, proto-oncogene, transferase, ubl conjugation, transcription-transferase complex, transcription/transferase
• Biological source: Homo sapiens (human); More
• Cellular location: Nucleus: Q07869; Nucleus (By similarity): Q15788
• Total number of polymer chains: 4
• Total formula weight: 70457.90

Authors

Zhang, K.Y.J.,Wang, W. (deposition date: 2008-10-06, release date: 2009-02-17, Last modification date: 2023-09-06)

• Primary citation: Artis, D.R.,Lin, J.J.,Zhang, C.,Wang, W.,Mehra, U.,Perreault, M.,Erbe, D.,Krupka, H.I.,England, B.P.,Arnold, J.,Plotnikov, A.N.,Marimuthu, A.,Nguyen, H.,Will, S.,Signaevsky, M.,Kral, J.,Cantwell, J.,Settachatgull, C.,Yan, D.S.,Fong, D.,Oh, A.,Shi, S.,Womack, P.,Powell, B.,Habets, G.,West, B.L.,Zhang, K.Y.,Milburn, M.V.,Vlasuk, G.P.,Hirth, K.P.,Nolop, K.,Bollag, G.,Ibrahim, P.N.,Tobin, J.F.; Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent; Proc.Natl.Acad.Sci.USA, 106:262-267, 2009; PubMed: 19116277; DOI: 10.1073/pnas.0811325106

Experimental method

X-RAY DIFFRACTION (2.5 Å)