3ET1

Structure of PPARalpha with 3-[5-Methoxy-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yl]-propionic acid

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A, B (A, B)	Peroxisome proliferator-activated receptor alpha	polymer	291	32874.2	2	UniProt (Q07869) Pfam (PF00104)	Homo sapiens (human)	PPAR-alpha, Nuclear receptor subfamily 1 group C member 1
2	C, D (P, Q)	Steroid receptor coactivator 1	polymer	16	1965.3	2	UniProt (Q15788)	Homo sapiens (human)	NCoA-1, Nuclear receptor coactivator 1, SRC-1, RIP160, Protein Hin-2, Renal carcinoma antigen NY-REN-52
3	E, F (A, B)	3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid	non-polymer		389.4	2	Chemie (ET1)
4	G, H, I, J (A, B, P, Q)	water	water		18.0	93	Chemie (HOH)

Sequence modifications

A, B: 199 - 468 (UniProt: Q07869)

PDB	External Database	Details
Met 178	-	expression tag
Gly 179	-	expression tag
Ser 180	-	expression tag
Ser 181	-	expression tag
His 182	-	expression tag
His 183	-	expression tag
His 184	-	expression tag
His 185	-	expression tag
His 186	-	expression tag
His 187	-	expression tag
Ser 188	-	expression tag
Ser 189	-	expression tag
Gly 190	-	expression tag
Leu 191	-	expression tag
Val 192	-	expression tag
Pro 193	-	expression tag
Arg 194	-	expression tag
Gly 195	-	expression tag
Ser 196	-	expression tag
His 197	-	expression tag
Met 198	-	expression tag

Contents of the asymmetric unit

Polymers	Number of chains	4
	Total formula weight	69679.1
Non-Polymers*	Number of molecules	2
	Total formula weight	778.8
All*	Total formula weight	70457.9

*Water molecules are not included.