3ET1
Structure of PPARalpha with 3-[5-Methoxy-1-(4-methoxy-benzenesulfonyl)-1H-indol-3-yl]-propionic acid
Summary for 3ET1
Entry DOI | 10.2210/pdb3et1/pdb |
Related | 3ET0 3ET2 3ET3 |
Descriptor | Peroxisome proliferator-activated receptor alpha, Steroid receptor coactivator 1, 3-{5-methoxy-1-[(4-methoxyphenyl)sulfonyl]-1H-indol-3-yl}propanoic acid, ... (4 entities in total) |
Functional Keywords | ppar, ppara, pparalpha, drug discovery, diabetes, adiponectin, metabolic disease, fragment-based drug discovery, scaffold-based drug discovery, activator, dna-binding, metal-binding, nucleus, polymorphism, receptor, transcription, transcription regulation, zinc, zinc-finger, acyltransferase, alternative splicing, chromosomal rearrangement, phosphoprotein, proto-oncogene, transferase, ubl conjugation, transcription-transferase complex, transcription/transferase |
Biological source | Homo sapiens (human) More |
Cellular location | Nucleus: Q07869 Nucleus (By similarity): Q15788 |
Total number of polymer chains | 4 |
Total formula weight | 70457.90 |
Authors | Zhang, K.Y.J.,Wang, W. (deposition date: 2008-10-06, release date: 2009-02-17, Last modification date: 2023-09-06) |
Primary citation | Artis, D.R.,Lin, J.J.,Zhang, C.,Wang, W.,Mehra, U.,Perreault, M.,Erbe, D.,Krupka, H.I.,England, B.P.,Arnold, J.,Plotnikov, A.N.,Marimuthu, A.,Nguyen, H.,Will, S.,Signaevsky, M.,Kral, J.,Cantwell, J.,Settachatgull, C.,Yan, D.S.,Fong, D.,Oh, A.,Shi, S.,Womack, P.,Powell, B.,Habets, G.,West, B.L.,Zhang, K.Y.,Milburn, M.V.,Vlasuk, G.P.,Hirth, K.P.,Nolop, K.,Bollag, G.,Ibrahim, P.N.,Tobin, J.F. Scaffold-based discovery of indeglitazar, a PPAR pan-active anti-diabetic agent Proc.Natl.Acad.Sci.USA, 106:262-267, 2009 Cited by PubMed: 19116277DOI: 10.1073/pnas.0811325106 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.5 Å) |
Structure validation
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