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3CDU
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BU of 3cdu by Molmil
Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with a pyrophosphate
分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
著者Gruez, A, Selisko, B, Roberts, M, Bricogne, G, Bussetta, C, Canard, B.
登録日2008-02-27
公開日2008-07-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases
J.Virol., 82, 2008
3CDW
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BU of 3cdw by Molmil
Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with protein primer VPg and a pyrophosphate
分子名称: ACETATE ION, CHLORIDE ION, GLYCEROL, ...
著者Gruez, A, Selisko, B, Roberts, M, Bricogne, G, Bussetta, C, Canard, B.
登録日2008-02-27
公開日2008-07-22
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases
J.Virol., 82, 2008
7ED5
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BU of 7ed5 by Molmil
A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase
分子名称: MAGNESIUM ION, Non-structural protein 7, Non-structural protein 8, ...
著者Shannon, A, Fattorini, V, Sama, B, Selisko, B, Feracci, M, Falcou, C, Gauffre, P, El Kazzi, P, Delpal, A, Decroly, E, Alvarez, K, Eydoux, C, Guillemot, J.-C, Moussa, A, Good, S, Colla, P, Lin, K, Sommadossi, J.-P, Zhu, Y.X, Yan, X.D, Shi, H, Ferron, F, Canard, B.
登録日2021-03-15
公開日2022-02-16
最終更新日2024-04-10
実験手法ELECTRON MICROSCOPY (2.98 Å)
主引用文献A dual mechanism of action of AT-527 against SARS-CoV-2 polymerase.
Nat Commun, 13, 2022
1L9K
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BU of 1l9k by Molmil
dengue methyltransferase
分子名称: RNA-DIRECTED RNA POLYMERASE, S-ADENOSYL-L-HOMOCYSTEINE, SULFATE ION
著者Egloff, M.P, Benarroch, D, Selisko, B, Romette, J.L, Canard, B.
登録日2002-03-25
公開日2003-03-25
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献An RNA cap (nucleoside-2'-O-) methyltransferase in the flavivirus RNA polymerase NS5: crystal structure and functional characterization
Embo J., 21, 2002
2QEQ
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BU of 2qeq by Molmil
Crystal structure of kunjin virus ns3 helicase
分子名称: Flavivirin protease NS3 catalytic subunit
著者Milani, M, Mastrangelo, E, Bolognesi, M.
登録日2007-06-26
公開日2007-08-14
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献Crystal structure and activity of Kunjin virus NS3 helicase; protease and helicase domain assembly in the full length NS3 protein
J.Mol.Biol., 372, 2007
4Y2A
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BU of 4y2a by Molmil
Crystal Structure of Coxsackie Virus B3 3D polymerase in complex with GPC-N114 inhibitor
分子名称: 2,2'-[(4-chlorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ...
著者Vives-Adrian, L, Ferrer-Orta, C, Verdaguer, N.
登録日2015-02-09
公開日2015-04-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
4Y34
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BU of 4y34 by Molmil
Crystal Structure of Coxsackievirus B3 3D polymerase in complex with GPC-N143
分子名称: 2,2'-[(4-fluorobenzene-1,2-diyl)bis(oxy)]bis(5-nitrobenzonitrile), 3D polymerase, GLYCEROL, ...
著者Vives-Adrian, L, Ferrer-Orta, C, Cerdaguer, N.
登録日2015-02-10
公開日2015-04-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
4Y3C
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BU of 4y3c by Molmil
I304V 3D polymerase mutant of EMCV
分子名称: 3D polymerase, CHLORIDE ION, GLYCEROL
著者Verdaguer, N, Ferrer-Orta, C, Vives-Adrian, L.
登録日2015-02-10
公開日2015-04-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
5M5B
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BU of 5m5b by Molmil
Crystal structure of Zika virus NS5 methyltransferase
分子名称: CHLORIDE ION, GLYCEROL, NS5 methyltransferase, ...
著者Barral, K, Ortiz Lombardia, M, Coutard, B, Decroly, E, Lichiere, J.
登録日2016-10-21
公開日2016-12-28
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Zika Virus Methyltransferase: Structure and Functions for Drug Design Perspectives.
J. Virol., 91, 2017
4Y2C
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BU of 4y2c by Molmil
M300V 3D polymerase mutant of EMCV
分子名称: GLYCEROL, Genome polyprotein
著者Verdaguer, N, Ferrer-Orta, C, Vives-Adrian, L.
登録日2015-02-09
公開日2015-04-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献The RNA Template Channel of the RNA-Dependent RNA Polymerase as a Target for Development of Antiviral Therapy of Multiple Genera within a Virus Family.
Plos Pathog., 11, 2015
8BCR
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BU of 8bcr by Molmil
DENV3 Methyltransferase in complexed with AT-9010 and SAH
分子名称: Genome polyprotein, PHOSPHATE ION, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Gauffre, P, Fattorini, V, Canard, B, Ferron, F.
登録日2022-10-17
公開日2023-03-22
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献AT-752 targets multiple sites and activities on the Dengue virus replication enzyme NS5.
Antiviral Res., 212, 2023
8PYW
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BU of 8pyw by Molmil
Crystal structure of the human Nucleoside-diphosphate kinase B domain bound to compound diphosphate form of AT-9052-Sp.
分子名称: GLYCEROL, Nucleoside diphosphate kinase B, [[(2R,3R,4R,5R)-5-(2-azanyl-6-oxidanylidene-1H-purin-9-yl)-4-fluoranyl-4-methyl-3-oxidanyl-oxolan-2-yl]methoxy-sulfanyl-phosphoryl] dihydrogen phosphate
著者Feracci, M, Chazot, A.
登録日2023-07-26
公開日2023-12-27
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.553 Å)
主引用文献An exonuclease-resistant chain-terminating nucleotide analogue targeting the SARS-CoV-2 replicase complex.
Nucleic Acids Res., 52, 2024
4NYZ
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BU of 4nyz by Molmil
The EMCV 3Dpol structure with altered motif A conformation at 2.15A resolution
分子名称: GLUTAMINE, GLYCEROL, Genome polyprotein, ...
著者Vives-adrian, L, Lujan, C, Ferrer-orta, C, Verdaguer, N.
登録日2013-12-11
公開日2014-03-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site
J.Virol., 88, 2014
4NZ0
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BU of 4nz0 by Molmil
The EMCV 3Dpol structure at 2.8A resolution
分子名称: CHLORIDE ION, GLYCEROL, Genome polyprotein
著者Vives-adrian, L, Ferrer-orta, C, Verdaguer, N.
登録日2013-12-11
公開日2014-03-19
最終更新日2023-11-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献The crystal structure of a cardiovirus RNA-dependent RNA polymerase reveals an unusual conformation of the polymerase active site
J.Virol., 88, 2014
6SX8
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BU of 6sx8 by Molmil
Mopeia Virus Exonuclease domain complexed with Manganese
分子名称: MANGANESE (II) ION, Nucleoprotein, ZINC ION
著者Nguyen, T.H.V, Ferron, F.
登録日2019-09-25
公開日2021-07-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate
Iucrj, 2022
6SY8
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BU of 6sy8 by Molmil
Mopeia Virus Exonuclease domain fully depleted of Manganese un ALD compound
分子名称: Nucleoprotein, ZINC ION
著者Nguyen, T.H.V, Ferron, F.
登録日2019-09-27
公開日2021-07-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2.08 Å)
主引用文献Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate
Iucrj, 2022
6T2A
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BU of 6t2a by Molmil
Mopeia Virus Exonuclease domain partially complexed with Manganese
分子名称: DI(HYDROXYETHYL)ETHER, MANGANESE (II) ION, Nucleoprotein, ...
著者Nguyen, T.H.V, Ferron, F.
登録日2019-10-08
公開日2021-04-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate
Iucrj, 2022
6T6L
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BU of 6t6l by Molmil
Mopeia Virus Exonuclease domain complexed soak with Alendronate
分子名称: MANGANESE (II) ION, Nucleoprotein, ZINC ION
著者Nguyen, T.H.V, Ferron, F.
登録日2019-10-18
公開日2021-07-14
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.757 Å)
主引用文献Inhibition of Arenaviridae nucleoprotein exonuclease by bisphosphonate
Iucrj, 2022
3ELD
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BU of 3eld by Molmil
Wesselsbron methyltransferase in complex with Sinefungin
分子名称: Methyltransferase, SINEFUNGIN, SULFATE ION
著者Bollati, M, Milani, M, Mastrangelo, E, Ricagno, S, Bolognesi, M.
登録日2008-09-22
公開日2008-11-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELU
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BU of 3elu by Molmil
Wesselsbron virus Methyltransferase in complex with AdoMet
分子名称: Methyltransferase, S-ADENOSYLMETHIONINE, SULFATE ION
著者Bollati, M, Ricagno, S, Milani, M, Mastrangelo, E, Bolognesi, M.
登録日2008-09-23
公開日2008-11-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3EMD
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BU of 3emd by Molmil
Wesselsbron virus Methyltransferase in complex with Sinefungin and 7MeGpppA
分子名称: P1-7-METHYLGUANOSINE-P3-ADENOSINE-5',5'-TRIPHOSPHATE, SINEFUNGIN, SULFATE ION, ...
著者Bollati, M, Milani, M, Ricagno, S, Mastrangelo, E, Bolognesi, M.
登録日2008-09-24
公開日2008-11-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELY
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BU of 3ely by Molmil
Wesselsbron virus Methyltransferase in complex with AdoHcy
分子名称: DI(HYDROXYETHYL)ETHER, Methyltransferase, S-ADENOSYL-L-HOMOCYSTEINE, ...
著者Bollati, M, Milani, M, Ricagno, S, Mastrangelo, E, Bolognesi, M.
登録日2008-09-23
公開日2008-11-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3EMB
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BU of 3emb by Molmil
Wesselsbron virus Methyltransferase in complex with AdoMet and 7MeGpppG
分子名称: 7-METHYL-GUANOSINE-5'-TRIPHOSPHATE-5'-GUANOSINE, Methyltransferase, S-ADENOSYLMETHIONINE, ...
著者Bollati, M, Ricagno, S, Milani, M, Mastrangelo, E, Bolognesi, M.
登録日2008-09-24
公開日2008-11-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
3ELW
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BU of 3elw by Molmil
Wesselsbron virus Methyltransferase in complex with AdoMet and GpppG
分子名称: DIGUANOSINE-5'-TRIPHOSPHATE, Methyltransferase, S-ADENOSYLMETHIONINE, ...
著者Bollati, M, Ricagno, S, Milani, M, Mastrangelo, E, Bolognesi, M.
登録日2008-09-23
公開日2008-11-18
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Recognition of RNA Cap in the Wesselsbron Virus NS5 Methyltransferase Domain: Implications for RNA-Capping Mechanisms in Flavivirus
J.Mol.Biol., 385, 2009
2HCN
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BU of 2hcn by Molmil
Crystal structure of RNA dependent RNA polymerase domain from west nile virus
分子名称: CALCIUM ION, RNA-directed RNA polymerase (NS5), ZINC ION
著者Egloff, M.P, Malet, H, Marseilles Structural Genomics Program @ AFMB (MSGP)
登録日2006-06-17
公開日2007-02-06
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (2.35 Å)
主引用文献Crystal structure of the RNA polymerase domain of the West Nile virus non-structural protein 5
J.Biol.Chem., 282, 2007

 

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