3CDW

Crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase (3Dpol) in complex with protein primer VPg and a pyrophosphate

Summary for 3CDW

Related3CDU 2ILZ 2F8E 2E9Z 1XR5
DescriptorRNA-directed RNA polymerase 3D-POL, Protein 3B, CHLORIDE ION, ... (7 entities in total)
Functional Keywordscoxsackievirus, rna-dependent rna polymerase, protein primer, vpg, vizier viral enzymes involved in replication, transferase-viral protein complex, transferase/viral protein
Biological sourceCoxsackievirus B3
More
Cellular locationProtein VP2: Virion. Protein VP3: Virion. Protein VP1: Virion. Protein 2B: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 2C: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3A: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential). Protein 3B: Virion (Potential). Picornain 3C: Host cytoplasm (Potential). RNA-directed RNA polymerase 3D-POL: Host cytoplasmic vesicle membrane; Peripheral membrane protein; Cytoplasmic side (Potential) P03313 P03313
Total number of polymer chains2
Total molecular weight58955.59
Authors
Gruez, A.,Selisko, B.,Roberts, M.,Bricogne, G.,Bussetta, C.,Canard, B. (deposition date: 2008-02-27, release date: 2008-07-22, Last modification date: 2011-07-13)
Primary citation
Gruez, A.,Selisko, B.,Roberts, M.,Bricogne, G.,Bussetta, C.,Jabafi, I.,Coutard, B.,De Palma, A.M.,Neyts, J.,Canard, B.
The crystal structure of coxsackievirus B3 RNA-dependent RNA polymerase in complex with its protein primer VPg confirms the existence of a second VPg binding site on Picornaviridae polymerases
J.Virol., 82:9577-9590, 2008
PubMed: 18632861 (PDB entries with the same primary citation)
DOI: 10.1128/JVI.00631-08
MImport into Mendeley
Experimental method
X-RAY DIFFRACTION (2.5 Å)
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Structure validation

RfreeClashscoreRamachandran outliersSidechain outliersRSRZ outliers0.2192304.8%2.3%MetricValuePercentile RanksWorseBetterPercentile relative to all X-ray structuresPercentile relative to X-ray structures of similar resolution